Low e2 - Lethargy, Lack of motivation and heartburn (acid reflux)

Mathostx

New Member
My main symptom that I felt after starting TRT (second day) is crazy heartburn.

Some people mentioned my e2 is low some say the jump in T caused the release of stomach peptides that increase stomach acid production. Which it kind of makes sense since I experienced (still do) extreme hunger all the time. But the stomach holds acid all the time and it empties it upon digesting food into chyme so.. why would I be experiencing acid reflux?

These are my values after 4 weeks:

E2 - 13 ( range 15-30) pg/ml
Test - 822
Free Androgen Index - 75
SHBG - 38 nmoL/L

Is it my e2 or T?
I pin 2x a weel for a total of 100mg. Test C. No other medications.
5'10 - 160 lbs, I exercise every day.

What could it be, I'm desperate.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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