Gene's Nitric Oxide Stack

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)


nitric oxide excelmale.webp

Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)



More Than a Muscle Pump: The Surprising Science of the Nitric Oxide Stack

In the biohacking world, we often chase complex peptides or experimental compounds, but we frequently overlook the most fundamental currency of life: blood flow. In the quest for longevity, systemic vascular efficiency is the baseline upon which all other health markers are built. As we age, our ability to maintain vasodilatory capacity diminishes, impacting everything from cognitive sharpness to metabolic health. "Gene’s Nitric Oxide Stack," a protocol born and refined within the ExcelMale community, has emerged as a definitive solution for men seeking to optimize this system. This isn't just a gym supplement routine; it is a sophisticated approach to anti-aging that leverages amino acids and targeted pharmaceutical interventions to restore the body’s most vital delivery mechanism.

Beyond the Mirror: The Science of the Sustained Pump​

For the average gym-goer, the "pump" is a transient aesthetic goal—a fleeting moment of muscle fullness. However, for a longevity specialist, a "harder pump" and increased vascularity are indicators of high-functioning endothelial health. The Nitric Oxide Stack is engineered to produce a state of vasodilation that doesn't simply vanish when you rack the weights.

By optimizing the nitric oxide signaling pathway, this protocol facilitates a sustained pump that carries through your daily life. This is a critical distinction: the visual vascularity is a proxy for your body’s ability to keep its "pipes" open. When you maintain that fullness hours after a workout, you are essentially providing proof of concept that your circulatory system is operating at peak efficiency, ensuring constant nutrient delivery to peripheral tissues.

The Foundation of Performance: Hard Science for Sexual Vitality​

One of the most immediate benefits of systemic vasodilation is the restoration of sexual function. From a clinical perspective, erection quality is often the "canary in the coal mine" for cardiovascular health. Because the Nitric Oxide Stack focuses on the root physiological requirements of performance—blood flow and retention—it provides a robust alternative to temporary fixes.

A Serious Solution for Erection Quality and Duration

This stack addresses both the quality and the duration of erections with clinical precision. For men navigating the aging process, this is not a matter of vanity, but of maintaining vital physiological function. By ensuring the vascular system can respond effectively to neurological signals, the protocol allows for a level of performance that many mistakenly believe is lost to time.

The Ultimate Nootropic: Future-Proofing the Neocortex​

Perhaps the most compelling argument for nitric oxide optimization is the "bodybuilder to brain health" pipeline. While most men start this stack for its physical benefits, they are unknowingly deploying a powerful shield against age-related cognitive decline. As we age, the micro-vasculature within the brain tends to narrow and tighten, a process that starves the brain of oxygen and is a primary driver of age-related dementia.

The stack acts as a nootropic by ensuring that the brain's smallest vessels remain dilated and resilient. This ensures that the neocortex and other critical regions receive a constant supply of the nutrients required for cognitive longevity. As the source material highlights:

"by increasing nitric oxide and getting that vascular dilation we're getting oxygen blood and nutrients in the areas of the brain that can provide us with a great anti-aging benefit in terms of neurological health."

The irony is profound: a protocol often associated with the bicep curl may actually be one of your most effective tools for protecting your mind.

Systemic Management: Blood Pressure and Prostate Function​

The benefits of the stack extend into the deeper mechanics of men’s health, specifically regarding the relaxation of smooth muscle tissue. This is particularly relevant for Benign Prostate Hyperplasia (BPH) and blood pressure management. Nitric oxide serves as a signal for these tissues to relax, directly easing the "inability to ease the problems" that typically characterize age-related prostate issues.

The secondary physiological advantages of this systemic relaxation include:

  • Vascular Tension Reduction: Significant support for maintaining healthy blood pressure levels by reducing resistance within the arterial walls.
  • Prostate Relief: Improvement in quality of life by relaxing the prostatic smooth muscle, easing the mechanical symptoms of BPH.
  • Reduced Cardiac Load: By improving systemic flow, the heart is not required to pump against the same level of resistance, preserving cardiovascular longevity.

The Future of Your Vascular Health​

"Gene’s Nitric Oxide Stack" is far from a theoretical exercise; it is a "living protocol" backed by years of community peer-review within the ExcelMale community. The "enormously long" and widely viewed thread on ExcelMale.com serves as a testament to the real-world efficacy of this stack, offering a repository of shared experiences and optimization strategies.

This multi-front approach to anti-aging represents the best of biohacking: using fundamental biological pathways to solve complex aging problems. By focusing on the delivery system itself, we can protect our brains, our hearts, and our vitality simultaneously.

If blood flow is the delivery system for every nutrient your body needs, what happens to your longevity when you finally optimize that system?


More on Nitric Oxide in Men:

Nitric Oxide Pages
 
Last edited by a moderator:
The prices look a little high, have you tried ordering from that site? I wonder if it's the original secure tab.
I have used this site twice with good results. I payed $0.93 each for 5mg (360tabs). Shipping takes about 2 weeks.
Vince are you saying you can get it cheaper?
 
To those guys using Gene's Stack with little to no changes to the dosing I have a couple questing if I may.

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)



Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)

1) how long before you saw or felt changes when using this stack?
2) Are you a body builder or weight lifter?
3) Bedroom improvements? Weightroom improvements?

I ask because I have been on this stack for about 5 weeks. First week was half dose to be cautious.
I am not seeing or feeling much in the gym or bedroom and I have not altered the doses.
That said I do see a little improvement in both areas. But you have to really look. Libido is unchanged but erections are a bit stronger.

There are some major differences between me and Gene. I am 15 years older than him.
I am not a bodybuilder but I do go to a gym 4 days a week and I ride a mtn bike 14-20 miles 3 times a week year round.
I am 64 years old, height 5'9", weight 192#, body fat 13%

pre stack starting pict:
23773438738_122366c29b_n.jpg


5 weeks in:
38418668621_8e9d61f46d.jpg


I plan to continue the stack for the next couple months. At 64 nothing happens overnight.

I just did a blood draw on Monday for my 2nd TRT protocol adjustment looking forward to that report in 2 weeks.

EDIT: OK I think I found my answer all the way back on post #41
 
Last edited:
I've been reading through this thread the past couple days, and have decided to give this a shot. I am 36, 205lbs 14-15% BF and go to the gym 5-6 days a week. My TRT protocol is .35mL of T with 500iu of HCG E3.5D. I also take 50mg of DHEA and 1750mg of metformin daily, along with multi-vitamins, krill oil, ZMA, etc.


My main concern with this stack is the Doxazosin. I have always had normal blood pressure, and wonder if this may cause me to feel weak/dizzy. My current BP reading averages 100/62. How necessary is the Doxazosin in this stack? I ordered some just in case, but wanted to get others opinions on this.

Also, I noticed that through reliablerx it would save me more money if I get 10mg tablets and cut them in half. For example, they sell 80 10mg tablets for $90 or 80 5mg tablets for $60. So, $0.75 a piece for 5mg, or $0.56 a piece for the 10mg cut in half. Does cutting it in half reduce the potency? Or are these pills generally too small to cut in half?

Thanks for the help!
 
A heads up incase you did not know Loki Doxazosin (Cardura) is an alpha blockers used to treat high blood pressure. I don't have blood pressure issues and my pressure dropped 10 points on the top and bottom(109/58) for several days making me feel weak lethargic with no endurance. I also had one day where my resting heart rate went from 61 to 76 for 24 hours.
So keep an eye on yours for that first week. I'm 3 full weeks in now and just starting to see and feel this stack. All negative sides have gone.

You're body is just adjusting and is normal for some men.

My BP and resting heart rate is text book with this stack...it's amazing.
 
Nice to hear someone taking the Horny Goat Weed daily with no breaks because I plan on doing the same and most of what I see online says to cycle it.....Regarding the Tadalafil are you using a liquid or pill form? If liquid are you allowed to share who? (if that's frowned upon here sorry just curious) The one I am using is solid for now but these liquid company's can be hit or miss sometimes so if the quality ever goes down with mine its nice to have a back up......and when you say modify dosage how so? Ive never heard of the grapefruit juice but ill take a look.....*Edit - It seems like grapefruit juice with Tadalafil can enhance results but also be dangerous so ill most likely leave that alone.

I get my liquid Cia from the RC sites. I like rui-products and BlueSky as both have been very consistent and cheap.

You can also get them overseas as well as the Doxizosin from https://www.reliablerxpharmacy.com/catalogsearch/result/?q=Tadalafil
 
You're body is just adjusting and is normal for some men.

My BP and resting heart rate is text book with this stack...it's amazing.

I think the question is: What if you have text book BP and resting heart rate already without an alpha blocker? Should you still keep an alpha blocker in your stack?
 
I think the question is: What if you have text book BP and resting heart rate already without an alpha blocker? Should you still keep an alpha blocker in your stack?

The answer is; of course. But the Dox is at a very very low dose here compared to the prescription strength of 4 to 6 mg daily where low BP is more prominent.
 
I get my liquid Cia from the RC sites. I like rui-products and BlueSky as both have been very consistent and cheap.

You can also get them overseas as well as the Doxizosin from https://www.reliablerxpharmacy.com/catalogsearch/result/?q=Tadalafil

Thanks, currently using Maxim and there Tadalafil seems like the best out of the couple others I have tried.... I will keep Blue Sky in mind if I feel Maxims quality ever goes to down or I want to give another brand a shot to compare, I currently have 3 bottles so hopefully ordering in bulk doesn't effect the quality if it sits for a few months.....I used RUI many years ago for other stuff when I was on gear (which I don't use anymore) but last time I checked the prices were a little high and they were not taking credit cards.
 
Has anyone used Icariin without issues while using Lisinopril? I’m prescribed 5 mg of Lisinopril, but would like to add the horny goat weed to a version of my stack (not using dox)
 
Anyone have a good source for in stock Doxazsin, that ships fairly quick? My regular sources (reliablerx, etc) all seem to be out of stock, and I have all the other components for this stack. Any help would be appreciated!
 
The answer is; of course. But the Dox is at a very very low dose here compared to the prescription strength of 4 to 6 mg daily where low BP is more prominent.

Gene is on point here, the DOx dosage of 1mg is well below what is typically prescribed for BP. Dox really acts as a smooth muscle relaxant = more blood flow.
 
I did have issues with taking 1mg morning and 1mg evenings. Enough so that I only too 1 mg in the evening for 7 days.
Here's some snapshots of what I am monitoring. Sorry for you taptalk phone guys this pict is a biggy.

37835321862_b6f5f2cf79_b.jpg


The 109 blood pressure was on day two of 2mg and the resting HR of 76 was day 3.
After that everything seemed to smooth out and I have been on the full NO stack for about 7 weeks.

At the gym I have noticed a bit more vascularity but I lose it pretty quick. I am still trying to build muscle while recovering from Sarcopenia
its not like I'm a 20 something and it hasn't helped that my protocol for the last 6 months had my TT between 300-350 and FT 11-12. ;-(
 
First off, I have been weight-training for 30 years and have taken every supplement and tried every diet, except steroids/TRT. At 47, I am in the best shape of my life and have been on Gene's stack for almost 3 years straight! As long as you don't get side effects to the CIALIS there are so many reasons to take it. I just saw some solid research on pairing PDE5 inhibitors with EGCG and that prevents cancer. Its great for BPH/prostate issues also. Pairing it with the rest of the stack makes me feel great! My question is, has anyone taken curcumin with Cialis? I want to take it for the health benefits but see that its not recommended to take with any drug that relies on CYP3A4 which Cialis does. Any thoughts? Anyone taking Gene's stack 3+ years yet like me?
 

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