Estradiol Ultra-sensitive??

But because e2 is normal and the ultrasensitive is above? shouldn't they both be normal?
No not really, Labs aren’t always the same. Because most members are on testosterone they have higher E2 levels. Most issues are caused by too low of estradiol levels. Because of AI.
 
NO, you should not take an AI. Quest and LabCorp estradiol ranges are derived from men not on TRT who usually have total T over 600 ng/dl

Read this



 
NO, you should not take an AI. Quest and LabCorp estradiol ranges are derived from men not on TRT who usually have total T over 600 ng/dl

Read this




but how much estradiol is acceptable to avoid gynecomastia?
 
but how much estradiol is acceptable to avoid gynecomastia?




I would be much more concerned with one having low T/high e2 and even then true gynecomastia will only happen in the genetically prone.

Keep in mind that on trt we are not abusing testosterone when it comes to the doses used.




INTRODUCTION—DEFINITION

Gynecomastia (GM) is a benign proliferation of glandular tissue of the breast in men.
The term is derived from the Greek words ‘gyneka’ (woman) and ‘mastos’ (breast). GM can be unilateral or bilateral, most commonly the latter (Nuttall, 1979; Mieritz et al., 2017). GM has to be distinguished from pseudogynecomastia (i.e., lipomastia), which is characterized by excess fat deposition without glandular proliferation. GM is a common condition with a prevalence that varies widely between 32 and 65%, depending on the age of the subjects studied and the criteria used for GM definition (Braunstein, 2007). GM shows three discrete peaks throughout a man’s lifespan: the first peak is observed during infancy, the second during puberty, and the third in middle-aged and elderly men (Nachtigall, 1965; Knorr & Bidlingmaier, 1975; Nuttall, 1979). The purpose of the assessment of GM should be the detection of underlying pathological conditions and the discrimination from other breast lumps that mimic GM, particularly breast cancer.






Figure 3 Causes of gynecomastia with an adult debut in men with no substance abuse. Reprinted by permission from Bioscientifica Limited, European Journal of Endocrinology, Gynaecomastia in 786 adult men: clinical and biochemical findings, Mieritz et al. (2017).
1607795144230.webp
 
After reading papers on gynecomastia for years, I really believe gynecomastia happens in men with genetic predisposition who also happen to have low T and high IGF-1 with high estradiol. Men on TRT should really not get gynecomastia unless they stop TRT and go into hypogonadal state and meet the hormone profile I just mentioned.
Bodybuilders on growth hormone (high IGF1) plus anabolics that stop T may have a higher risk of gynecomastia.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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