Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene

Just want to add my protocol.... I take 20mg of Test Cyp on MWF (down from 60mg) along with 250 IU of HCG and 75 IU of HMG. My total T last draw was 1100 and Free T 244. E2 is always 60-70 without symptoms and I do not take any Anastrozole. Adding the HCG and HMG brought me from a completely absent sperm count to 15 million fully functional swimmers on my last analysis. I was able to become fertile without stopping TRT.
 
Is there anyone who has tried infrequent large doses of gonadorelin? Curious if gonadorelin is enough to prevent testicular shrinkage if taken daily or even eod-e3d.
In my country it's only available for cows, dont know if i could identify as one and get it prescribed, but it is 50micrograms per ml, larger doses might be problematic subq.
 
Is there anyone who has tried infrequent large doses of gonadorelin? Curious if gonadorelin is enough to prevent testicular shrinkage if taken daily or even eod-e3d.
In my country it's only available for cows, dont know if i could identify as one and get it prescribed, but it is 50micrograms per ml, larger doses might be problematic subq.
As mentioned later in this post on the previous page, Royal Medical Center is or was using such protocols. I haven't noticed patients of theirs making comments here, but it's possible there are reports elsewhere. It would be good to know if the relatively infrequent, but robust pulses of LH and FSH are sufficient to prevent testicular atrophy. I don't recall if we nailed down the exact protocol, but I believe it was either 50 or 100 mcg taken once or twice a week.
 

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HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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