HCG DOSE FREQUENCY FOR MEN - FERTILITY & TESTICULAR ATROPHY

Hi everybody.
I would like to hear from people having experience (or having knowledge) on different hcg dose frequency protocols. Basically I want to know if every day lower dose has any different outcome, better o worse, compared to every other day, every 3 days, twice weekly etc. I mean, same weekly dose but different frequencies.
My motivation is that I am looking for fertility, but I am very sensitive to estradiol, and hcg gives me plenty. So I would prefer smaller but daily doses. In other hand, I wonder if such a daily dose would impair leydig cells respond being flooded constanty at their LH receeptors...

 

then there are reports of some guys cruising on hcg mono on doses such as 250iu 3xweek, 500iu 2xweek. There are no studies validating the claim that hcg mono works only with higher doses, supraphysiological ITT was always required for fertility when rFSH was not used. Would be nice to have a study comparing 250, 500, 1000, 1500 eod effect on testosterone levels and e2, progesterone etc...

It's funny how the shot day of hcg there is always more libido, even though the effect on testosterone follows behind.

add Anastrozol and recover libido and can skip pde5i for first time in years, then sperm quality not good yet, stop trt (This is currently), and stay HCG monotherapy (780 IU ovitrelle every 3rd day) + rFSH + Anastrozol, results: testicles bigger and hanging more than I can recall, Libido getting better progressively after a dramatic fall.

Update: during the last month HCG Monotherapy dose (Ovitrelle) has being 790 IU M, W, F. with Anastrozole 0.25 mg M,W.F.
HCG has always been a nightmare for me regarding libido and ED. This time is completely different, I have great libido, and ED has improved dramatically, almost no need for PDE5i (only 25 mg sildenafil, before was 100 mg plus daily tadalafil). Now just got some labs:

Total Testosterone 10,65 ng/mL (2,21 – 7,16 ng/mL)
Free Testosterone 21,0 pg/mL (3,6 – 25,7 pg/mL)
DHT 625,7 pg/mL (143 – 842 pg/mL)
Estradiol (E2) 65,22 pg/mL (<62 pg/mL)
SHBG 16,7 nmol/L (13,5 – 71,4 nmol/L)

I didn'd expect such a high level of testosterone with HCG mono, especially after years struggling with HCG.
Estradiol high Level does not seem to be a problem at this moment.

 

Update: during the last month HCG Monotherapy dose (Ovitrelle) has being 790 IU M, W, F. with Anastrozole 0.25 mg M,W.F.
HCG has always been a nightmare for me regarding libido and ED. This time is completely different, I have great libido, and ED has improved dramatically, almost no need for PDE5i (only 25 mg sildenafil, before was 100 mg plus daily tadalafil). Now just got some labs:

Total Testosterone 10,65 ng/mL (2,21 – 7,16 ng/mL)
Free Testosterone 21,0 pg/mL (3,6 – 25,7 pg/mL)
DHT 625,7 pg/mL (143 – 842 pg/mL)
Estradiol (E2) 65,22 pg/mL (<62 pg/mL)
SHBG 16,7 nmol/L (13,5 – 71,4 nmol/L)

I didn'd expect such a high level of testosterone with HCG mono, especially after years struggling with HCG.
Estradiol high Level does not seem to be a problem at this moment.

That's good to know.
The last time I tried hCG mono was at a dose of 500 iu eod which achieved a TT of 27 nmol/L (778 ng/dL) 48 hours after my last dose.
Do you know approximately how high my level would have been 24 hours after my last dose?
I was using a compounded hCG which did not make me feel anywhere near as good as Pregnyl.
I was actually surprised to see that it had raised my testosterone so high because it did not increase libido and energy one bit, unlike Pregnyl.

 

Update: during the last month HCG Monotherapy dose (Ovitrelle) has being 790 IU M, W, F. with Anastrozole 0.25 mg M,W.F.
HCG has always been a nightmare for me regarding libido and ED. This time is completely different, I have great libido, and ED has improved dramatically, almost no need for PDE5i (only 25 mg sildenafil, before was 100 mg plus daily tadalafil). Now just got some labs:

Total Testosterone 10,65 ng/mL (2,21 – 7,16 ng/mL)
Free Testosterone 21,0 pg/mL (3,6 – 25,7 pg/mL)
DHT 625,7 pg/mL (143 – 842 pg/mL)
Estradiol (E2) 65,22 pg/mL (<62 pg/mL)
SHBG 16,7 nmol/L (13,5 – 71,4 nmol/L)

I didn'd expect such a high level of testosterone with HCG mono, especially after years struggling with HCG.
Estradiol high Level does not seem to be a problem at this moment.

You never even had the most critical blood marker free testosterone tested using an accurate assay the gold standard Equilibrium Dialysis.

Your FT was most likely tested using the known to be inaccurate direct immunoassay which should not be used/relied upon.

With a high TT 1065 ng/dl and lowish SHBG 16.7 nmol/L it is a given that your FT will be very high as in 30+ ng/dL.

Even then seeing as you live in Spain if you do not have access to Equilibrium Dialysis you can easily calculated your FT using the linear law-of-mass action Vermeulen (cFTV) which will give a good approximation.

If we plug in your high TT 1065 ng/dL, lowish SHBG 16.7 nmol/L and Albumin 4.3 g/dL (default) then your cFTV 34. 4 ng/dL is very high.

Free & Bioavailable Testosterone calculator

Glad to hear you are responding well to hCG mono especially when it comes to libido which many can tend to struggle with on testosterone therapy due to that more T is better mentality pushed by all those brainwashed sheep let alone many can struggle on hCG mono!

Hopefully you maintain it long-term!

 

You never even had the most critical blood marker free testosterone tested using an accurate assay the gold standard Equilibrium Dialysis.

Your FT was most likely tested using the known to be inaccurate direct immunoassay which should not be used/relied upon.

With a high TT 1065 ng/dl and lowish SHBG 16.7 nmol/L it is a given that your FT will be very high as in 30+ ng/dL.

Even then seeing as you live in Spain if you do not have access to Equilibrium Dialysis you can easily calculated your FT using the linear law-of-mass action Vermeulen (cFTV) which will give a good approximation.

If we plug in your high TT 1065 ng/dL, lowish SHBG 16.7 nmol/L and Albumin 4.3 g/dL (default) then your cFTV 34. 4 ng/dL is very high.

Free & Bioavailable Testosterone calculator

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Glad to hear you are responding well to hCG mono especially when it comes to libido which many can tend to struggle with on testosterone therapy due to that more T is better mentality pushed by all those brainwashed sheep let alone many can struggle on hCG mono!

Hopefully you maintain it long-term!

hi, @madman ,
Thank you for your evaluation. The truth is, I don't have access to more accurate tests. What I value most are the symptoms and how I feel. I used to have problems with HCG (I don't have problems while on testosterone alone), but not this time. I'm still waiting to see how long this good respond to HCG will last; hopefully, it's long-term.

One thing is getting worse: my hypospermia, which is now less than 1 ml. Perhaps it's due to a high E2 level. It bothers me because I'm trying to get my wife pregnant. It's keeping me depressed.

Do you think my current hormonal profile contributes to the hypospermia?

 

Do you know approximately how high my level would have been 24 hours after my last dose?

My blood sample was taken on Friday morning before the corresponding HCG dose for that day and 48 hours after the previous dose.
I think the only way you have to know your level 24 hous later is testing it.