madman
Super Moderator
Shalin Shah is the CEO of Marius Pharmaceuticals and widely known as The Metabolic CEO. He’s a leading voice in metabolic health and hormone therapy innovation, and one of the strongest advocates working to destigmatize testosterone for both men and women.
In this episode, we go deep into what’s really happening with testosterone today — why levels are declining across the population, why this is not just a “male” issue, and why testosterone is foundational to metabolic health, longevity, mental health, bone density, and quality of life. Shalin breaks down complex science in a way that’s practical and empowering, and explains why testosterone deficiency is being massively underdiagnosed and undertreated.
We talk about environmental toxins, sleep disruption, stress, lifestyle, and the long-term consequences of ignoring low testosterone — including cardiovascular disease, diabetes, depression, frailty, and increased all-cause mortality. We also explore the future of hormone therapy, why testing should be standard, and how innovation like oral testosterone could change access and outcomes for millions of people.
This conversation is informative, eye-opening, and honestly a bit of a wake-up call — especially for anyone in midlife who wants to age strong, think clearly, and feel energized again.
What we cover:
- Why testosterone levels are declining in men and women
- Testosterone as a metabolic health marker, not a lifestyle drug
- The role of sleep, stress, toxins, and modern life
- Why fatigue, brain fog, depression, and low motivation are often hormonal
- The truth about testosterone myths and stigma
- Why testing matters — and why baselines should start early
- The difference between “normal” and “optimal” hormone levels
- Oral vs topical vs injectable testosterone
- Why muscle, bone health, and longevity are directly tied to hormones
- What’s changing at the FDA — and why this moment matters
