Please comment on my first TRT Protocol:

After asking if the doc could split my dose into twice a week here is the protocol he recommended:

Sunday evening: 75mg Test C taken intramuscularly
Monday morning: .25mg HCG taken sub-Q
Tuesday: 0.5mg Anastrozole
Wednesday morning: 75mg Test C taken intramuscularly
Thursday morning: .25mg HCG taken sub-Q
Friday, Saturday: off

A little about me: 35y, 6’3”, 205lb, ~10%bf, low free T, high SHBG, mid range Estradiol.

How would the experts here rate this protocol? Am I at risk for crashing my E2 by starting Anastrozole the first week? Is it better to start an AI once high-estrogen symptoms present themselves?
 
You’re assuming high estrogen is any sort of an issue whatsoever, even if you do end up having it. Mine is 73, I know plenty with higher than that. Give it time, those “issues” usually go away on their own

I’d start with T only. 150mg/week is fine. I’d do 50mg 3x a week but you can try twice a week too.

I wouldn’t start with HCG Unless you’re actively trying to conceive
 
I would hold off on the AI and wait to see if you have symptoms.

i started with twice weekly and felt best on EOD. But everyone if different.

i am also a high SHBG guy....70+.

Good luck.
 
Hi.

I know trt is a large commitment, but why does not men prefer a less is more protocol. Too much hassle having to inject x that day and x amount of that compound that day.. I rather spend 5 minutes injecting 56iu Nebido every Sunday. That is the only compound I use. When having children I start using other medication alongside Nebido.

Have a great day.
 
You’re assuming high estrogen is any sort of an issue whatsoever, even if you do end up having it. Mine is 73, I know plenty with higher than that. Give it time, those “issues” usually go away on their own

I’d start with T only. 150mg/week is fine. I’d do 50mg 3x a week but you can try twice a week too.

I wouldn’t start with HCG Unless you’re actively trying to conceive
It would be nice to see your pre trt labs. My first trt protocol was 70 mg of testosterone cypionate twice a week along with 500 IU of HCG. I injected both on the same day. No AI. It did work great for me.
 
It would be nice to see your pre trt labs. My first trt protocol was 70 mg of testosterone cypionate twice a week along with 500 IU of HCG. I injected both on the same day. No AI. It did work great for me.

Thank you, what would be helpful to see in my labs? My SHBG ranged from 53.4-57.2 nmol/L from 4 blood tests.
Also did you use a single injection with both the test and HCG?
 
If you’re legit 10% body fat, estrogen conversion is even less of an issue. Hate seeing guys get started on an ai, terrible medical practice. Even if estrogen comes back out of range, you likely won’t have any symptoms anyways

Thanks, didn't realize estrogen was less of an issue for lower body fat. By May I yearly target in the 7% range.
 
It would be nice to see your pre trt labs. My first trt protocol was 70 mg of testosterone cypionate twice a week along with 500 IU of HCG. I injected both on the same day. No AI. It did work great for me.
Not sure if you meant this to me or the OP?

The basics for me, pre TRT, was:

Total T, 862 [264 - 916]
Free T, 6.3 [8.7 - 25.1]
TSH, 2.64
LH, 3.1
Estradiol, 13.1 [8 - 35]
SHBG, 151 [17 - 56]
 
Thank you, what would be helpful to see in my labs? My SHBG ranged from 53.4-57.2 nmol/L from 4 blood tests.
Also did you use a single injection with both the test and HCG?
Yes, I used both in a single injection. I watched Nelson's video many times over, with him injecting both in the same syringe.
 
Not sure if you meant this to me or the OP?

The basics for me, pre TRT, was:

Total T, 862 [264 - 916]
Free T, 6.3 [8.7 - 25.1]
TSH, 2.64
LH, 3.1
Estradiol, 13.1 [8 - 35]
SHBG, 151 [17 - 56]
No, the reply wasn't meant for you. It's nice that your estrogen is so low. Hopefully you can lower your shpg.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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