CDC STANDARDIZED TOTAL T and ESTRADIOL ASSAYS and soon to be FREE TESTOSTERONE!

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madman

Thread 'Free T vs Total T - Cutoffs and Symptoms - Where Are the Data?'

25th Annual Fall Scientific Meeting of SMSNA!

Grapevine, Texas.




1:14:05-1:29:40
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Recommendatios for Dealing with Free T
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Concept of Total Hormonal Load
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Keep in mind all those men with normal TT and high SHBG!

Reasonable, Evidence-based Recommendation for Managing T
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madman

Thread 'How to Avoid a Mad "T" Party: Evaluation and Management of Male Hypogonadism'

One of the big boys in the field!

Dr. Anawalt!

Pay attention to the Q&A (43:20-56:30) especially when it comes to testing free testosterone!




43:20-46:27 - How do we assess for free testosterone?

* There's a direct antibody assay (IA) that measures free testosterone it is notoriously inaccurate and notoriously underestimates the true free testosterone as much as 30% so you should never use that but it is cheap, its easy, its quick so all labs offer it








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madman

Thread 'Hormone Health at Risk: Why Europe Is Failing to Fund Endocrine Research—and How EndoCompass Aims to Fix It'

* Standardization and harmonization offer the possibility to make laboratory test results more comparable. Standardization refers to the process of achieving agreement between hormone tests by establishing traceability to a recognized standard reference material through a high-order primary reference material (RM) and/or reference material procedure (RMP); it concerns mainly inert hormones such as steroids.


* The quality of analyses in endocrinology is challenging but crucial. High-quality analyses ensure the reliability of research conclusions and interpretation of patient...
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madman

Thread 'The Changing Landscape in the Assessment of Steroid Hormone concentrations: is it time to let them free? (CLASH-free)'

* With CLASH-free, we will improve the clinical applicability of free steroid hormone concentrations in patients with specific conditions by using state-of-the-art methods.


* Formulas to estimate free steroid hormone concentrations are used instead, but their applicability in many clinical conditions is questionable, so is the correctness of therapeutic actions based on these results.


* We will improve current formulas to better estimate free hormone levels.





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Research Portal - The Changing Landscape in the Assessment of Steroid Hormone concentrations: is it time to let them free? (CLASH-free)

Steroid hormones such as testosterone or vitamin D are vital forhuman physiology. In circulation, steroid hormones bind to specificbinding proteins and albumin, with only a small fraction circulatingfreely. The ‘free hormone hypothesis’ suggests that this free fractionis responsible for...
research.kuleuven.be
...
 
So many doctors still clueless when it comes to the most critical fraction free testosterone!

Shame on those still using/relying on the known to be inaccurate direct IA!


* The assays for measuring free testosterone are not standardized and have high levels of imprecision and inaccuracy. The reference ranges for free testosterone vary substantially among laboratories rendering it difficult to establish common diagnostic thresholds. Thus, there is a need to develop more advanced methods for measuring free testosterone and establish rigorously derived reference ranges.




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madman

Thread 'Endocrine Society Submits Comments to FDA Expert Panel on Testosterone Replacement Therapy for Men'

Much more to the story here!


* Longer-term studies are still needed to determine whether testosterone therapy is safe with respect to cardiovascular, thromboembolic, and prostatic diseases. However, recent placebo-controlled trials (of 1-4 years) of TRT offer reassurance about the risk of cardiovascular and prostate disease (prostate cancer and lower urinary tract symptoms of benign prostatic hyperplasia, although less so for pulmonary emboli and thrombotic risk. Because the recent placebo-controlled trials of TRT excluded men at high risk of thromboembolic and...
 
madman

Thread 'Evaluation of the Siemens Atellica TSTII Testosterone Assay in the CDC HoSt-TT Program'

* The CDC Hormone Standardization Program for Total Testosterone (HoSt-TT) evaluates assay performance against ID-LC-MS/MS using clinically relevant concentrations.


* The TSTII assay is CDC HoSt-TT certified, has strong alignment to LC-MS/MS, and shows good correlation of calculated FT with equilibrium dialysis/LC-MS/MS.




Abstract

Background

Standardized testosterone measurement is essential for diagnosing hypogonadism, infertility, endocrine disorders, and monitoring therapy. The CDC Hormone Standardization Program for Total Testosterone...
 
* Generally, cFT correlates well with mFT but various proposed algorithms for calculation of FT perform unequally, giving rise to disparate results for cFT. For example, for the most-commonly used Vermeulen formula, notwithstanding an excellent correlation, a positive bias of around 20% is observed between FT measured by ED LC-MS/MS and calculations (1).


* The established reference ranges are in line with previous reports of mFT (22,33,34) and may potentially be used as a reference data set for other methods. However, before these data can be more broadly implemented in clinical laboratories and clinical care, harmonization/standardization and cross-validation of existing mFT methods are required. Harmonization/standardization initiatives are crucial to move forward, given the increasing interest in mFT. Indeed, more clinical and commercial laboratories have been developing in-house mFT methods with improved throughput and shorter dialysis times (23,35,36). However, without the existence of a reference measurement system and reference measurement procedures, the performance of existing routine methods in terms of calibration and sample related effects cannot be assessed, nor can the calibration of the assays be traceable to a common reference point. This may result in large differences between methods.




madman

Thread 'Largest dataset of mFT levels to date: male reference ranges spanning a wide age range, using a gold standard ED LC-MS/MS method'

Sit and dwell on that!

Think of all those overmedicated men on T-therapy gassed up on FT well beyond their natty genetic set-point and unfortunately many off them off the hop!

You can blame all those run of the mill T clinics, kiddie forums loaded with all those numbskulls, throw those blast n cruisers in there too and put the icing on the cake the cesspool of so called gurus polluting gootube!

Gotta love all those kiddie forums loaded with the brainwashed sheep still pushing that more T is better mentality dishing out piss poor advice!

So much misinformation littered on the net its...
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