CDC STANDARDIZED TOTAL T and ESTRADIOL ASSAYS and soon to be FREE TESTOSTERONE!

[madman]

Thread 'Free T vs Total T - Cutoffs and Symptoms - Where Are the Data?'

Oct 13, 2025

25th Annual Fall Scientific Meeting of SMSNA!

Grapevine, Texas.




1:14:05-1:29:40

Recommendatios for Dealing with Free T

Concept of Total Hormonal Load

Keep in mind all those men with normal TT and high SHBG!

Reasonable, Evidence-based Recommendation for Managing T

• madman
• cutoff/symptoms hypogonadism; testosterone; ft vs tt
• Replies: 13
• Forum: Testosterone and Men's Health Articles

 

[madman]

Thread 'How to Avoid a Mad "T" Party: Evaluation and Management of Male Hypogonadism'

Nov 2, 2025

One of the big boys in the field!

Dr. Anawalt!

Pay attention to the Q&A (43:20-56:30) especially when it comes to testing free testosterone!




43:20-46:27 - How do we assess for free testosterone?

* There's a direct antibody assay (IA) that measures free testosterone it is notoriously inaccurate and notoriously underestimates the true free testosterone as much as 30% so you should never use that but it is cheap, its easy, its quick so all labs offer it

• madman
• hypogonadism; t-therapy; diagnosis; health
• Replies: 15
• Forum: Testosterone and Men's Health Articles

• 

 

[madman]

Thread 'Hormone Health at Risk: Why Europe Is Failing to Fund Endocrine Research—and How EndoCompass Aims to Fix It'

Nov 8, 2025

* Standardization and harmonization offer the possibility to make laboratory test results more comparable. Standardization refers to the process of achieving agreement between hormone tests by establishing traceability to a recognized standard reference material through a high-order primary reference material (RM) and/or reference material procedure (RMP); it concerns mainly inert hormones such as steroids.


* The quality of analyses in endocrinology is challenging but crucial. High-quality analyses ensure the reliability of research conclusions and interpretation of patient...

• madman
• endocrine; hormones; testing standardize/harmonize
• Replies: 5
• Forum: Testosterone and Men's Health Articles

• 

 

[madman]

Thread 'The Changing Landscape in the Assessment of Steroid Hormone concentrations: is it time to let them free? (CLASH-free)'

Nov 8, 2025

* With CLASH-free, we will improve the clinical applicability of free steroid hormone concentrations in patients with specific conditions by using state-of-the-art methods.


* Formulas to estimate free steroid hormone concentrations are used instead, but their applicability in many clinical conditions is questionable, so is the correctness of therapeutic actions based on these results.


* We will improve current formulas to better estimate free hormone levels.

Research Portal - The Changing Landscape in the Assessment of Steroid Hormone concentrations: is it time to let them free? (CLASH-free)

Steroid hormones such as testosterone or vitamin D are vital forhuman physiology. In circulation, steroid hormones bind to specificbinding proteins and albumin, with only a small fraction circulatingfreely. The ‘free hormone hypothesis’ suggests that this free fractionis responsible for...

research.kuleuven.be

...

• madman
• equilibrium dialysis; cft hypogonadism; free testosterone; shbg
• Replies: 2
• Forum: Testosterone and Men's Health Articles

 

[madman]

Long overdue!

https://www.cdc.gov/clinical-standardization-programs/media/pdfs/2024/04/CDC-Certified-Testosterone-Assays-508.pdf

CDC Hormone Standardization Program (CDC HoSt) Certified Total Testosterone Procedures (UPDATED 09/2025)

 

[madman]

Quest Diagnostics still missing in action LOL!

https://www.cdc.gov/clinical-standardization-programs/media/pdfs/2024/04/CDC-Certified-Estradiol-Assays-508.pdf

CDC Hormone Standardization Program (CDC HoSt) Certified Estradiol Assays (UPDATED 9/2025)