Having trouble fighting off depression ~8 weeks in, suggestions?

Funny you say that, my TSH has been climbing and just came back at 3.25. I know the new threshold is 3 and Defy likes it under 2.5 I believe. Asked them to order a full panel earlier today.

Since posting this thread, I’ve been feeling better overall but this weird random anxiety thing has been appearing, as have some other mood issues, weight gain, and fatigue. Sleep quality is not great

Any personal experience with this one by chance?
 
Is your life stressful? Was it stressful before you started? Dr. Mariano would often post that those with HPA dysregulation can actually feel worse on TRT. That is why he always treated HPA first, then Thyroid, then Testosterone. I also felt worse when I first started TRT and needed to get on Hydrocortisone to help get my HPA in order. I still take HC in the morning and would have been able to tolerate TRT without it. Not saying this is your issue, but sharing my experience.
 
Look around TIREDTHYROID.COM . Some good basic info. It is not uncommon to have someone that is hypothyroid be missed and get pushed onto antidepressants, when all that was needed was to get their thyroid ranges in the optimal levels.
A WORLD of difference being WITHIN RANGE and being OPTIMAL. I do not think that is taught in med school. That site will also list the basic labs, both thyroid, iron, etc. that SHOULD be ran to get a clear picture.
There are few other great sites but this one is easy to navigate through and provides a wealth of basic info as a starting point.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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