T
tareload
Guest
Source for this table?
Please see below:
Testosterone preparations for clinical use in males (Chapter 15) - Testosterone
Testosterone - July 2012
www.cambridge.org
Abstract: Testosterone undecanoate (TU) dissolved in soybean oil was developed in China to improve the pharmacokinetics of this testosterone ester in comparison with TU in castor or tea seed oil. As a pre-clinical primate model, three groups of five castrated cynomolgus macaques received either a single intramuscular injection of 10 mg/kg bodyweight TU in soybean oil, in tea seed oil, or in castor oil (equals 6.3 mg pure T/kg bodyweight for all preparations). Testosterone, estradiol, luteinizing hormone, and follicle-stimulating hormone as well as prostate volume, body weight and ejaculate weight were evaluated. After injection supraphysiological testosterone levels were induced. There were no significant differences in the pharmacokinetics of the three TU preparations for testosterone and estradiol. The gonadotropin levels showed a high individual variation. Prostate volumes increased equally in all groups after administration and declined to castrate level afterwards. The results suggest that TU in soybean oil produces similar effects as TU in the other vehicles. This study in non-human primates provides no objection to testing of this new preparation in humans.
Intramuscular injection of testosterone undecanoate for the treatment of male hypogonadism: phase I studies
OBJECTIVE: In the search for long-acting testosterone preparations suited for substitution therapy of hypogonadal men, testosterone undecanoate (TU) dissolved in either tea seed oil or castor oil was investigated. DESIGN: In study I, 1000 mg TU in tea seed oil (125 mg/ml) were injected in equal...
@Gladiator @Mastodont I hope the resources above are helpful to the discussion.
Last edited by a moderator:
