How Your Circadian Clock Genes Affect Your Testosterone- Deep Dive

This Beyond Testosterone podcast episode comes from an academic review article from the Asian Journal of Andrology, published in September-October 2025. This article, titled "Regulation of testosterone synthesis by circadian clock genes and its research progress in male diseases," examines the relationship between circadian rhythms and testosterone production in males. It explores how circadian clock genes centrally and peripherally regulate testosterone synthesis and secretion, and how disruptions in these rhythms are linked to various male health issues, including late-onset hypogonadism, erectile dysfunction, male infertility, and prostate cancer. The authors also discuss potential therapeutic approaches, such as chronotherapy and non-pharmacological interventions, for these conditions based on circadian rhythmicity. The episode concludes by highlighting current limitations in research and suggesting future directions for investigation.

Reference: Regulation of testosterone synthesis by circadian clock... : Asian Journal of Andrology

 

Thread 'Factors influencing testosterone levels in men'

Oct 21, 2020

The causes of adverse changes of testosterone levels in men



Abstract

Introduction: As men age, progressive testosterone deficiency syndrome becomes an increasingly common problem. However, the decreased testosterone levels are not only the result of advanced age.

Areas covered: PubMed search of published data on testosterone, nutritional deficiency, stress, sleep, and obesity. Many factors impact the male HPG axis (the hypothalamic-pituitary-adrenal), including body weight, calorific, and nutritional value of a diet, the amount and quality of sleep, as well...

• madman
• factors influencing testosterone levels in men
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More information: Circadian variation in systemic hormone levels in healthy men - Excel Male Men's Health Forum