Kyzatrex or Jatenzo

[charile12]

Good day all. I've been on testosterone cypionate almost 7 years. I inject anywhere from 100 to 120 mg in total divided 2 times a week. Am 47.
I'm feeling good consistently for years now.

Looks like my insurance cover oral testosterone.
I did read some threads on here, I see system Lord is doing well on jatenzo. I'm looking to see if I should switch to oral.

I'm just looking for people's experience on either of these two orals
Kyzatrex or Jatenzo. Any clear winner?
Thank you.

 

[Systemlord]

I'm just looking for people's experience on either of these two orals
Kyzatrex or Jatenzo. Any clear winner?

I believe Jatenzo has a slight advantage in the half-life department and levels achieved. If it comes down to cost, cash for treatment, the clear winner is Kyzatrex.

If you're looking for personal experiences on oral testosterone, feedback will be extremely limited as we are in the minority.

Many doctors aren't even aware oral testosterone exists.

I inject anywhere from 100 to 120 mg in total divided 2 times a week. Am 47.
I'm feeling good consistently for years now.

Why mess with success?

 

[charile12]

I thought I saw that with jatenzo you need to take with a fatty meal not with Kyz.

Just exploring. Yeah I may not want to rock the boat...

 

[madman]

Good day all. I've been on testosterone cypionate almost 7 years. I inject anywhere from 100 to 120 mg in total divided 2 times a week. Am 47.
I'm feeling good consistently for years now.

Looks like my insurance cover oral testosterone.
I did read some threads on here, I see system Lord is doing well on jatenzo. I'm looking to see if I should switch to oral.

I'm just looking for people's experience on either of these two orals
Kyzatrex or Jatenzo. Any clear winner?
Thank you.

There is no clear winner.

You have 3 options when it comes to oral T (Jatenzo, Tlando, and Kyzatrex).

All 3 formulations use esterified T (testosterone undecanoate) in a self-emulsifying drug delivery system (SEDDS) formulation.


*TU has been integrated into a new proprietary SEDDS formulation. SEDDS stimulates a level of saponification of the lipophilic T esters, which leads to more preferential absorption by the intestinal lymphatic system. This leads to a decrease in first-pass hepatic metabolism.23 SEDDS formulations syndicate lipophilic and hydrophilic components, which promote the solubilization of molecules such as TU, which are normally lipophilic. Thus, they can be absorbed in the intestines without the necessity of maintaining a diet high in fat content.324

*SEDDS is defined as a uniform amalgam of lipophilic oils (synthetic or natural) plus solid or liquid surfactants or hydrophilic solvents. On activation followed by a reduction in aqueous solution, which is what happens in the human gastrointestinal tract, these systems produce a fine oil in water emulsion, which is physically stable (unlikely to be degraded or absorbed through the portal system) and readily absorbed by the intestines to the bloodstream.25


They all contain castor oil and the PKs are similar.

Would not get too caught up on the peak/troughs achieved.

Dosage used/absorption is what matters.

You should be able to hit a high-end/high peak on such which is short-lived and troughs levels will be nothing to brag about.

2 daily peaks/troughs!

If it were me I would go with the cheapest option.

The cost for Jatenzo is absurd and luckily they were forced to offer a pay-out-of-pocket option recently due to trying to stay competitive with Kyzatrex and Tlando which already offered such.

Keep in mind if your goal is to take advantage of the anabolic properties of T then injectables are where it's at as one can easily attain high/absurdly high trough FT levels.

When it comes to reaping the full anabolic benefits not only is having supra-physiological levels of FT steady-state 24/7 important but also how high you drive up FT levels.

When it comes to packing on size/mass/strength T is king!




KYZATREX

KYZATREX (testosterone undecanoate) capsules for oral use are available in three dosage strengths- 100 mg, 150 mg, and 200 mg. The 100 mg strength is an opaque, white capsule imprinted with “MP100” in red ink. The 150 mg strength is an opaque white capsule imprinted with “MP150” in red ink. The 200 mg strength is an opaque white capsule imprinted with “MP200” in red ink. All capsule strengths also contain DL-alpha-tocopheryl acetate (Vitamin E), phytosterol esters, polyoxyl 40 hydrogenated castor oil, and propylene glycol monolaurate as inactive ingredients.

Gelatin capsule shells are composed of the following inactive ingredients: gelatin, glycerin, purified water, sorbitol, and titanium dioxide.

*The average daily NaF/EDTA plasma testosterone concentration was 393.3 (±113.6) ng/dL after 90 days of treatment (normal eugonadal range in NaF/EDTA plasma: 222-800 ng/dL.

*The percentage of patients who received KYZATREX and had testosterone Cmax threshold less than or equal to 1200 ng/dL, between 1440 and 2000 ng/dL, and greater than 2000 ng/dL at the final PK visit were 88%, 4%, and 0%, respectively.








JATENZO

JATENZO capsules are available in three strengths 158 mg, 198 mg, and 237 mg.

The 158 mg strength is an opaque red capsule that contains 158 mg of testosterone undecanoate and is imprinted with “158” in white ink. The 198 mg strength is an opaque white capsule that contains 198 mg of testosterone undecanoate and is imprinted with “198” in red ink. The 237 mg strength is an opaque orange capsule that contains 237 mg of testosterone undecanoate and is imprinted with “237” in white ink. All capsule strengths also contain oleic acid, polyoxyl 40 hydrogenated castor oil (Cremophor RH 40), borage seed oil, peppermint oil, and butylated hydroxytoluene as inactive ingredients.

Gelatin capsule shells are composed of the following inactive ingredients: Gelatin, sorbitol, glycerin, purified water, iron oxide red, FD&C Yellow #6, and titanium dioxide.


*The average daily NaF-EDTA plasma testosterone concentration was 403 (± 128) ng/dL at the end of treatment, whereas the normal eugonadal range in NaF-EDTA plasma was 252-907 ng/dL in this study.

*The percentage of patients who received JATENZO and had Cmax less than or equal to 1500 ng/dL, between 1800 and 2500 ng/dL, and greater than 2500 ng/dL at the final PK visit were 83%, 3%, and 3%, respectively.

Testosterone Update on Oral Products

T. Mike Hsieh, MD, MBA, a professor in the Department of Urology at the University of California San Diego (UCSD) School of Medicine and Director, of the Men's Health Center at UCSD Health provides an update on available oral testosterone treatments, their efficacy, and risks involved and...

www.excelmale.com

The Evolving Role of Novel Oral Agents for TRT

The Evolving Role of Novel Oral Agents for Testosterone Replacement Therapy; A Historical Perspective (2022) Pratik Kanabur, Robert Brunner, Dalia Khera, Hunter A. Flores, and Mohit Khera* Abstract There have been multiple attempts at an oral testosterone option for men with testosterone...

www.excelmale.com

A pill that could outsell Viagra: New testosterone Rx drug

So this is an oral testosterone undecanoate.

www.excelmale.com

email on Oral Testosterone

Had this email come to me today. Got me wondering what the drug is called. Think it is the known orals like Kyzatrex? I imagine you all don't agree that what he is saying is accurate. Sounds too good to be true. Thoughts? (email body) An industry changing new technology has just arrived...

www.excelmale.com

Erythrocytosis Associated With Oral Testosterone Replacement

Abstract Background A growing prevalence of male hypogonadism has led to increased interest in the most common adverse event, erythrocytosis. Defined by hematocrit (HCT) > 49-51%, the incidence varies depending on the testosterone formulation.3 The formulations with the lowest risk of...

www.excelmale.com

Oral TRT Products: Jatenzo, Tlando, Kyzatrex, & DiTest

Testosterone Replacement Therapy: A Narrative Review with a Focus on New Oral Formulations (2022) Salman Z Bhat and Adrian S Dobs Male hypogonadism affects 10–30% of the male population and is often under-recognized and under-treated. Different replacement formulations exist, each with...

www.excelmale.com

Oral Testosterone: The New Frontier of TRT

https://www.prostatehealthpodcast.com/84-oral-testosterone-the-new-frontier-of-testosterone-replacement-therapy-with-wayne-kuang-md/#testosterone We are excited to partner with Marius Pharmaceuticals for today’s podcast and have Dr. Wayne Kuang joining us as our featured guest! Until...

www.excelmale.com

Testosterone: Navigating Options & Implementation in Clinical Practice

Great interview! Very thorough. This video discusses the importance of men’s health and the role of urologists in addressing conditions like testosterone deficiency. Key Takeaways: *Dr. Andrew Sun provides an overview of different testosterone treatment options, including both internal...

www.excelmale.com

 

[Jcilla]

Can someone please help me with dosing protocol- I wake up at 5am and workout at 5:30. I eat breakfast after the gym at about 7am and then eat dinner at 5:30pm. Should I take the first dose when I wake up or with breakfast?

 

[Systemlord]

Should I take the first dose when I wake up or with breakfast?

Take it with your meal. I have taken my doses 14 hours apart getting home late. I don’t notice feeling any different unless I go several hours late, and even then it’s a slight difference.

If I completely miss my evening dose, I wake up feeling a little off, sleep wasn’t the best, for from bad, only to find my evening Jatenzo still in the pm pill container.

I count myself as super sensitive to hormone fluctuations, your mileage may vary.

 

[Jcilla]

Take it with your meal. I have taken my doses 14 hours apart getting home late. I don’t notice feeling any different unless I go several hours late, and even then it’s a slight difference.

If I completely miss my evening dose, I wake up feeling a little off, sleep wasn’t the best, for from bad, only to find my evening Jatenzo still in the pm pill container.

I count myself as super sensitive to hormone fluctuations, your mileage may vary.

Thanks for the response. So there is no real benefit to taking it pre workout?

 

[Systemlord]

I thought I saw that with jatenzo you need to take with a fatty meal not with Kyz.

Since starting the carnivore diet, I have noticed higher testosterone levels on Jatenzo. I’m still at 401 ng/dL at 9 hours whereas my previous 6 hour level was 450 ng/dL.

I typically see minus 100 ng/dL per hour.

 

[Systemlord]

Thanks for the response. So there is no real benefit to taking it pre workout?

I couldn’t fathom not taking my testosterone before my workout.

 

[Jcilla]

I couldn’t fathom not taking my testosterone before my workout.

That’s what I was thinking. I just didn’t know if there was enough time for the test to absorb from the time I woke up til my workout

 

[Systemlord]

I just didn’t know if there was enough time for the test to absorb from the time I woke up til my workout

Testosterone starts increasing almost immediately, it just takes 2 hours to reach peak.

 

[Jcilla]

Testosterone starts increasing almost immediately, it just takes 2 hours to reach peak.

Got it- so if I took my first dose at 5am when should I take my second?

 

[madman]

Can someone please help me with dosing protocol- I wake up at 5am and workout at 5:30. I eat breakfast after the gym at about 7am and then eat dinner at 5:30pm. Should I take the first dose when I wake up or with breakfast?

Just take it with your meal.

If you get up at 5 am and workout 1/2 hr later highly doubtful you will get any benefit as Tmax is achieved 2-4 hrs following your am dose and 4 hrs after your pm dose.

Unesterified Nasal T gel (Natesto) will hit your system much faster as the Tmax is approximately 40 minutes.

 

[Systemlord]

Got it- so if I took my first dose at 5am when should I take my second?

Every 12 hours.

 

[Ravenouz]

DO we have a winner out of these 3 options? Anyone?

 

[Systemlord]

DO we have a winner out of these 3 options? Anyone?

Jatenzo has the half-life advantage and slightly higher peak levels.

The question becomes will you even notice a difference?

 

[madman]

DO we have a winner out of these 3 options? Anyone?

There is no clear winner!

Again!

They all contain castor oil and the PKs are similar.

Would not get too caught up on the peak/troughs achieved.

Dosage used/absorption is what truly matters!

KYZATREX (oral testosterone undecanoate) now available in all states across the US

Did you get any nasty side effects by the way? None. I am looking at all the warnings and one of them says increase risk of death. That's a load of sh**! There's an increase risk of death living life, like crossing the street. There's increase risk of death with any other medicines.

www.excelmale.com

 

[MarcoFL]

I am at a total loss why you would change if you are so happy with what has worked.

 

[Nelson Vergel]

 

[licor22]

Hi guys. New here. 32 y/o. I recently had some testosterone blood work done and my total T was at 267. My endo said since its still within the normal ranges i don't need trt. But i feel tired fatigued all the time and i feel i need it. Firstly thoughts on that ? Secondly which way would be the best route to go, oral or injectables and thirdly i have high ldl so should is that going to be elevated as i read somewhere that it will ?