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  1. Pacman

    What is the reason that nandrolone causes depression? (Mechanism of action)

    Nandrolone is literally the only thing (so far) that helps me manage shoulder pain due to my cervical radiculopathy. But even at low doses (~60 mg a week), I seem to get very depressed on it, and feel "flatlined" about life in general. Good news is that even at 60 mg it helps immensely. I've...
  2. E

    MIF-1 (and other peptides) for Anhedonia/Depression

    Thought I would start a discussion about this awesome lesser known peptide, yet one of the peptides with quite a few actual human studies behind it. So I'll start with my experience before getting to the science: I have done a few cycles (they last 5-7 days of 8-10 mg) of it this year and...
  3. K

    Depression while on TRT

    I have been treating with multiple medications for depression for the past 4 years. I began TRT 18months ago after having my prostate removed due to cancer. in reading in this forum, I see that most men report their motivation and sense of well being improve while on TRT. Although THT has...
  4. Z

    DHT really low- makes no sense

    So I have been feeling pretty crappy lately (down depressed anxious and no libido) and decided to do labs. I had labs done and my t was -1319 E2 sensitive was - 31 Shgb- 42 Free T was 29 But the weirdest one was my dht it came in at 50pg/ml. Which is incredibly low. What makes no sense is I’m on...
  5. G

    Started TRT journey - five weeks in

    Good evening, everyone. I figured I'd make a thread documenting my progress. Hopefully the information and ensuing discussions contained herein could provide assistance for others down the line, as others' threads had provided for me. I also have some questions which will be added at the end, so...
  6. FunkOdyssey

    The Case Against Antidepressants

    I decided to create a new thread to compile some of the evidence against the use of antidepressant drugs to treat depression. In my mind, the most compelling reason to avoid them is that they may worsen the condition over time, so we will begin there. The following paper suggests poor-long...
  7. Pacman

    Does nandrolone contribute to (or cause) depression?

    I added nandrolone officially to my regimen about one month ago (I have tried it in the past but never very long). The purpose of adding it was to assist in resolving joint pain, and it works PERFECT!! 10 out 10, joint pain is nearly non-existent! I am doing physical therapy in addition...
  8. T

    The serotonin theory of depression: a systematic umbrella review of the evidence (20 July 2022)

    It is often assumed that the effects of antidepressants demonstrate that depression must be at least partially caused by a brain-based chemical abnormality, and that the apparent efficacy of SSRIs shows that serotonin is implicated. Other explanations for the effects of antidepressants have been...
  9. Vince

    New Drug Could Help Stop Depression, Anxiety, Brain Injury, and Cognitive Disorders

    A new preclinical drug reported by James Bibb, Ph.D., and colleagues has the potential to combat depression, brain injury, and cognitive disorders. The drug, which is notable for being brain-permeable, works by inhibiting the kinase enzyme Cdk5. Cdk5 is an important signaling regulator in...
  10. T

    Persisting ED and depression post Boldenone/Primo use

    I’ve spent the better part of the last 2 years struggling with persisting ED, Depression, Anhedonia following the use of Boldenone and then Primobolan. My symptoms align mostly with what a lot of people with PFS have but given I’ve never had PFS I’m reluctant to post on the propeciahelp forums...
  11. G

    Cabergoline and Depression

    I was reading that cabergoline increases dopamine so it can be used to treat depression. My brother's doctor prescribed him 0.25mg per week. What do you think ?
  12. M

    Would defy prescribe me parnate?

    For years I have dealt with treatment resistant depression. TRT has helped a bit, but it’s no magic bullet. I’ve been reading up on a medication called Parnate. It’s an MAOI and is apparently very successful at treating TRD. The only issue is mainstream doctors are hesitant to prescribe it, so...
  13. B

    Wellbutrin and TRT.

    Just curious if anyone felt/had symptoms of depression after starting TRT? I am 10 years in on TRT and I have felt mentally tired and unmotivated most of the entire time... I sometimes thought it was High E or low Thyroid but no matter how much I lowered E or adjusted thyroid (Armour) it...
  14. G

    Depression related to sun light

    I have noticed over the years like clock work a distinct drop in my mood (mildly depressed) on days where the sun is not out. I am more of one of the just “deal with it” guys and chalked it up to being normal but the positive effects sunlight has on my mood are too noticeable to ignore. I...
  15. Nelson Vergel

    Nitrous Oxide: Low dose of laughing gas can help patients with major depression

    "A previous study showed that laughing gas improved depression symptoms one day after treatment. In the new study, the researchers wanted to see whether those effects were long-lasting and whether a lower dose could work as well. To do this, they recruited 24 patients with TRMD, who were...
  16. J

    Depression and feeling poor after masturbation but not after sex

    All, I have friend who states that after orgasm from masturbation, will feel depressed, crappy, etc, but doesn't after orgasm during intercourse. He also asks about his refractory period. He states : "Vulnerable question -- does anybody else have a pretty severe refractory period? If so, have...
  17. T

    Anxiety and Depression increased since starting TRT

    I am on my 4th week of TRT. My testosterone was at 265 from a GP lab. Started at 150, 50 3/week. I was having high anxiety on injection day so this week I started 30 EOD. My anxiety and depression is worse than when I started. I am now second guessing using TRT. Should I continue and get labs in...
  18. T

    High rT3, low T3 and depression: study "Patients with thyroid disorders are more prone to develop depressive symptoms and conversely depression may be accompanied by various subtle thyroid abnormalities. Traditionally, the most commonly documented abnormalities are elevated T4...
  19. T

    Anybody using antidepressants with TRT? Similar to tramadol?

    I found that tramadol has a profound effect on my mood. It works by increasing serotonin, norepinephrine as well as working on one type of opioid receptor. Does anybody know of a similar AD?
  20. W

    Iodine and Thyroid

    This happened years ago and again in the last couple of weeks, so may be helpful for some. Various times in my life I have had depression and even after getting hormones tuned up there has been some nagging mild depression that creeps up. My T4 and T3 levels look good, but my TSH has sometimes...
  21. E

    Complete apathy/depression from too high E2?

    I started TRT 5 weeks ago on 24mg/day subcutaneous injections of Test C (168mg/week). My doc put me on a relatively high dose because my SHBG is very high (maybe 2-3 standard deviations out of range), so much so that despite having naturally high TT levels, my FT was in the dumpster all the way...
  22. N

    Depression and anxiety on TRT week 5 after great start.

    I've been on TRT for almost 5 weeks (started the 5th week last monday). I didn't feel much during the first 3 weeks, but at the beginning of the 4th week I started feeling much better. Very focused and clear of mind in a way I'd never experienced before. I've had brain fog my entire life and...
  23. M

    4 weeks into TRT, feeling worse/mood crashes.

    Hey folks, I’ve been on 100mg Test-C 1x/wk for 4 weeks now. For the first 2-3 weeks I was feeling great overall, sense of wellbeing was way up, energetic, more motivated in the gym... just really doing well. The last couple of days have been... not that. I take my Test-C Thursday evening or...
  24. S

    New User, Looking for advice, Questions about HCG, Thyroid, DHEA, etc.

    At age 33, After years of depression, anxiety, fatigue, weight gain, sleep problems, ed, etc. I convinced my doctor to test my hormones. I was specifically interested in my Cortisol levels due to prolonged profound amounts of physical anxiety. The results of what he tested were; Total...
  25. A

    Feeling emotionally flat?

    Taking my e2 from 72 to 11 and switching to Ed injections has done wonders for my anxiety panic attacks, I no longer feel anxious or emotional! I still have a dead sex drive? should I keep increasing my dose to see where I feel best at(been on this protocol for almost 6 weeks) I wanna see how...
  26. A

    E2 in range no drive!

    The doctor put me on .5 mg of armidex Ed and my e2 went from 72 to 11 on a sensitive test! Range (8-28) my sex drive is still zero! I’m on daily prop injections of 15 mg Ed! someone recommended raising the dose to 175 mg should I?
  27. D

    Nandrolone (Deca Durabolin): Effect on Lab Tests

    PARTICIPATION NEEDED! Of those EM members that have taken nandrolone or are currently taking nandrolone alongside their TRT, we are conducting a small ExcelMale study to help determine the effect that nandrolone has on Total Testosterone, E2, Prolactin, SHBG, free T, and DHT while taking TRT...
  28. A

    Thinking about taking my life because of ED!

    I am really fed up with life! I haven’t masturbated in almost 12 months! My libido is non existence my brain is foggy my dick is numb!my anxiety is that of a womanI keep reading about how some people never get there sex drive back on trt! It’s over for me! I’ve taking three doses of .5 armidex...
  29. A

    When should ai start working?

    Took two doses of .5 Adex day after t shot and not feeling much! On 62.5 e3d, I did a tren test cycle before someone told me my prolactin can still be elevated have the opportunity to get some caber should I add it?
  30. A

    Is Marriage for Me? Seeking input from guys.

    Hey guys thanks for looking at my post. I have a fiance and shes amazing and wonderful and I love her to death the problem is I am dreading marriage life and feel like my life is over. I don't sleep with her that well. She falls asleep very easily unlike myself and I dread once having kids...
  31. A

    Extremely high e2?

    Just got my bloodwork had Ed for months! My e2 sensitive came back at 72! What would a good ai dose be? Have Arimidex on deck! On 125 mg of test!
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