Experiences and Questions: Personal Experiments with Oral Native Testosterone Base & Enclomiphene (TRT+), Testosterone Propionate, HCG and more

[Guided_by_Voices]

Ah yeah in your thread I also found viagra for cardiovascular health. Interesting. Can you recommend? This lowers blood pressure?

In general, poor health is accompanied by a decline in Nitric Oxide production. The Viagra class of drugs blocks an enzyme that breaks down nitric oxide so it indirectly increases Nitric Oxide if someone is producing good amounts in the first place. Dr. Kendrick points out that these drugs far outperform statins for cardiovascular health, however that gets no publicity from mainstream medicine.

Many people in poor health lack sufficient amounts of the enzyme that produces Nitric Oxide however so viagra is ineffective. Nitric oxide tablets (I use the ones from N1o1.com) or Beetroot powder which I also use can help raise Nitric Oxide, but overall good health and especially HIIT training is also critical. You can listen to the podcasts and videos by Dr. Nathan Bryan for a good summary. He has a recent podcast at Daveasprey.com for example.

I think Nitric Oxide in general lowers blood pressure but it does lots of other things as well. I think remember that cialis/viagra can lower blood pressure but that is not a permanent fix for the causes of high blood pressure in the first place.

 

[FunkOdyssey]

Another quick update: my propionate ran out today, there might be a tiny amount left, but not even 20 mg. My supplier hasn’t delivered yet. What I have on hand is native testosterone (so I could make a topical) and testosterone cypionate. I’m debating whether to start the cypionate now or try the topical, and I’m not sure what dose I’d need for cypionate. And how to transition.

I would vote cypionate, and there is no special transition method required. Just start it at the dose you plan to use. You will reach 80+ % of the final steady state levels very quickly.

 

[dirkdigglr]

ended up using the dht topical. Actually I liked the effect. gave me some buzz. had plenty of energy. actually a bit addictive. when using propionate before felt stressfull sometimes and emotionally a bit blocked. but not sure if it was because i was working all day when at home and using propionate and then while travelling there was this exciting environment. I read the e2 raises less with scrotal topical. so maybe there is a difference in amount of dht and e2 compared to propionate...

did you end up using the injectable dht enanthate? what was your experience?

 

[dirkdigglr]

I would stay on enclomiphene and use 500 IU hCG twice or three times per week, and drop everything else. Too many variables in your experiment!

with that protocol (adding hcg) how would you handle high estrogen and shbg in that case? when using 6mg enclomiphene every 3 days I had high shbg, but estrogen was still in reference range. Also what would be benefit of hcg added to enclomiphene?

• Estradiol (E2): 43.6 pg/ml
• SHBG: 80.5 nmol/l
  
  

 

[dirkdigglr]

If you do happen to run peak labs, you're going to see some shocking numbers that may bias you towards a dose reduction. 20 mg of test prop daily with hCG on top is no joke. On 19 mg of test prop without hCG, I had 1800+ ng/dL total T, 49 ng/dL free T, and 56 pg/mL E2 at peak.

yeah way too high.

Hormone Panel Comparison​

Most recent test on 20th october 2025 (+6 hours after injection of 20mg propionate and 150IUs hcg)

• Total Testosterone: >52.0 nmol/L (cut off at around 1500ng/dL)(Ref. 12.0 – 30.0) → High
• Free Testosterone: 58.47 pg/mL (Ref. 7.00 – 22.70) → High
• Estradiol (E2): 67.6 pg/mL (Ref. 11.3 – 43.2) → High
• SHBG: 43.9 nmol/L (Ref. 18.3 – 54.1) → Normal
• Free Androgen Index (FAI): not calculable (Ref. 35.0 – 92.6)
• Prolactin: 18.4 ng/mL (Ref. 4.04 – 15.2) → Slightly elevated
• Albumin: 45.9 g/L (Ref. 35.0 – 52.0) → Normal

any idea how Free Testosterone: 58.47 pg/mL (Ref. 7.00 – 22.70) can be converted?

---

Older test on 01.08.25 (through, 24h post injection)

• Total Testosterone (trough, 24 h): 45.2 nmol/L (≈ 1303 ng/dL) — Ref. 8.64 – 29.0 nmol/L → High
• Estimated Free Testosterone (Vermeulen): 1.08 nmol/L (≈ 31.15 ng/dL / 2.4 %) → High (estimate)
• Estradiol (E2): 42.5 pg/mL (Ref. 11.3 – 43.2) → Upper-normal
• SHBG: 37.8 nmol/L (Ref. 18.3 – 54.1) → Normal
• Prolactin: 14.5 ng/mL (Ref. 4.04 – 15.2) → Normal

Varies widely, but I would say the possible ranges are something like this:

Total T: 75 - 200 ng/dL
Free T: 2 - 4 ng/dL
E2: 10 - 25 pg/mL

Chatgpt said that 150IUs should restore around 75% of production? If you are not hypogonadal in first place then would you get 75% of your full natural production? or maybe I understood something wrong.

Use this site for Vermeulen free T. With TT of 45.2 nMol/L, SHBG of 37.8 nMol/L and albumin at 4.38 g/dL you get cFTV of 1.08 nMol/L, which is over 31 ng/dL. The top of the normal range for this is in the low 20s. In line with what @FunkOdyssey said, your peak level could easily be two or three times this.

any idea how Free Testosterone: 58.47 pg/mL (Ref. 7.00 – 22.70) can be converted?

 

[dirkdigglr]

I administered a 20% self-prepared scrotal testosterone cream, 100 mg twice daily, + 150 IUs hcg daily and experienced overstimulation. Very interesting are the very high DHT values. The following labs show the hormonal impact:

~5.5h after applying 20% scrotal cream​

• Total Testosterone: 49.7 nmol/L (ref: 8.64–29.0) → ≈ 1433 ng/dL
• Free Testosterone: 42.4 pg/ml (ref: 7.00–22.7)
• DHT: 3290 pg/ml (ref: 300–850)
• SHBG: 41.9 nmol/L (ref: 18.3–54.1)
• Estradiol (E2): 28 pg/ml (ref: 11.3–43.2)

---

another test: ~12-14h after last dose​

• Total Testosterone: 27.0 nmol/L (ref: 12.0–30.0) → ≈ 780 ng/dL
• Free Testosterone: 17.88 pg/ml (ref: 7.0–22.7)

---

Short Interpretation:​

Scrotal application created a dramatic androgen spike:

• Free T nearly doubled above range
• DHT exploded to 3290 pg/ml vs a reference of 300–850, confirming intense local 5-alpha-reductase conversion.
  After ~12h without dosing, values significantly decreased toward the upper-normal range.
• It made me feel overstimulated and anxious, and my sleep became shorter and fragmented. I eventually felt burned out, with an almost compulsive drive toward stimulation

 

[dirkdigglr]

I switched now to 10mg testosterone propionate + 150 IU HCG, and also added 200mg Iboga which is probably around 6 to 8 mg ibogaine hcl. And I have to say — this feels very, very interesting. The Iboga effect is honestly fascinating. I’ve heard that it kind of “resets” or re-learns patterns and basically rewires parts of the reward system — and I can actually feel that. Everything feels smoother and calmer now.


It made me realize that my brain and reward center were actually messed up before — probably from stimulants, high-dose testosterone, dopamine overstimulation, etc. Now with Iboga, my cravings for stimulation are basically gone — cravings for fast food, sex, compulsive dopamine chasing — it’s just quiet. The simplest things feel satisfying again — nature, simple food, just being grounded.

It also feels like I’m more organized and structured in my day, and I waste way less time. And something else — I feel like I can connect with people better, more genuinely, more integrated as a person. Hard to explain — but it’s noticeable.

Of course, there’s a caveat: I’ve read that Iboga is cardiotoxic in rat studies, even at microdoses — and potentially stressful for liver and kidneys. I heard about iboga at a psychedelic congress where they also talked about microdosing protocols, cultural contexts, and different dosing traditions. And later saw it in videos like huberman labs youtube video I’m not sure about availability of non-toxic analogues exist, but I’ve got to say — the effect is extremely impressive. This stuff does something real.