Gene's Nitric Oxide Stack

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)

Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)

More Than a Muscle Pump: The Surprising Science of the Nitric Oxide Stack​

In the biohacking world, we often chase complex peptides or experimental compounds, but we frequently overlook the most fundamental currency of life: blood flow. In the quest for longevity, systemic vascular efficiency is the baseline upon which all other health markers are built. As we age, our ability to maintain vasodilatory capacity diminishes, impacting everything from cognitive sharpness to metabolic health. "Gene’s Nitric Oxide Stack," a protocol born and refined within the ExcelMale community, has emerged as a definitive solution for men seeking to optimize this system. This isn't just a gym supplement routine; it is a sophisticated approach to anti-aging that leverages amino acids and targeted pharmaceutical interventions to restore the body’s most vital delivery mechanism.

Beyond the Mirror: The Science of the Sustained Pump​

For the average gym-goer, the "pump" is a transient aesthetic goal—a fleeting moment of muscle fullness. However, for a longevity specialist, a "harder pump" and increased vascularity are indicators of high-functioning endothelial health. The Nitric Oxide Stack is engineered to produce a state of vasodilation that doesn't simply vanish when you rack the weights.

By optimizing the nitric oxide signaling pathway, this protocol facilitates a sustained pump that carries through your daily life. This is a critical distinction: the visual vascularity is a proxy for your body’s ability to keep its "pipes" open. When you maintain that fullness hours after a workout, you are essentially providing proof of concept that your circulatory system is operating at peak efficiency, ensuring constant nutrient delivery to peripheral tissues.

The Foundation of Performance: Hard Science for Sexual Vitality​

One of the most immediate benefits of systemic vasodilation is the restoration of sexual function. From a clinical perspective, erection quality is often the "canary in the coal mine" for cardiovascular health. Because the Nitric Oxide Stack focuses on the root physiological requirements of performance—blood flow and retention—it provides a robust alternative to temporary fixes.

A Serious Solution for Erection Quality and Duration

This stack addresses both the quality and the duration of erections with clinical precision. For men navigating the aging process, this is not a matter of vanity, but of maintaining vital physiological function. By ensuring the vascular system can respond effectively to neurological signals, the protocol allows for a level of performance that many mistakenly believe is lost to time.

The Ultimate Nootropic: Future-Proofing the Neocortex​

Perhaps the most compelling argument for nitric oxide optimization is the "bodybuilder to brain health" pipeline. While most men start this stack for its physical benefits, they are unknowingly deploying a powerful shield against age-related cognitive decline. As we age, the micro-vasculature within the brain tends to narrow and tighten, a process that starves the brain of oxygen and is a primary driver of age-related dementia.

The stack acts as a nootropic by ensuring that the brain's smallest vessels remain dilated and resilient. This ensures that the neocortex and other critical regions receive a constant supply of the nutrients required for cognitive longevity. As the source material highlights:

"by increasing nitric oxide and getting that vascular dilation we're getting oxygen blood and nutrients in the areas of the brain that can provide us with a great anti-aging benefit in terms of neurological health."

The irony is profound: a protocol often associated with the bicep curl may actually be one of your most effective tools for protecting your mind.

Systemic Management: Blood Pressure and Prostate Function​

The benefits of the stack extend into the deeper mechanics of men’s health, specifically regarding the relaxation of smooth muscle tissue. This is particularly relevant for Benign Prostate Hyperplasia (BPH) and blood pressure management. Nitric oxide serves as a signal for these tissues to relax, directly easing the "inability to ease the problems" that typically characterize age-related prostate issues.

The secondary physiological advantages of this systemic relaxation include:

• Vascular Tension Reduction: Significant support for maintaining healthy blood pressure levels by reducing resistance within the arterial walls.
• Prostate Relief: Improvement in quality of life by relaxing the prostatic smooth muscle, easing the mechanical symptoms of BPH.
• Reduced Cardiac Load: By improving systemic flow, the heart is not required to pump against the same level of resistance, preserving cardiovascular longevity.

The Future of Your Vascular Health​

"Gene’s Nitric Oxide Stack" is far from a theoretical exercise; it is a "living protocol" backed by years of community peer-review within the ExcelMale community. The "enormously long" and widely viewed thread on ExcelMale.com serves as a testament to the real-world efficacy of this stack, offering a repository of shared experiences and optimization strategies.

This multi-front approach to anti-aging represents the best of biohacking: using fundamental biological pathways to solve complex aging problems. By focusing on the delivery system itself, we can protect our brains, our hearts, and our vitality simultaneously.

If blood flow is the delivery system for every nutrient your body needs, what happens to your longevity when you finally optimize that system?


More on Nitric Oxide in Men:

Nitric Oxide Pages

 

Just got in the Liquid Cia yesterday. Took 5mg at 2pm, within 2 hours experienced the same side effects of Cialis. Facial flush, stuff nose, slightly weird feeling Cialis gives. Took 5mg at bedtime. No obvious results yet as far as creating massive erection. Cialis 5mg never did much for me right away, nor did 10mg as a reliable erection helper. I was on amlodipine for 4 years for BP. Recently move to a new house and cooking at home every meal versus eating out every meal like my old place. After reading 4 hour body, I have been trying to remove any source of veg oil from my diet. Added regular POM juice several times daily, Cod Liver Oil Super D, zinc, mag, DHEA, potass. The past month, I stopped the 5mg amlodipine and started monitoring to see my baseline. 90% of resting states are below 120/80. ie 118/78 in bed last night and the same waking up. There are times it is lower, ie 108/68. My goal is to get a reliable erection, not really much for working out. Decent shape 6' 202lb very active 52yo, should be 190 or 185 if I really wanted my thinnest possible look. 10 years ED. One thing for many younger guys on here talking about ED is they don't mention porn and masturb habits, which can certainly have an effect on erection.

I started Genes stack minus the cia and other drug last Saturday. Noticed increased night time wood right away. However night time wood never really translates to usable erection in the real world for me. For example, a massive boner at 4 am does not mean massive boner at 8 am on demand if there were a real need for it. After starting the stack last Saturday, I am noticing my left eyelid fluttering or spasming regularly many times throughout the day. I may need to cut out 1 ingredient at a time to see what the culprit is, as this is a brand new thing.

A urologist did the injection test years back and I get pretty solid, but never proceeded to order the products. I see Gene talking about Trimix, so I assume he means injectable version. I had hoped to avoid that route but may have to bite the bullet if the stack does not produce consistent and reliable erection in a few weeks. The side effects of cia are too much a hassle, but I have never tried a daily routine to see if they would fade over time.

There is a good source of stuff in the watermellon rind(citri), and Whole Foods will juice the watermelon for you into a bottle including the rind, tastes great. I am trying this some this week. Beet juice is in most grocery stores as well as POM, all good for nitrates. I read that regular mouthwash did not kill the nitrate bacteria, only the pharma type mouthwashes? I have tried getting rid of mouthwash for 2 months, no obvious changes.

I give some feedback after a week of 5mg cia added to the other stuff.

 

Ive noticed less of an affect of my LiqCia after taking HGW. I know it is also suppose to lower blood pressure too but mine seems to be elevated. We are all diffreent and it may also be the TRT Im taking (as to ncreased TRT). Just had labs done and waiting on the results. I did find this though from Ray Sahelian MD specific to HGW:


Prescription drug and medication interactions, safety of combining with pharmaceuticals
Almost all herbs used for sexual enhancement have not been tested in combination with prescription medications. As a general rule, if your doctor approves, you can start with half of a capsule for a few days and gradually increase the dosage if no side effects are noticed. Each person has a different response to herbal supplements and it is not easy to predict what benefits and adverse reactions a person will experience when taking an herbal preparation or combining it with medications.Molecules. 2013. Herb-drug interaction of Epimedium sagittatum maxim extract on the pharmacokinetics of sildenafil in rats. HGW is one of the herbs used to treat erectile dysfunction in Traditional Chinese Medicine. Sildenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction in Western Medicine. This study evaluates the herbal-drug interaction of Epimedium sagittatum extract on the pharmacokinetics of sildenafil in rats by ultra-performance liquid chromatography. The rat plasma was sampled from each anesthetized rat after pretreatment with 3-days Epimedium sagittatum extract (1/2 g/kg/day) and intravenous injection with sildenafil (10/30 mg/kg). The pharmacokinetic data demonstrate that the area under the concentration-time curve (AUC) of sildenafil (10 mg/kg) was significantly decreased in groups that received a high dose of horny goat weed extract. In conclusion, the study demonstrates that there was significant herb-drug interaction of HGW on the pharmacokinetics of sildenafil at low and high daily doses, suggesting co-administration use of Epimedium sagittatum extract and sildenafil in clinical practice should be prevented due to possible herb-drug interactions.

I don't suggest the use of sex herbs in those who are on heart medications since these aphrodisiac herbs have a tendency to speed heart rate and some may raise blood pressure. If your doctor knows your condition well and feels comfortable having you start on a low dose, that could be appropriate.

 

I switched to these pills from the Arginine powder over a week ago.

Nitrulline from Vitamin Shoppe:
Arginine Alpha-Ketoglutarate - (A-Akg) 3000mg
L-CITRULLINE MALATE 1000mg
L-Taurine 500mg
Alpha Lipoic Acid 25mg
BIOPERINE - (BLACK PEPPER EXTRACT) 5mg

Daily Routine:
Liquid Cia afternoon and night 5mg
3 pills Nitrulline morning, noon, night total 9 pills daily
50mg pycnogenol morning, noon, night total 150 mg daily
150mg icarrin morning, noon, night total 450mg daily Vitamin Shoppe Horny Goat week especially for men


2 eggs with yoke for breakfast ( I heard the cholesterol was needed for testosterone)
POM daily, various amounts
Most days I take Carlson Super D Cod Liver Oil 2 teaspoons am, 2 at night

Results at 3 weeks in: rock hard on demand any time. Cialis was never reliable before. Over 10 years dealing with this issue, appears to be solved and confidence has gone from 0 to 100%

Thanks Gene!

 

I switched to these pills from the Arginine powder over a week ago.

Nitrulline from Vitamin Shoppe:
Arginine Alpha-Ketoglutarate - (A-Akg) 3000mg
L-CITRULLINE MALATE 1000mg
L-Taurine 500mg
Alpha Lipoic Acid 25mg
BIOPERINE - (BLACK PEPPER EXTRACT) 5mg

Daily Routine:
Liquid Cia afternoon and night 5mg
3 pills Nitrulline morning, noon, night total 9 pills daily
50mg pycnogenol morning, noon, night total 150 mg daily
150mg icarrin morning, noon, night total 450mg daily Vitamin Shoppe Horny Goat week especially for men


2 eggs with yoke for breakfast ( I heard the cholesterol was needed for testosterone)
POM daily, various amounts
Most days I take Carlson Super D Cod Liver Oil 2 teaspoons am, 2 at night

Results at 3 weeks in: rock hard on demand any time. Cialis was never reliable before. Over 10 years dealing with this issue, appears to be solved and confidence has gone from 0 to 100%

Thanks Gene!

Same exact products I use and frequency, but I have replaced the HGW with Beet Root powder. Works good.

 

Does anyone know of Pmegranate pills/capsules and the POM juice...I find POM brand to be somewhat cost prohibitive...the active ingredients are the same, in other words...pills/capsules just as effective as the juice?

 

Does anyone know of Pmegranate pills/capsules and the POM juice...I find POM brand to be somewhat cost prohibitive...the active ingredients are the same, in other words...pills/capsules just as effective as the juice?

I'd like to know the answer, as well.

 

Does anyone know of Pmegranate pills/capsules and the POM juice...I find POM brand to be somewhat cost prohibitive...the active ingredients are the same, in other words...pills/capsules just as effective as the juice?

X3

I've also been wondering if taking beet root/pomegranate in capsule form is as effective as beet root powder due to pills having very limited exposure to the bacteria in the mouth. Obviously saliva is swallowed, but not sure if there is a material difference in the interaction between bacteria & beet root in the mouth vs. in the stomach.

 

I was offered a sample size of any product from BulkSupplements and chose their Pomegranate Extract. Ive used the Beet Root powder and found it utterly undrinkable. for me.

 

I take the beet root poweder capsules from Nature's Way and they are cheap and effective

 

Does anyone know of Pomegranate pills/capsules and the POM juice...I find POM brand to be somewhat cost prohibitive...the active ingredients are the same, in other words...pills/capsules just as effective as the juice?

No studies that I'm aware of. Seems unlikely though, firstly because pills are generally cut with crap, secondly because naturally occurring plant substances typically degrade from heat, moisture and oxidation during processing. It really depends upon which of the many compounds in the fruit are providing the various benefits attributed to the fruit.

Of the juices Langers ( 100% fresh pressed version only) seems clearly superior to POM from concentrate as I reported here in an unscientific comparison:
https://www.excelmale.com/forum/sho...s-prostate-cancer-cells&highlight=pomegranate

If the Langers isn't available a low temperature processed liquid PFE would seem the next best alternative. A review of one of the published studies might lead to a reliable source. The "fresh pressed" Langers must be flash pasteurized at bottling making any perceived advantage over the juices derived from concentrate subjective. In the absence of data I tend to trust my taste buds.

 

A study by researchers at UC might shed some light on what's inside commercially available "pomegranate" capsules:
http://www.nutraingredients-usa.com...stions-pomegranate-supplement-standardization

27 supplements were tested by HPLC for typical pomegranate tannin profile. 17 had minor or no detectable pomegranate tannins but had some eliagic acid. Five (5) had neither the tannins nor the eliagic acid!

This demonstrates how "standardized" pills, powders and extracts can be doctored, if the manufacturer bothers at all, with a single substance, in this case eliagic acid, quite likely from a foreign source, to make the product seem genuine.

Therefore, a relative pure compound such as Arginine is likely a safer bet to purchase in supplement form than what is alleged to be a complex extract such as PFE.

 

Gene,

I'm interested in the Nitric Oxide stack where do i get the ingredients ?

Patrick

 

Amazon...otherwise the Doxazosin and Cialis are prescription drugs.

 

Gene,

I'm interested in the Nitric Oxide stack where do i get the ingredients ?

Patrick

I think Webvitamins.com has the best price on these two specific items. Free shipping too.

Pycnogenol & Grapeseed Extract 50mg 120 Tablets
&
L-Citrulline 1200 mg Extra Strength 120 Tablets

 

I think Webvitamins.com has the best price on these two specific items. Free shipping too.

Pycnogenol & Grapeseed Extract 50mg 120 Tablets
&
L-Citrulline 1200 mg Extra Strength 120 Tablets

View attachment 1862

You'd think if ingredient used was Pycogenol brand they would identity it that way on the pkg. There is no photo only a summary on that page. Does your bottle included any assurance that only 100% Pycogenol brand is used? If so what strength?

Sloan Kettering feels that the French maritime bark extract has identical potency.

https://www.excelmale.com/forum/sho...some-thought-I-d-pass-it-on&p=33957#post33957

 

I'm wondering if this stack can be just as good without useing 1 mg of Doxazosin? After reading some of the side effects I'm a little unsure of using it, especially without a prescription. Everything else looks great, I'm hoping to try it...Thanks

 

I'm wondering if this stack can be just as good without useing 1 mg of Doxazosin? After reading some of the side effects I'm a little unsure of using it, especially without a prescription. Everything else looks great, I'm hoping to try it...Thanks

I got some Indian Doxazosin and definitely felt the side effects. Very uncomfortable and no way I was going to make it to the gym. I might try it again just to make sure it wasn't something else that day. Stack still works great without it. It's not set in stone and can be modified.

 

It has the trademark for Pycogenol on the back label. However, I originally missed that 2 tablets are needed for 50mg dose, not 1 like it assumed. Not such a great deal after all.

 

Gene or anyone else ever try adding Dopamine to this stack? I noticed APS has a product called Apomorhine.

 

I've been using N-Acetyl L-Tyrosine @ about 1g, it's a Dopamine precursor, if that's relevant.