Lower T Dose

TDM812

Member
As evidenced by my posts over the past several months - I simply can’t get my e2 dialed in. I’ve tried nearly everything; split dose, sub q, compounded Anastrozole, etc. I’m currently at 140mg Cypionate split between 2 doses, and this puts me in the 1200-1500 total / 3.4 - 3.0 free range. My numbers are a little high, but so is my SHBG. As a last resort, I have lowered my dose to .25ml every 72 hours. This puts me at ~ 115mg weekly. At first blush it doesn’t look like a significant adjustment, but it’s about 8%. To my questions: how long will I feel crummy, how long to stabilize, should I still split dose or just do 120 weekly, do you think the sides will go away at the new dose, and most importantly - I have a job interview next Friday, how will the dose mod effect my performance?
 
As evidenced by my posts over the past several months - I simply can’t get my e2 dialed in. I’ve tried nearly everything; split dose, sub q, compounded Anastrozole, etc. I’m currently at 140mg Cypionate split between 2 doses, and this puts me in the 1200-1500 total / 3.4 - 3.0 free range. My numbers are a little high, but so is my SHBG. As a last resort, I have lowered my dose to .25ml every 72 hours. This puts me at ~ 115mg weekly. At first blush it doesn’t look like a significant adjustment, but it’s about 8%. To my questions: how long will I feel crummy, how long to stabilize, should I still split dose or just do 120 weekly, do you think the sides will go away at the new dose, and most importantly - I have a job interview next Friday, how will the dose mod effect my performance?
It takes my body about a week to adjust to changes I make but I have low shbg so I tend to clear more quickly.
 
As evidenced by my posts over the past several months - I simply can’t get my e2 dialed in. I’ve tried nearly everything; split dose, sub q, compounded Anastrozole, etc. I’m currently at 140mg Cypionate split between 2 doses, and this puts me in the 1200-1500 total / 3.4 - 3.0 free range. My numbers are a little high, but so is my SHBG. As a last resort, I have lowered my dose to .25ml every 72 hours. This puts me at ~ 115mg weekly. At first blush it doesn’t look like a significant adjustment, but it’s about 8%. To my questions: how long will I feel crummy, how long to stabilize, should I still split dose or just do 120 weekly, do you think the sides will go away at the new dose, and most importantly - I have a job interview next Friday, how will the dose mod effect my performance?
How's that new dosing treating you?
 
How's that new dosing treating you?
Thank you for asking. I noticed a difference, but I’m still all over the board. I took 60mg on 4/28, and started the new protocol (.25ml x 3 on 4/1, so it’s really only been 10 days. On 4/8 I felt like I was high and took .1 Arimidex. The next day I felt pretty crappy, but it had subsided by the next morning. This morning I was really tired, weak, no appetite, headache, and had trouble getting out of bed. I am not sure if it’s my body getting adjusted to the lower dose, high e, or low e. I’m thinking my E is high, but I don’t want to guess. Thoughts?
 
sounds like we're living through similar struggles I'm all over the place it just depends on the day of the week even if I don't change anything. While taking doses as high as 50 mg every other day and had my estradiol at 29 and felt like crap and I work the low side as well with low doses like 20 milligrams every other day. I try not to use an AI with it about once a week it seems like I have to and that creates a whole new different set of issues. Right now I'm exploring dropping to 8 mg everyday but Imma ride out what I'm on now for another week before I decide .
 
that post was a little hard to read through, don't have any input on the protocol but i would suggest listing out your lab work with numbers, units and ranges clearly. Also include your SHBG number specifically, and your E2. That will increase the probability of you getting some useful feedback.
 
Notice an absence of labs, any meaningful numbers and trying to go at it by feel of one day to the next and the associated frustration that comes from trying to do it this way.
 
Notice an absence of labs, any meaningful numbers and trying to go at it by feel of one day to the next and the associated frustration that comes from trying to do it this way.
I wasn't posting for feedback, I was posting to help the under other person understand that they're not the only one in that situation.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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