Gene's Nitric Oxide Stack

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)

Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)

More Than a Muscle Pump: The Surprising Science of the Nitric Oxide Stack​

In the biohacking world, we often chase complex peptides or experimental compounds, but we frequently overlook the most fundamental currency of life: blood flow. In the quest for longevity, systemic vascular efficiency is the baseline upon which all other health markers are built. As we age, our ability to maintain vasodilatory capacity diminishes, impacting everything from cognitive sharpness to metabolic health. "Gene’s Nitric Oxide Stack," a protocol born and refined within the ExcelMale community, has emerged as a definitive solution for men seeking to optimize this system. This isn't just a gym supplement routine; it is a sophisticated approach to anti-aging that leverages amino acids and targeted pharmaceutical interventions to restore the body’s most vital delivery mechanism.

Beyond the Mirror: The Science of the Sustained Pump​

For the average gym-goer, the "pump" is a transient aesthetic goal—a fleeting moment of muscle fullness. However, for a longevity specialist, a "harder pump" and increased vascularity are indicators of high-functioning endothelial health. The Nitric Oxide Stack is engineered to produce a state of vasodilation that doesn't simply vanish when you rack the weights.

By optimizing the nitric oxide signaling pathway, this protocol facilitates a sustained pump that carries through your daily life. This is a critical distinction: the visual vascularity is a proxy for your body’s ability to keep its "pipes" open. When you maintain that fullness hours after a workout, you are essentially providing proof of concept that your circulatory system is operating at peak efficiency, ensuring constant nutrient delivery to peripheral tissues.

The Foundation of Performance: Hard Science for Sexual Vitality​

One of the most immediate benefits of systemic vasodilation is the restoration of sexual function. From a clinical perspective, erection quality is often the "canary in the coal mine" for cardiovascular health. Because the Nitric Oxide Stack focuses on the root physiological requirements of performance—blood flow and retention—it provides a robust alternative to temporary fixes.

A Serious Solution for Erection Quality and Duration

This stack addresses both the quality and the duration of erections with clinical precision. For men navigating the aging process, this is not a matter of vanity, but of maintaining vital physiological function. By ensuring the vascular system can respond effectively to neurological signals, the protocol allows for a level of performance that many mistakenly believe is lost to time.

The Ultimate Nootropic: Future-Proofing the Neocortex​

Perhaps the most compelling argument for nitric oxide optimization is the "bodybuilder to brain health" pipeline. While most men start this stack for its physical benefits, they are unknowingly deploying a powerful shield against age-related cognitive decline. As we age, the micro-vasculature within the brain tends to narrow and tighten, a process that starves the brain of oxygen and is a primary driver of age-related dementia.

The stack acts as a nootropic by ensuring that the brain's smallest vessels remain dilated and resilient. This ensures that the neocortex and other critical regions receive a constant supply of the nutrients required for cognitive longevity. As the source material highlights:

"by increasing nitric oxide and getting that vascular dilation we're getting oxygen blood and nutrients in the areas of the brain that can provide us with a great anti-aging benefit in terms of neurological health."

The irony is profound: a protocol often associated with the bicep curl may actually be one of your most effective tools for protecting your mind.

Systemic Management: Blood Pressure and Prostate Function​

The benefits of the stack extend into the deeper mechanics of men’s health, specifically regarding the relaxation of smooth muscle tissue. This is particularly relevant for Benign Prostate Hyperplasia (BPH) and blood pressure management. Nitric oxide serves as a signal for these tissues to relax, directly easing the "inability to ease the problems" that typically characterize age-related prostate issues.

The secondary physiological advantages of this systemic relaxation include:

• Vascular Tension Reduction: Significant support for maintaining healthy blood pressure levels by reducing resistance within the arterial walls.
• Prostate Relief: Improvement in quality of life by relaxing the prostatic smooth muscle, easing the mechanical symptoms of BPH.
• Reduced Cardiac Load: By improving systemic flow, the heart is not required to pump against the same level of resistance, preserving cardiovascular longevity.

The Future of Your Vascular Health​

"Gene’s Nitric Oxide Stack" is far from a theoretical exercise; it is a "living protocol" backed by years of community peer-review within the ExcelMale community. The "enormously long" and widely viewed thread on ExcelMale.com serves as a testament to the real-world efficacy of this stack, offering a repository of shared experiences and optimization strategies.

This multi-front approach to anti-aging represents the best of biohacking: using fundamental biological pathways to solve complex aging problems. By focusing on the delivery system itself, we can protect our brains, our hearts, and our vitality simultaneously.

If blood flow is the delivery system for every nutrient your body needs, what happens to your longevity when you finally optimize that system?


More on Nitric Oxide in Men:

Nitric Oxide Pages

 

First off, I have been weight-training for 30 years and have taken every supplement and tried every diet, except steroids/TRT. At 47, I am in the best shape of my life and have been on Gene's stack for almost 3 years straight! As long as you don't get side effects to the CIALIS there are so many reasons to take it. I just saw some solid research on pairing PDE5 inhibitors with EGCG and that prevents cancer. Its great for BPH/prostate issues also. Pairing it with the rest of the stack makes me feel great! My question is, has anyone taken curcumin with Cialis? I want to take it for the health benefits but see that its not recommended to take with any drug that relies on CYP3A4 which Cialis does. Any thoughts? Anyone taking Gene's stack 3+ years yet like me?

What side effects of Cialis are you referring to specifically?

 

First off, I have been weight-training for 30 years and have taken every supplement and tried every diet, except steroids/TRT. At 47, I am in the best shape of my life and have been on Gene's stack for almost 3 years straight! As long as you don't get side effects to the CIALIS there are so many reasons to take it. I just saw some solid research on pairing PDE5 inhibitors with EGCG and that prevents cancer. Its great for BPH/prostate issues also. Pairing it with the rest of the stack makes me feel great! My question is, has anyone taken curcumin with Cialis? I want to take it for the health benefits but see that its not recommended to take with any drug that relies on CYP3A4 which Cialis does. Any thoughts? Anyone taking Gene's stack 3+ years yet like me?

Interesting, what issue would one theoretically have if taking Cialis and Curcumin. I've done so without any issues, as far as I know. I don't take cialis daily though.

 

What side effects of Cialis are you referring to specifically?

I got a friend that gets a crazy back ache and other muscle pains when he takes CIALIS. I occasionally notice stuffy nose. Both are common side effects of it. Stuffy nose is bearable for me but he had to stop from the back aches and muscle pain

 

your liver processes CIALIS with the CYTOCHROME P450 enzyme CYP3A4. If another drug or supplement affects this enzyme that will either speed up or slow down the processing of the CIALIS. If it slows down the processing, their is a potential to have too much CIALIS build-up in your body. I always google the supplement I am taking to see if it affects the CYP3A4 enzyme that your liver uses to process CIALIS.

 

I got a friend that gets a crazy back ache and other muscle pains when he takes CIALIS. I occasionally notice stuffy nose. Both are common side effects of it. Stuffy nose is bearable for me but he had to stop from the back aches and muscle pain

Do the back/leg/joint aches go away if you keep taking it?

 

The liquid cia/ citrulline / arginine / hgw / pycno / dhea routine worked for a few months when I first started but now is not reliable. Is anyone using Trimix with any good results? It looks like this is my doctor only at a quick search but if anyone has suggestions that would be great.

 

So why has Arginine Ethyl Ester been discontinued and off the shelf? Anyone still taking it?

I was wondering that too.. It seems arginine ethyl ester has been discontinued on most sites including Amazon.
Is anyone still taking arginine ethyl ester and if you are where do you get it. Is there a reason it has become mostly not available?

 

I was wondering that too.. It seems arginine ethyl ester has been discontinued on most sites including Amazon.
Is anyone still taking arginine ethyl ester and if you are where do you get it. Is there a reason it has become mostly not available?

I just copy and paste arginine ethyl ester and it's still on amazon. Personally I haven't used it for a long time.

 

The liquid cia/ citrulline / arginine / hgw / pycno / dhea routine worked for a few months when I first started but now is not reliable. Is anyone using Trimix with any good results? It looks like this is my doctor only at a quick search but if anyone has suggestions that would be great.

Have you tried real Cialis? Most of the research chems could be pretty spotty, they were when I dabbled with them, I now buy from overseas with better results. If you want to talk about TriMix we have some great threads on that if you look around a little bit.

 

Have you tried real Cialis? Most of the research chems could be pretty spotty, they were when I dabbled with them, I now buy from overseas with better results. If you want to talk about TriMix we have some great threads on that if you look around a little bit.

Agree with Vince. I use ADC for cialis and splitting costs about the same. Arginine and citruline are inexpensive as well, at least for the results you get. I have thought about trimix but why do that before all other things have been exhausted? While errections of 2 hours sounds very appealing to me, my wife disagrees. She is satisfied with 20 to 30 minutes. Any longer and she gets too sore and needs more than 2 days for that to change. I wouldn’t jump to the nuclear solution too soon...

 

I use liquid cia. Early on wia g the stack bit was great. Now not so good. Real cia 2x20mg tabs don’t insure a reliable erection and definitely not of any good duration. I did tests once with a uriglogist 10+ years ago and whatever injection he used was a lower dose but immediate results. I’ll look at those threads on Trimix. Thanks

 

I am on the same stack for the most part. I do modify the dosage of the Tadalafil sometimes as it's the foundation of this stacks success.

I will take this to the day I die; it's health benefits abound as an anti-aging protocol besides what it does for bodybuilding...which is impressive in and of its self!

BTW, want to increase the effects of the tadalafil? Try taking it with grapefruit juice and see what happens;-)

One Question, In a previous post you said you started to take Arginine Ethyl Ester to replace both Arginine and Citrulline. Is that still the case or have you went back to the original Arginine and Citrulline ? Thank You! Your expertice is always appreciated.

 

I just finished a second bottle of arginine ethyl ester and I can feel no difference whatsoever between it and "regular' arginine even after using it at double or triple the recommended dosage. No big pumps like some guys get from it, sadly. I had really wanted this to work.

 

I just finished a second bottle of arginine ethyl ester and I can feel no difference whatsoever between it and "regular' arginine even after using it at double or triple the recommended dosage. No big pumps like some guys get from it, sadly. I had really wanted this to work.

Also, in a previous post Agmatine was briefly mentioned. Does anyone use Agmatine, and if you do, when and how do you take it ? There seems to be little to no research on this supplement.

 

I liked Agmatine when I used it, I think it's something though you have to take it on an empty stomach though, there was something like that about it and carbs countering but you'll have to google and research that.

 

I have used Agmatine, but for it to do anything you MUST take it alone - mixing it with Arginine or Citruline nullifies its effect. It seemed to work well for me at first and then not so much after a couple of weeks.

 

ya that's it you have to take it alone on an empty stomach, no Arg or Citrulline either.

 

Hi Gene,

Thank you very much for your recommendation. I most definitely will give it a try, meanwhile I was wondering if you could please let know for how long you take the NO stack for and whether you have any resting periods at all?

Thank you very much in advance.

Antonio

 

In past posts Garlic/Vitamin C and Beet Juice have been mentioned in addition to the original stack. In your opinions do these additions make a differance or are they overkill ? I appreciate your opinions.

 

Has anyone tried Tri-Amino or similar injectable L-Arginine and L-Citrulline? Did you noticed significant benefits compared to powder or pills? http://defymedical.com/services/68-tri-amino-oac-injection-therapy