Enclomiphene versus clomiphene study results

Among 66 patients, enclomiphene exhibited a median testosterone increase of 166 (vs. 98 ng/dL, P=0.20) with lower estradiol change than clomiphene (–5.92 vs. 17.50 pg/mL, P=0.001). Adverse effects were statistically significantly less frequent with enclomiphene, including decreased libido (P=0.001), reduced energy (P=0.044), and mood changes (P=0.03). Regression analysis confirmed lower odds of adverse events with enclomiphene [OR: 0.18; 95% confidence interval (CI): 0.07–0.44, P=0.02].

Safety and efficacy of enclomiphene and clomiphene for hypogonadal men - Saffati - Translational Andrology and Urology

 

Not randomized and see limitations.

 

Hmm, then why did the FDA not approve of “Androxal”?

Androxal (enclomiphene): What is it and is it FDA approved? - Drugs.com

Androxal (enclomiphene citrate) is a new drug in development for the treatment of hypogonadism. Androxal information includes news, clinical trial results and side effects.

www.drugs.com

I’m sure by now everyone know Enclomifene is the E-stereoisomer of clomifene, clomid is roughly 40/60 Zuclomifene:Enclomifene

 

So clomiphene is a waste of time? 47% of side effects, with 33% of people having no libido and impaired sexual function, that's a lot. What would be the reason for libido and sexual function in the rest of the population to still be active, since it tells the brain that there is not enough estrogen?

 

My 46-year-old son used clomiphene to get his 36 your old wife pregnant. He had no issues. Only great results.

He bought it from Mexico.

 

I am posting this here only because I could not figure out how to start a new thread. Not sure if anyone will see it but it is about enclomiphene. I have been on it for a month and a half at 12.5 daily dose. my testosterone actually went down from 259 to 224 so I was low to begin with. talk about a waste of time for me.