Seeking sanity check on doc's advice to start TRT

plasmanut

New Member
Hey guys, new here. I'm hoping to get a sanity check before I move any further into TRT.

I'm 53 and fighting classic low T symptoms the last 3-4 years. I've put a lot of effort into improving diet, cardio, and resistance training but not seeing changes in these symptoms. Seven years ago I was diagnosed with ED (which Silldenafil helps somewhat), but in the last 3 noticed a big shift in body composition from muscle to abdominal fat. Increased resistance/core training at that point but haven't seen results but has progressively gotten worse. I've also had other classic symptoms of lower libido and losing motivation in hobbies and socializing.

A few weeks ago I had a physical and blood work with my primary care doc who did a hormone panel. Even though my numbers were all in range, he is recommending TRT as an option based on an above average SHBG value (120mg/week test cypionate administered twice weekly).

He's seen this in other patients and it has helped. He also mentioned the LH/FSH are high which tells him the body is signalling it needs more T but is not producing.

Here are my labs (Labcorp):
Total T: 564 ng/dL
SHBG: 55.8 nmol/L
Free T (calc): 81.7 pg/mL
LH: 7.0 mIU/L
FSH: 10.8 mIU/L
Estradiol: 23.0 pg/mL
PSA: 0.3 ng/mL
Hematocrit: 40.2%

Based on this, a couple of questions:
  • Does this course of treatment make sense for me with his notion of high SHBG?
  • Would it be wise to get a second opinion?
  • Would a 3 month trial allow me to determine if this is working and would it also be reversible if not?
Thanks a bunch.
 

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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