Enclomiphene versus clomiphene study results

[Nelson Vergel]

Among 66 patients, enclomiphene exhibited a median testosterone increase of 166 (vs. 98 ng/dL, P=0.20) with lower estradiol change than clomiphene (–5.92 vs. 17.50 pg/mL, P=0.001). Adverse effects were statistically significantly less frequent with enclomiphene, including decreased libido (P=0.001), reduced energy (P=0.044), and mood changes (P=0.03). Regression analysis confirmed lower odds of adverse events with enclomiphene [OR: 0.18; 95% confidence interval (CI): 0.07–0.44, P=0.02].

Safety and efficacy of enclomiphene and clomiphene for hypogonadal men - Saffati - Translational Andrology and Urology

 

[Seagal]

Not randomized and see limitations.

 

[MDavidW76]

Hmm, then why did the FDA not approve of “Androxal”?

Androxal (enclomiphene): What is it and is it FDA approved? - Drugs.com

Androxal (enclomiphene citrate) is a new drug in development for the treatment of hypogonadism. Androxal information includes news, clinical trial results and side effects.

www.drugs.com

I’m sure by now everyone know Enclomifene is the E-stereoisomer of clomifene, clomid is roughly 40/60 Zuclomifene:Enclomifene

 

[FabioXcz]

So clomiphene is a waste of time? 47% of side effects, with 33% of people having no libido and impaired sexual function, that's a lot. What would be the reason for libido and sexual function in the rest of the population to still be active, since it tells the brain that there is not enough estrogen?

 

[Vince]

My 46-year-old son used clomiphene to get his 36 your old wife pregnant. He had no issues. Only great results.

He bought it from Mexico.