Estradiol Ultra-sensitive??

[gerson]

Hello friends
My e2 Ultra-sensitive is 34 ... normal is up to 29
Should I take adex?
Thank you

 

[UCFguy01]

No

 

[gerson]

Other doubt
E2 blood test 38 range 42
But Ultra-sensitive 34 range 29

Why the difference? Which one is correct?

 

[Vince]

Other doubt
E2 blood test 38 range 42
But Ultra-sensitive 34 range 29

Why the difference? Which one is correct?

Both levels are good, don’t take an AI

 

[Vince]

Before You Post About Estradiol or Anastrozole- READ THIS FIRST - Excel Male TRT Forum

Estradiol (E2) frightens a lot of men with low T or on TRT. It’s perceived - all too often - as an almost wicked hormone, lurking, waiting to undermine a patient’s TRT protocol. Guys fear it will rob them of their erections and sex drive and cause them to grow breasts. Estradiol is a necessary...

www.excelmale.com

 

[gerson]

Both levels are good, don’t take an AI

But because e2 is normal and the ultrasensitive is above? shouldn't they both be normal?

 

[Vince]

But because e2 is normal and the ultrasensitive is above? shouldn't they both be normal?

No not really, Labs aren’t always the same. Because most members are on testosterone they have higher E2 levels. Most issues are caused by too low of estradiol levels. Because of AI.

 

[gerson]

was reading in Nelson Vergel's book he says that during TRT up to 50 is acceptable for estradiol, but this value is for sensitive or ultrasensitive e2

 

[Vince]

was reading in Nelson Vergel's book he says that during TRT up to 50 is acceptable for estradiol, but this value is for sensitive or ultrasensitive e2

I believe now, he changed that to 60.

 

[Nelson Vergel]

NO, you should not take an AI. Quest and LabCorp estradiol ranges are derived from men not on TRT who usually have total T over 600 ng/dl

Read this

How to Predict Estradiol and DHT at Different Testosterone Doses - Excel Male TRT Forum

I was able to come up with a table using the predictive model equation derived from data in this study: The Effects of Injected Testosterone Dose and Age on the Conversion of Testosterone to Estradiol and Dihydrotestosterone in Young and Older Men Summary This video discusses a research paper...

www.excelmale.com

Google Search

 

[gerson]

NO, you should not take an AI. Quest and LabCorp estradiol ranges are derived from men not on TRT who usually have total T over 600 ng/dl

Read this

How to Predict Estradiol and DHT at Different Testosterone Doses - Excel Male TRT Forum

I was able to come up with a table using the predictive model equation derived from data in this study: The Effects of Injected Testosterone Dose and Age on the Conversion of Testosterone to Estradiol and Dihydrotestosterone in Young and Older Men Summary This video discusses a research paper...

www.excelmale.com

Google Search

but how much estradiol is acceptable to avoid gynecomastia?

 

[madman]

but how much estradiol is acceptable to avoid gynecomastia?

I would be much more concerned with one having low T/high e2 and even then true gynecomastia will only happen in the genetically prone.

Keep in mind that on trt we are not abusing testosterone when it comes to the doses used.

Gynecomastia Evaluation and Treatment: EAA clinical practice guidelines - Excel Male TRT Forum

ABSTRACT Background Gynecomastia (GM) is a benign proliferation of the glandular tissue of the breast in men. It is a frequent condition with a reported prevalence of 32–65%, depending on the age and the criteria used for definition. GM of infancy and puberty are common, benign conditions...

www.excelmale.com

INTRODUCTION—DEFINITION

Gynecomastia (GM) is a benign proliferation of glandular tissue of the breast in men. The term is derived from the Greek words ‘gyneka’ (woman) and ‘mastos’ (breast). GM can be unilateral or bilateral, most commonly the latter (Nuttall, 1979; Mieritz et al., 2017). GM has to be distinguished from pseudogynecomastia (i.e., lipomastia), which is characterized by excess fat deposition without glandular proliferation. GM is a common condition with a prevalence that varies widely between 32 and 65%, depending on the age of the subjects studied and the criteria used for GM definition (Braunstein, 2007). GM shows three discrete peaks throughout a man’s lifespan: the first peak is observed during infancy, the second during puberty, and the third in middle-aged and elderly men (Nachtigall, 1965; Knorr & Bidlingmaier, 1975; Nuttall, 1979). The purpose of the assessment of GM should be the detection of underlying pathological conditions and the discrimination from other breast lumps that mimic GM, particularly breast cancer.






Figure 3 Causes of gynecomastia with an adult debut in men with no substance abuse. Reprinted by permission from Bioscientifica Limited, European Journal of Endocrinology, Gynaecomastia in 786 adult men: clinical and biochemical findings, Mieritz et al. (2017).

 

[Nelson Vergel]

After reading papers on gynecomastia for years, I really believe gynecomastia happens in men with genetic predisposition who also happen to have low T and high IGF-1 with high estradiol. Men on TRT should really not get gynecomastia unless they stop TRT and go into hypogonadal state and meet the hormone profile I just mentioned.
Bodybuilders on growth hormone (high IGF1) plus anabolics that stop T may have a higher risk of gynecomastia.