Surprising Blood Work - Attempting to restore non existent libido

The slice

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I have battled with libido for years and it has been suggested that my E2 is too low and I am probably running my test too high. Despite only running 140mg my Free test was sky high, very high androgen index and low SHBG.

So in order to attempt a more favorable test/androgen to E2 Ratio I lowered my test from 140MG to 87.5 and added HCG at 500iu EOD.

My Blood work is surpising - My Test is higher, My E2 is higher, my free T is way higher, my SHBG is lower and my free andogens have literally doubled.

My libido has not made any improvement - I am way more short tempered and its now way harder to ejaculate.

Really no idea how to move forward


Blood work @140MG test / Week.

SHBG - 15 (18.3 - 54.1) nmol/L

OESTRADIOL 62 (41 - 159 R) pmol/L

TESTOSTERONE 23.3 (8.64 - 29 R) nmol/L

FREE TESTOSTERONE -0.69 (0.2 - 0.62 R) nmol/L

FREE ANDROGEN INDEX 150.3 (24 - 104 R)

PROLACTIN 253 (86 - 324) mU/L


Blood work at 87mg test and 500iu HCG EOD

It’s been a month since I implemented the changes.

SHBG - 8 (18.3 - 54.1) nmol/L

OESTRADIOL 164 (41 - 159 R) pmol/L

TESTOSTERONE 28.8 (8.64 - 29 R) nmol/L

FREE TESTOSTERONE -1.04 (0.2 - 0.62 R) nmol/L

FREE ANDROGEN INDEX 325 (24 - 104 R)

PROLACTIN 257 (86 - 324) mU/L
 
You are taking a hefty dose of hCG and it seems like you are responding strongly to it with high endogenous production of T and E2. Try taking less of something. If the goal is to keep E2 as high as possible relative to T, then the something you take less of should probably be testosterone.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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