hCG, hot flash, dry mouth/eyes, anxiety side effects

[gerardo]

I found this on an old post from another site. It discusses the cortisol link.
This study was pointed out in a previous article written by Patrick Arnold.

"There is an enzyme that is localized primarily in the kidneys whose function is to protect the kidneys from circulating cortisol. The kidneys have receptors called mineral corticoid receptors (MR’s) which are meant to bind to specific adrenal hormones (called mineralcorticoids) in the body such as aldosterone. The result of this binding is a signal to increase sodium and water retention in the body, while stimulating the excretion of potassium. This is an important mechanism to maintain fluid and electrolyte balance in the body.

A problem exists though in that cortisol can also bind activate these receptors. Cortisol is a widely circulating hormone and serves a multitude of functions throughout the body. However its intended biological functions do not include mineralcorticoid action in the kidneys, so to prevent this from happening the kidneys are rich in the enzyme 11b-hydroxysteroid dehydrogenase 2 (11b-HSD2). This enzyme deactivates cortisol by converting it into cortisone before it can bind to the renal MRs."

[IMG alt="11 beta HSD 2.jpg"]https://aws1.discourse-cdn.com/tnation/uploads/default/original/3X/a/7/a7fc3e8cb17f74c6a5b0e6090cc6febb24164b1b.jpeg[/IMG] 3

Testosterone and anabolic steroids have been shown to inhibit 11b-HSD2.

Here’s how it works: throughout the course of the day, the adrenal gland releases the hormone cortisol, either due to normal circadian (daily) and ultradian (hourly) rhythms or in reaction to stress. Cortisol is an important stress hormone, but many of its effects, while good in a fight-or-flight scenario, are bad over time in terms of diabetes and obesity: cortisol increases glucose production and release in the liver; increases appetite in anticipation of any necessary reaction to the stress-causing situation; and alters metabolic processing such that fat is preferentially stored in the central abdominal region. So, for diabetics, this means stored glucose directly increases blood sugar, new calories are ingested and increase both blood sugar and weight, and, to top it all off, the new weight tends to be the “bad,” visceral, disease-causing weight.

There are a couple of therapeutically important pit-stops for cortisol throughout this process, though; the active hormone cortisol can be converted in the kidney, colon, and some other tissues into the inactive molecule cortisone. The enzyme 11 beta-HSD2 aids this conversion, and allows cortisol to be stored out of the bloodstream.

Inhibiting 11b-HSD 2 can cause glucocorticoid-mediated MR activation, potassium excretion, sodium and water retention, and increased blood pressure. "

Thank. In this case, for patients who have low cortisol when undergoing TRT, would they have to take hydrocortisone? Many cases happen to have Adrenal Fatigue and the cortisol is very low.

 

[NL77]

Could you explain a little about cortisol? After all, does HCG really cause anxiety due to increased E2? I already take Arimidex + Hcg + Tes cyp and the anxiety symptoms continued?

Have you had your E2 taken?

 

[gerardo]

Have you had your E2 taken?

I didn't touch E2.

 

[NL77]

I didn't touch E2.

Arimidex can lower your estradiol to much. Low estradiol can cause anxiety as well. May want
To have it tested or you can get
It tested yourself. Low estradiol can be worse than high estradiol especially with anxiety. Dr Saya told me a couple of years ago that 1
Mg of arimidex can lower your estradiol by 80% in 48 hrs in some people. When I stopped arimidex I felt great but it
Was based on a low estradiol. I’ve had estradiol up in the 50’s and felt fine too. But low was bad

 

[gerardo]

Arimidex can lower your estradiol to much. Low estradiol can cause anxiety as well. May want
To have it tested or you can get
It tested yourself. Low estradiol can be worse than high estradiol especially with anxiety. Dr Saya told me a couple of years ago that 1
Mg of arimidex can lower your estradiol by 80% in 48 hrs in some people. When I stopped arimidex I felt great but it
Was based on a low estradiol. I’ve had estradiol up in the 50’s and felt fine too. But low was bad

I never used arimidex. I believe it is better not to download my E2. He is not very tall, but I need to see the issue of Prostatic Hyperplasia + TRT.

 

[gerardo]

This issue of cortisol and Hcg needs to be further studied.