Should I up the cypionate dose?

Whatzup

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I've been on cypionate for 7 years or so using 50 to 200 weekly. I feel like no matter the dose I feel about the same. Sure hematocrit and rbc have been elevated the higher the dose but I felt the same. Anyhow, in order to lower hematocrit I finally started 50 again for the last 7 months and the hematocrit was 47 and other times 51.
Lately on 50 weekly I notice I am ok the first few days after the shot but later I feel tired and moody. My T has been like 580 like 38 hours later. I suspect much lower after that.
Should I up the dose?
 
I've been on cypionate for 7 years or so using 50 to 200 weekly. I feel like no matter the dose I feel about the same. Sure hematocrit and rbc have been elevated the higher the dose but I felt the same. Anyhow, in order to lower hematocrit I finally started 50 again for the last 7 months and the hematocrit was 47 and other times 51.
Lately on 50 weekly I notice I am ok the first few days after the shot but later I feel tired and moody. My T has been like 580 like 38 hours later. I suspect much lower after that.
Should I up the dose?

Why not try splitting the dose, say into 25-30 mg twice weekly? This will dampen the high/low swings if you're currently injecting once a week.
If I split the 50 twice a week what would my average daily T be having so little at a time? With 50 once a week it was around 580 in 36ish hours.
 
If I split the 50 twice a week what would my average daily T be having so little at a time? With 50 once a week it was around 580 in 36ish hours.

Splitting the dose does not affect your average level of testosterone. Currently you presumably have a relatively high level of testosterone in the day or two after each injection, but a low level in the day or two before each injection. For example, you might hit a peak of 750 ng/dL which drops to a trough of 250 ng/dL before the next injection. Your average could be about 500 ng/dL. If you switched to twice-weekly injections at the same mg/week then you might see a peak of 600 ng/dL dropping to 400 ng/dL while the average remains 500 ng/dL. Avoiding prolonged higher peaks may help to lower hematocrit.

When you say multiple injections per week are fatiguing, do you mean that it wears on you to inject more often or that you actually feel less energetic on the protocol? If it's the latter then we might hypothesize that you need higher peaks but lower average testosterone. You could achieve this by injecting daily with a propionate/cypionate blend. Alternatively you could switch to oral testosterone or testosterone nasal gel. These latter two approaches deliver relatively high, but short pulses of testosterone, which in turn yield lower trough and average testosterone levels. The success of these methods supports the hypothesis that peak daily levels are significant drivers of the benefits we receive from testosterone.
 
Splitting the dose does not affect your average level of testosterone. Currently you presumably have a relatively high level of testosterone in the day or two after each injection, but a low level in the day or two before each injection. For example, you might hit a peak of 750 ng/dL which drops to a trough of 250 ng/dL before the next injection. Your average could be about 500 ng/dL. If you switched to twice-weekly injections at the same mg/week then you might see a peak of 600 ng/dL dropping to 400 ng/dL while the average remains 500 ng/dL. Avoiding prolonged higher peaks may help to lower hematocrit.

When you say multiple injections per week are fatiguing, do you mean that it wears on you to inject more often or that you actually feel less energetic on the protocol? If it's the latter then we might hypothesize that you need higher peaks but lower average testosterone. You could achieve this by injecting daily with a propionate/cypionate blend. Alternatively you could switch to oral testosterone or testosterone nasal gel. These latter two approaches deliver relatively high, but short pulses of testosterone, which in turn yield lower trough and average testosterone levels. The success of these methods supports the hypothesis that peak daily levels are significant drivers of the benefits we receive from testosterone.
By fatigue I mean injecting so much gets old. Today I see the doctor. I will talk about all this.
I heard oral form is harsh on the liver. Is this correct?
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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