SHGB and Estrogen levels

duramax

Member
I’ve read many posts about how your Estrogen levels should mirror your shgb levels. What is a guy to do if his shgb levels are low? My shgb is at 12.....so what should I be seeking for E2 levels? Thanks
 
I’ve read many posts about how your Estrogen levels should mirror your shgb levels. What is a guy to do if his shgb levels are low? My shgb is at 12.....so what should I be seeking for E2 levels? Thanks

Ive also heard it may be advantageous to have E2 mirror free T, or preferably, have free T slightly higher. You can try matching those instead, to see if that works better for you
 
My sensitive E2 is 25.4 and FT 17.8.Maybe I should try and drop E2 just a little?

Ya maybe. But I personally wouldn’t lower it with an ai. The only way I would lower E2 is with a DHT derived compound, like oxandrolone (anavar), or possibly nandrolone. I would try using low dose anavar first though, if just lowering your E2 is the goal.
 
I’ve read many posts about how your Estrogen levels should mirror your shgb levels. What is a guy to do if his shgb levels are low? My shgb is at 12.....so what should I be seeking for E2 levels? Thanks
It is true for some members. I'm not one of them, I have higher shbg and never have been concerned with my E2 levels.
 
Ive also heard it may be advantageous to have E2 mirror free T, or preferably, have free T slightly higher. You can try matching those instead, to see if that works better for you

My shbg is anywhere from 40-73 while my E2 has been between 5-56, though usually E2 is from 15-30 depending on Total T.

If I look at TruT, then often the calculated free T is similar to E2 sensitive.

However, I mostly only pay attention to total T even though I test for shbb/E2.
 
My SHBG is 7! Estradiol sensitive is 37. The lab didn’t process my testosterone labs as the sample wasn’t sufficient. I will get another draw and report back.
 
My SHBG is 7! Estradiol sensitive is 37. The lab didn’t process my testosterone labs as the sample wasn’t sufficient. I will get another draw and report back.
Interested in following your progress. I have been battling HRT for many years and now I believe my low SHBG has been my main culprit. Im going to start with Defy and see if they can get me on the right track.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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