Letting e2 run wild

[Zooulie12]

My old dr was a dr who was all about not treating E2. He said let it go as high as you want and it won’t be a problem. Well I am seeing a new dr now and my e2 sensitive was 45.
My libido has been super low, my anxiety kind of high, also my junk shrivels up to nothing along with my scrotum, crying randomly. I get people on this forum always ask for more info as far as it could be something else.

But I guess my question is, from you’re guys experience when your e2 is this high do you get the same issues? Because from what I’ve read on a non sensitive test my levels would be like in the 90s

 

[MarcoFL]

Can you share your protocol and labs?

 

[buckeye22]

My old dr was a dr who was all about not treating E2. He said let it go as high as you want and it won’t be a problem. Well I am seeing a new dr now and my e2 sensitive was 45.
My libido has been super low, my anxiety kind of high, also my junk shrivels up to nothing along with my scrotum, crying randomly. I get people on this forum always ask for more info as far as it could be something else.

But I guess my question is, from you’re guys experience when your e2 is this high do you get the same issues? Because from what I’ve read on a non sensitive test my levels would be like in the 90s

Your old dr is right. Your E2 is not the problem. Those are not high E2 symptoms and 45 is nothing. Your problem lies elsewhere. What’s your free T and total T numbers? What’s your SHBG number? Maybe try a daily cialis added to your regimen.

 

[Zooulie12]

Your old dr is right. Your E2 is not the problem. Those are not high E2 symptoms and 45 is nothing. Your problem lies elsewhere. What’s your free T and total T numbers? What’s your SHBG number? Maybe try a daily cialis added to your regimen.

What are they then? When I looked them up it seemed they were. Water retention as well. Insomnia. I’ve seen a lot of guys on this site TRT to monitor their E2 and keep it at a certain range because of it getting too high. But I asked for you’re guys opinion and you gave it to me that’s fair. Mind you the e2 test was a sensitive test

 

[Zooulie12]

Can you share your protocol and labs?

Total t-1444
Free T 46
Dht- 146
Igf1-180
Dhea-186
E2 sensitive- 46.1 ( I had to re look it up to make sure I was giving the right number)

protocol is .8 ED or EOD and 50mg of T cream 2-3 times a week.

I am speaking with my new provider on Monday and seeing if a real low dose of an AI might be worth considering. Low as in .1 or .125

 

[madman]

Total t-1444
Free T 46
Dht- 146
Igf1-180
Dhea-186
E2 sensitive- 46.1 ( I had to re look it up to make sure I was giving the right number)

protocol is .8 ED or EOD and 50mg of T cream 2-3 times a week.

I am speaking with my new provider on Monday and seeing if a real low dose of an AI might be worth considering. Low as in .1 or .125

From your previous thread.

High Testosterone and anxiety

So I got some Of my labs back and the basics are my T was 1477 Free T-47 SHGB was 30 Hemocrit was 51 Hemoglobin was 17 IGF-1 was 180 PSA-0.6 this was done 24 hours after my last injection. I do 25mg everyday. But my question is, my anxiety has been a little on the higher side lately. I know...

www.excelmale.com

Current protocol .8ED or EOD...which is it?

What dose of T are you injecting daily or EOD?

If you are still hitting a trough TT 1400-1500 ng/dL then your FT is going to be absurdly high as your SHBG was only 30 nmol/L!

Again post full labs including RBCs/hemoglobin/hematocrit.

Even then you need to have your FT tested using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration to know where your FT level truly sits on such protocol.

Regardless if you are hitting a trough TT 1400-1500 ng/dL on EOD injections let alone hitting 1400-1500s on dailies then you can rest assured that your FT is through the roof!

If you truly feel that your e2 is too high then it is a no-brainer that you have room to lower your weekly T dose a little and bring down your FT which will drop your e2.

Yet you would rather hop on an AI?

 

[Tman]

and, to piggy back, I imagine those numbers don't include the cream you are adding on top of the injections. On the flip side, when my E is that high, I have those same side effects...though my T has never been that high...oh, and for a few days after changing my dose.

 

[Zooulie12]

From your previous thread.

High Testosterone and anxiety

So I got some Of my labs back and the basics are my T was 1477 Free T-47 SHGB was 30 Hemocrit was 51 Hemoglobin was 17 IGF-1 was 180 PSA-0.6 this was done 24 hours after my last injection. I do 25mg everyday. But my question is, my anxiety has been a little on the higher side lately. I know...

www.excelmale.com

Current protocol .8ED or EOD...which is it?

What dose of T are you injecting daily or EOD?

If you are still hitting a trough TT 1400-1500 ng/dL then your FT is going to be absurdly high as your SHBG was only 30 nmol/L!

Again post full labs including RBCs/hemoglobin/hematocrit.

Even then you need to have your FT tested using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration to know where your FT level truly sits on such protocol.

Regardless if you are hitting a trough TT 1400-1500 ng/dL on EOD injections let alone hitting 1400-1500s on dailies then you can rest assured that your FT is through the roof!

If you truly feel that your e2 is too high then it is a no-brainer that you have room to lower your weekly T dose a little and bring down your FT which will drop your e2.

Yet you would rather hop on an AI?

I feel like everyone thinks AIs are the devil from ive heard. Even on super low doses. “Everyone” is sort of a generalization

 

[MarcoFL]

I feel like everyone thinks AIs are the devil from ive heard. Even on super low doses. “Everyone” is sort of a generalization

NO. but what on earth are you taking so much to have your levels there? Listen to the old guys here LESS is better.

 

[madman]

I feel like everyone thinks AIs are the devil from ive heard. Even on super low doses. “Everyone” is sort of a generalization

Search results

www.excelmale.com

You have been at this since you first starting posting in 2018 caught up on managing your e2 with the use of an AI let alone struggling with libido/ED issues!

Read through every post as it is clear as day.

You were running a trough TT in the 1000s ng/dL back then which would have had your trough FT levels high as your SHBG was only 30 nmol/L.

Peak levels would have been much higher.

Now you are running a trough TT 1400-1500 ng/dL which would have your FT absurdly high.....go figure!

You started trt in 2015 when you were 24 years old.

Never once posted your pre-trt labs on here.

Most men suffering from low-t symptoms that do not have high SHBG have TT levels in the 200-400 ng/dL range with lowish/low FT.

Driving up TT in the high 900s-->low 1000s would easily allow one to achieve a healthy FT level and in many cases high FT!

You basically went from having low-T (most likely 200-400 ng/dL range) to jacking it up on the higher end (trough 1000 ng/dL) which would have your FT level high.

Now you went and jacked your levels up further by running a TT 1400-1500 ng/dL (trough?) which again would have your FT levels absurdly high as your SHBG of 30 nmol/L is normal.

You must be dead set on the more T is better mentality!

Need to give your head a shake and think more deeply on this one.

 

[Jon H]

These E2 threads will never die...and there will always be well-minded and educated input from pro-AI and anti-AI camps. To answer your original question, if my E2 is 45 I have all of those symptoms, and it's awful. I need to keep my E2 below 35 regardless of where my total and free T levels are. Plenty of other men on this forum will feel better with higher E2. I'm not one of them, and you might not be either.

Don't let forum members determine where your E2 should be (including myself). Figure out what works for you, take responsibility for your decisions, and adjust when necessary.

 

[Zooulie12]

Search results

www.excelmale.com

You have been at this since you first starting posting in 2018 caught up on managing your e2 with the use of an AI let alone struggling with libido/ED issues!

Read through every post as it is clear as day.

You were running a trough TT in the 1000s ng/dL back then which would have had your trough FT levels high as your SHBG was only 30 nmol/L.

Peak levels would have been much higher.

Now you are running a trough TT 1400-1500 ng/dL which would have your FT absurdly high.....go figure!

You started trt in 2015 when you were 24 years old.

Never once posted your pre-trt labs on here.

Most men suffering from low-t symptoms that do not have high SHBG have TT levels in the 200-400 ng/dL range with lowish/low FT.

Driving up TT in the high 900s-->low 1000s would easily allow one to achieve a healthy FT level and in many cases high FT!

You basically went from having low-T (most likely 200-400 ng/dL range) to jacking it up on the higher end (trough 1000 ng/dL) which would have your FT level high.

Now you went and jacked your levels up further by running a TT 1400-1500 ng/dL (trough?) which again would have your FT levels absurdly high as your SHBG of 30 nmol/L is normal.

You must be dead set on the more T is better mentality!

Need to give your head a shake and think more deeply on this one.

I’m sorry but you’re actually wrong about me thinking more T is better. My protocol is 120mgs a week. So it’s not like I am blast 300mgs a week of T in me.
But I’m confused with what you’re saying about the T. Are you saying too much can be a bad thing effecting someone with libido issues. Yes I have been on the board for awhile. But it comes in waves. Where I go through times of feeling great then times of not great. A protocol will work for awhile then it seems it stops working.

I also use to be on suboxone (quit cold turkey 10 days ago) and I sometimes wonder if even though I’m on HRT if that’s played a major role in the fluctuation of my sex drive

 

[madman]

I’m sorry but you’re actually wrong about me thinking more T is better. My protocol is 120mgs a week. So it’s not like I am blast 300mgs a week of T in me.
But I’m confused with what you’re saying about the T. Are you saying too much can be a bad thing effecting someone with libido issues. Yes I have been on the board for awhile. But it comes in waves. Where I go through times of feeling great then times of not great. A protocol will work for awhile then it seems it stops working.

I also use to be on suboxone (quit cold turkey 10 days ago) and I sometimes wonder if even though I’m on HRT if that’s played a major role in the fluctuation of my sex drive.

No, I was not saying you are on a high dose of T.

When I state the more T is the better mentality I mean running absurdly high TT/FT levels.

Run what levels you feel are best but if you are struggling with sides then you easily have room to lower your levels and bring down your FT.

Again.....if you truly feel that your e2 is too high then it is a no-brainer that you have room to lower your weekly T dose a little and bring down your FT which will drop your e2.

Yet you would rather hop on an AI?

Too many are dead set that absurdly high FT levels 50-60 ng/dL are needed to feel well and in many cases, it can lead to numerous issues.

 

[Gingkohagane]

some do like the emotional effects of E2. it depends on the individual

 

[Zooulie12]

No, I was not saying you are on a high dose of T.

When I state the more T is the better mentality I mean running absurdly high TT/FT levels.

Run what levels you feel are best but if you are struggling with sides then you easily have room to lower your levels and bring down your FT.

Again.....if you truly feel that your e2 is too high then it is a no-brainer that you have room to lower your weekly T dose a little and bring down your FT which will drop your e2.

Yet you would rather hop on an AI?

Too many are dead set that absurdly high FT levels 50-60 ng/dL are needed to feel well and in many cases, it can lead to numerous issues.

Okay, that makes sense on what you’re saying. Sorry I was just kind of confused. I do wonder if my suboxone has played a role on the ups and downs. I’ve done a couple searches on here and it seems not too many are on it. Along with searches on Reddit about how people felt while on it during HRT

 

[swoops36]

Okay, that makes sense on what you’re saying. Sorry I was just kind of confused. I do wonder if my suboxone has played a role on the ups and downs. I’ve done a couple searches on here and it seems not too many are on it. Along with searches on Reddit about how people felt while on it during HRT

Suboxone absolutely can. Have you had your prolactin levels checked?

 

[Zooulie12]

Suboxone absolutely can. Have you had your prolactin levels checked?

No, but that’s one thing I was just reading as well. From what I’ve read once the opiates get off your receptors levels can get to normal. The main reason for getting off the subs was because of this whole issue of this horrible balancing act with my hormone therapy.

 

[swoops36]

No, but that’s one thing I was just reading as well. From what I’ve read once the opiates get off your receptors levels can get to normal. The main reason for getting off the subs was because of this whole issue of this horrible balancing act with my hormone therapy.

I’m on a low dose as well, haven’t had any issues, been 3 years now. But I take P5P daily as well. As far as time off, the Sub HL is pretty long, would take a couple weeks to clear completely

 

[Zooulie12]

I’m on a low dose as well, haven’t had any issues, been 3 years now. But I take P5P daily as well. As far as time off, the Sub HL is pretty long, would take a couple weeks to clear completely

Yeah I was really never taking anything for (possible) high prolactin. I was on 4-6mg daily. What dose are you on ?

 

[Zooulie12]

Yeah I was really never taking anything for (possible) high prolactin. I was on 4-6mg daily. What dose are you on ?

I’m taking l-dopa for the withdrawals. But from what I have read it seems like p5p is pretty popular when on therapy.