Gene's Nitric Oxide Stack

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)


nitric oxide excelmale.webp

Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)



More Than a Muscle Pump: The Surprising Science of the Nitric Oxide Stack

In the biohacking world, we often chase complex peptides or experimental compounds, but we frequently overlook the most fundamental currency of life: blood flow. In the quest for longevity, systemic vascular efficiency is the baseline upon which all other health markers are built. As we age, our ability to maintain vasodilatory capacity diminishes, impacting everything from cognitive sharpness to metabolic health. "Gene’s Nitric Oxide Stack," a protocol born and refined within the ExcelMale community, has emerged as a definitive solution for men seeking to optimize this system. This isn't just a gym supplement routine; it is a sophisticated approach to anti-aging that leverages amino acids and targeted pharmaceutical interventions to restore the body’s most vital delivery mechanism.

Beyond the Mirror: The Science of the Sustained Pump​

For the average gym-goer, the "pump" is a transient aesthetic goal—a fleeting moment of muscle fullness. However, for a longevity specialist, a "harder pump" and increased vascularity are indicators of high-functioning endothelial health. The Nitric Oxide Stack is engineered to produce a state of vasodilation that doesn't simply vanish when you rack the weights.

By optimizing the nitric oxide signaling pathway, this protocol facilitates a sustained pump that carries through your daily life. This is a critical distinction: the visual vascularity is a proxy for your body’s ability to keep its "pipes" open. When you maintain that fullness hours after a workout, you are essentially providing proof of concept that your circulatory system is operating at peak efficiency, ensuring constant nutrient delivery to peripheral tissues.

The Foundation of Performance: Hard Science for Sexual Vitality​

One of the most immediate benefits of systemic vasodilation is the restoration of sexual function. From a clinical perspective, erection quality is often the "canary in the coal mine" for cardiovascular health. Because the Nitric Oxide Stack focuses on the root physiological requirements of performance—blood flow and retention—it provides a robust alternative to temporary fixes.

A Serious Solution for Erection Quality and Duration

This stack addresses both the quality and the duration of erections with clinical precision. For men navigating the aging process, this is not a matter of vanity, but of maintaining vital physiological function. By ensuring the vascular system can respond effectively to neurological signals, the protocol allows for a level of performance that many mistakenly believe is lost to time.

The Ultimate Nootropic: Future-Proofing the Neocortex​

Perhaps the most compelling argument for nitric oxide optimization is the "bodybuilder to brain health" pipeline. While most men start this stack for its physical benefits, they are unknowingly deploying a powerful shield against age-related cognitive decline. As we age, the micro-vasculature within the brain tends to narrow and tighten, a process that starves the brain of oxygen and is a primary driver of age-related dementia.

The stack acts as a nootropic by ensuring that the brain's smallest vessels remain dilated and resilient. This ensures that the neocortex and other critical regions receive a constant supply of the nutrients required for cognitive longevity. As the source material highlights:

"by increasing nitric oxide and getting that vascular dilation we're getting oxygen blood and nutrients in the areas of the brain that can provide us with a great anti-aging benefit in terms of neurological health."

The irony is profound: a protocol often associated with the bicep curl may actually be one of your most effective tools for protecting your mind.

Systemic Management: Blood Pressure and Prostate Function​

The benefits of the stack extend into the deeper mechanics of men’s health, specifically regarding the relaxation of smooth muscle tissue. This is particularly relevant for Benign Prostate Hyperplasia (BPH) and blood pressure management. Nitric oxide serves as a signal for these tissues to relax, directly easing the "inability to ease the problems" that typically characterize age-related prostate issues.

The secondary physiological advantages of this systemic relaxation include:

  • Vascular Tension Reduction: Significant support for maintaining healthy blood pressure levels by reducing resistance within the arterial walls.
  • Prostate Relief: Improvement in quality of life by relaxing the prostatic smooth muscle, easing the mechanical symptoms of BPH.
  • Reduced Cardiac Load: By improving systemic flow, the heart is not required to pump against the same level of resistance, preserving cardiovascular longevity.

The Future of Your Vascular Health​

"Gene’s Nitric Oxide Stack" is far from a theoretical exercise; it is a "living protocol" backed by years of community peer-review within the ExcelMale community. The "enormously long" and widely viewed thread on ExcelMale.com serves as a testament to the real-world efficacy of this stack, offering a repository of shared experiences and optimization strategies.

This multi-front approach to anti-aging represents the best of biohacking: using fundamental biological pathways to solve complex aging problems. By focusing on the delivery system itself, we can protect our brains, our hearts, and our vitality simultaneously.

If blood flow is the delivery system for every nutrient your body needs, what happens to your longevity when you finally optimize that system?


More on Nitric Oxide in Men:

Nitric Oxide Pages
 
Last edited by a moderator:
I am currently on low dose Diltiazem 120 mg... would it be safe to add the 1mg Doxazosin in the nitric oxide stack ?
THANK YOU...
I may not have given a proper explanation. I am now on Diltiazem
(Calcium channel Blocker) for mild Tachycardia(fast heartbeat at rest)..
Would it be safe to also take the Doxazosin? (Alpha Blocker)
 
Last edited:
Probably asked before, but I've got a question about the safety of combining parts of this stack.
I get my protein from PES (absolutely delicious - I highly recommend the Peanut Butter Cup) and they sent me a sample of their "High Volume" Nitric Oxide supplement. It contains:

Vitamin C (250mg)
L-Citrulline (4,000mg)
"Performance Pump Matrix" (3750mg), which contains
- Taurine
- Gylcerol 65%
- Ferula Asafoetida extract
- Arginine Nitrate (2,000mg)
- Agmatine Sulfate (1,000mg)

The label contains the following warning:

Do not use if you are taking erectile dysfunction medication. Do not take additional nitrates in the form of medication or dietary supplements along with this product.

It does not explain why. Some of the ingredients are part of Gene's stack. I'm curious where and what the risk is. Is there some danger in combining citrulline and a PDE5 inhibitor? Agmatine? Arginine?

My urologist prescribed me 5mg daily Cialis, which I take about twice a week. I tried out the High Volume and felt pretty good, and got a few spontaneous erections - not sure if it was the cause. I heeded the advice on the label, though, and didn't combine it with the Cialis. If this is just boilerplate warning, I might buy some of the High Volume and mix take both Cialis and a scoop of it on the same day. If it's serious, I won't.

Ive had no problems with anything in the stack NO related like Citrulline or Arginine in combination with a PDE5, in fact they work quite well together, for me. I think some of the cautionary tales revolve around blood pressure getting low as they can all act together to lower BP, to an extent.
 
Ive had no problems with anything in the stack NO related like Citrulline or Arginine in combination with a PDE5, in fact they work quite well together, for me. I think some of the cautionary tales revolve around blood pressure getting low as they can all act together to lower BP, to an extent.


Thanks! I'll give it a shot.
 
I must say this has been a game changer for me!! In the gym and in the bedroom, almost every day I get a comment about the veins. I have learned to buy my supplies in quantity from pipingrock.com when they go on sale. I have used the other brands vitamin shop and such but the cost of buying in quantity from pipingrock is huge. I currently use the source naturals HGW bought from amazon is the best price I can find. I also use 90% Icarrin from lift mode in my smoothies....when I know I am going to be sexually active and I find it give me a boost in all areas including stamina. I have ordered the 60% from icariinhealth but I find this to be too costly and a pain to order sometimes as it is overseas and my cc company wants to decline the transaction. For the tadalafil I have been using blueskypeptides. I am on their email list and I get promo codes that allow up to 40 to 50% off so i buy bottles in quantity there as well and it is very cost effective, I have varied the doses and whether I consume 5mg or 15 mg I get the same effects so I stick with 5mg or about 5 drops (the side effects went away after about two weeks). I have a very big cardboard box full of bottles of most of the sup's in this stack. I have bought quantity of small plastic ziplock bags. I usually take a day every week or two, lay a towel out on the counter top start making piles and make up bags so they are ready to go when I need them.

Question: I am not using Doxazosin ...what difference will I see if I incorporate this into my stack? Has anyone added to something to this stack that has made a significant difference?

The upside to this is I am always ready to go but the downside my wife has a significantly lower libido than I do so it can be frustrating to say the least. I have always had a high libido/drive. My wife's has diminished as time has passed. "The age old dilemma for most men I guess". We are working on getting her set up with Defy. Blood tests are done, appt with Dr Saya next week:o I would imagine most of the sup's in this stack would help the female as well but is there something to add or take away for the female?

Question: Is there a stack similar to this one for women that anyone can recommend?

I'd like to thank Gene and everyone else who has contributed to this thread. I have shared it with many friends and it has changed their lives as well. Also...excelmale.com and it's admin's and conributors.

Question: Is there a similar forum to excelmale for women to learn about health and hormones?

Thanks.
 
I get bulk L-citrulline (pure) via Amazon for $30 per kilo/2.2 lbs. Seems to work fine.

If your blood pressure is on the low side, be careful taking both doxasozin and Cialis (or other PDE-5 inhibitor). My BP dropped to 87/54 with this combination. I believe it is safer if you stagger the two drugs (i.e., PDE-5 inhibitor taken 4 or more hours after the doxazosin), which is what I do now.

Per the FDA: Concomitant administration of CARDURA with a PDE-5 inhibitor can result in additive bloodpressure lowering effects and symptomatic hypotension; therefore, PDE-5 inhibitor therapyshould be initiated at the lowest dose in patients taking CARDURA.
 
back to icariins or Horny Goat weed....please recommend one for me. I see propritary "blends" that I don't like, some others with Saw Palmetto, a known androgen bloc or other low potency, 10% icariins. Thanks
 
I started the stack with only Argenine, citruline and pycnogenol. I saw an improvement in bloodflow and pumps in the gym. Veins started to show more in my arms and legs, erections improved. I was researching what HGW to use and found the source naturals. Almost immediately I started having very strong early morning wood and random mid day wood (at this point I was not using tadalifil). I tried the icariin 60 and saw no difference except for the cost. Went back to source naturals for the cost factor. I recently started the lift mode icariin in my protein shakes for extra stamina but found that it boosts my libido and helps with erections. The only thing is for the lift mode icariin you need to use a lot to see the effects and for that reason cost is an issue with me to use it everyday in the stack. Also the tablets work better for me being able to prep them and carry them in my pocket and down with a glass of water.
 
On Amazon that lift mode is OUTRAGEOUSLY expensive. I picked up some of the DoctorCare + 20% icariins/HGW to try it out. I know I've had this before and wasn't too impressed by it but a few other things for me are starting to click so will try it again.
 
NO Stack

I started the stack with only Argenine, citruline and pycnogenol. I saw an improvement in bloodflow and pumps in the gym. Veins started to show more in my arms and legs, erections improved. I was researching what HGW to use and found the source naturals. Almost immediately I started having very strong early morning wood and random mid day wood (at this point I was not using tadalifil).

My experience/regimen mirrors CRASH...........and I only used Doxasin initially until the supply ran out, I do not notice any difference.
I do use the powder Arginine in a glass of water, tastes like drinking metal, but it is very efficient and I have gotten used to it , just down the hatch !
 
On Amazon that lift mode is OUTRAGEOUSLY expensive. I picked up some of the DoctorCare + 20% icariins/HGW to try it out. I know I've had this before and wasn't too impressed by it but a few other things for me are starting to click so will try it again.

I just bought the 10g bag of 90% icariin from list mode. $57 shipped... looking ward to adding it to the stack
 
How does this product look ? scroll down

1010mg of L-citrulline.

lplus-01.png

L-arginine Plus® is based on a Nobel Prize winning medical breakthrough and the discovery of nitric oxide, which some consider the most important advancement in the fight to maintain your health!

Serving: 1 level scoop (12.7 g)
Servings Per Container: 30
[TABLE="class: tve_table tve_no_inner_border tve_table_plain tve_white, width: 474"]
[TR="class: tve_table_row"]
[TH="class: tve_table_cell"]Amount Per Serving
[/TH]
[TH="class: tve_table_cell"][/TH]
[TH="class: tve_table_cell"]
% DV
[/TH]
[/TR]
[TR="class: tve_table_row"]
[TD="class: tve_table_cell"]Calories 35
[/TD]
[TD="class: tve_table_cell"][/TD]
[TD="class: tve_table_cell"][/TD]
[/TR]
[TR="class: tve_table_row"]
[TD="class: tve_table_cell"]Total Carbohydrates
[/TD]
[TD="class: tve_table_cell"]
4g
[/TD]
[TD="class: tve_table_cell"]
1%*
[/TD]
[/TR]
[TR="class: tve_table_row"]
[TD="class: tve_table_cell"]Vitamin C
[/TD]
[TD="class: tve_table_cell"]
60mg
[/TD]
[TD="class: tve_table_cell"]
100%
[/TD]
[/TR]
[TR="class: tve_table_row"]
[TD="class: tve_table_cell, colspan: 1"]Vitamin D3
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
2500IU
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
625%
[/TD]
[/TR]
[TR="class: tve_table_row"]
[TD="class: tve_table_cell, colspan: 1"]Vitamin K
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
20mcg
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
25%
[/TD]
[/TR]
[TR="class: tve_table_row"]
[TD="class: tve_table_cell, colspan: 1"]Vitamin B6
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
2mg
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
100%
[/TD]
[/TR]
[TR="class: tve_table_row"]
[TD="class: tve_table_cell, colspan: 1"]Folate
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
400mcg
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
100%
[/TD]
[/TR]
[TR="class: tve_table_row"]
[TD="class: tve_table_cell, colspan: 1"]Vitamin B12
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
6mcg
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
100%
[/TD]
[/TR]
[TR="class: tve_table_row"]
[TD="class: tve_table_cell, colspan: 1"]Magnesium
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
20mg
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
5%
[/TD]
[/TR]
[TR="class: tve_table_row"]
[TD="class: tve_table_cell, colspan: 1"]L-Arginine
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
5110mg
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
**
[/TD]
[/TR]
[TR="class: tve_table_row"]
[TD="class: tve_table_cell, colspan: 1"]L-Citrulline
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
1010mg
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
**
[/TD]
[/TR]
[TR="class: tve_table_row"]
[TD="class: tve_table_cell, colspan: 1"]Red Wine Extract
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
100mg
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
**
[/TD]
[/TR]
[TR="class: tve_table_row"]
[TD="class: tve_table_cell, colspan: 1"]AstraGin
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
50mg
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
**
[/TD]
[/TR]
[TR="class: tve_table_row"]
[TD="class: tve_table_cell, colspan: 1"]Proprietary Blend of
72 Trace Minerals

[/TD]
[TD="class: tve_table_cell tve_valign_middle, colspan: 1"]
100mg
[/TD]
[TD="class: tve_table_cell, colspan: 1"]
**
[/TD]
[/TR]
[TR="class: tve_table_row"]
[TD="class: tve_table_cell, colspan: 1"]*%DV are based on a 2000 calorie diet
**Daily value not est

[/TD]
[/TR]
[/TABLE]

 
magnus68, I think the advertising is misleading, it's L-Arginine with vitamins added. I refer to supplement my own vitamins.
 
I would not buy that primarily that it's 5g of Arginine which we know only about 40% of that is going to be processed to NO. I further don't like much of anything that says Proprietary Blend...you have no idea what that is or what's in it. Products like this that try to do many things rarely do any of them effectively. Plus I think personally, ~1g of Citrulline is rather low dosed.
 
while continuing my test/nand/dhea/serm/etc combo taken to combat a muscle-wasting illness, i thought i'd give an abbreviated version of gene's no stack a try, based on what both he and the dude have written. i'm a little confused about a few things, however. so, here's what i'm taking and some questions.

1/ liquid cia, maybe 2mg x 2 times daily; ie, two drops licked off the palm of my hand. i tried more but the constant-boner-factor got to be a little much.

2/ citrulline, 1 tsp x 2 times daily, morning and bedtime.

3/ grape seed extract, 250mg, morning and bedtime.

4/ Activz beet root powder. The Dude is no longer on the forum, I don't think, but the last thing I read from him about Activz is he took 2 teaspoons once a day along with the Citrulline. Earlier in the thread, however, he seemed to be taking 1/2 teaspoon of a beet powder that was half as strong as the Activz. Is anyone here using this stuff and if so, how much are you taking?

The Dude also said he dumped the powders into his mouth dry, because the stuff activates NO better that way or some such. Does everyone do it like that? I've tried it and it's not a pleasant experience. Wouldn't mixing it with water be okay too? Or, in other words, how are you downing this stuff?

The boner factor has been pretty fun to experience, since it's been probably over a decade since I've woken up with wood. But, I'm not taking the stack for reasons of ED or similar. My understanding is that the mix has anti-inflammatory properties and that's what I'm after mostly. (I also don't care about pumps and inflated veins, mainly cause there'd be no point; my genetics are horrible; i'm a classic skinny-fat hardgainer who might be better termed a nevergainer....)

Anyway, thanks for your thoughts!
 

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