THE MYOCENTRIC VIEW OF CREATINE SUPPLEMENTATION MAY BE INCOMPLETE: BRAIN, BONE, HEART, IMMUNE SYSTEM?

[madman]

By THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION FEATURING JOSE ANTONIO, ANTHONY RICCI, DARREN CANDOW

The Myocentric View of Creatine is Incomplete

A video from Jose Antonio, Anthony Ricci, and Darren Candow (as part of The International Society of Sports Nutrition), posted on Nov 28, 2025.

www.vumedi.com

Prof. Darren Candow, PhD (University of Regina, Canada), an internationally expert in the field of creatine research.

Dr. Candow is a professor specializing in exercise physiology, nutrition, and aging. He supervises the Aging Muscle and Bone Health Laboratory, where the primary research objectives focus on developing effective lifestyle interventions involving nutrition (primarily creatine monohydrate) and physical activity (resistance training). These interventions aim to have practical and clinical relevance for improving muscle, bone, and brain health and function.

* Total-Body: ≥ 10 grams/day?


Where We are

 

[madman]

Creatine

* Nitrogen-containing compound
(arginine, glycine, methionine)

* Increased PCr stores improve the ability to re-synthesize ATP following high-intensity, short-term exercise = Bigger, Stronger, Faster.

 

[madman]

CREATINE IS MADE IN THE BODY

 

[madman]

* To date; bone and brain benefits observed with larger doses and/or long-term ingestion




'DO YOU NEED TO SUPPLEMENT WITH CREATINE'?

 

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YOUR DAILY DIET

Herring is a powerhouse!

CREATINE CONTENT

 

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Time tested creatine monohydrate!

Bill Phillips EAS Phosphagen back in the day!




THE MORE PRACTICAL SOLUTION

 

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TYPICAL 'MUSCLE' DOSING STRATEGIES

MUSCLE SUMMARY

The combination of creatine supplementation and resistance training increases:

 

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BONE

THE BONE REMODELING PROCESS

Low-Dose Creatine Combined with Protein During Resistance Training in Older Men

Effects of Creatine and Resistance Training on Bone Health in Postmenopausal Women

BONE MINERAL DENSITY

 

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Efficacy of Creatine Supplementation and Resistance Training on Area and Density of Bone and Muscle in Older Adults

BONE STRUCTURE

11 grams CM/day for 2 years!

A 2-Year Randomized Controlled Trial of Creatine Supplementation during Exercise for Postmenopausal Bone Health

BONE STRENGTH

BONE BUCKLING RATIO

 

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BONE SUMMARY

The combination of creatine supplementation (≥ 0.1 g/kg/day) and resistance training:

 

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BRAIN FUNCTION

BRAIN FUNCTION

CREATINE and BRAIN CREATINE LEVELS

DOSING/EXISTING STUDIES

 

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TBI/CONCUSSION

The only study to look at this.

RESULTS

 

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OTHER AREAS OF RESEARCH

Preventative creation supplementation/Therapeutic creatine supplementation

 

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SAFETY

Longest study ever to look at the highest dose of creatine ever in a population that is already exposed to kidney and liver deterioration

11 grams CM/day for 2 years!

 

[madman]

* Total-Body: ≥ 10 grams/day?




Where We are

 

[madman]

Thread 'Creatine in Older Adults (Muscle/Bone/Brain)'

Jul 22, 2025

The Creatine Conference 2025 is honored to welcome Prof. Darren Candow, PhD (University of Regina, Canada), an internationally expert in the field of creatine research. In this keynote, Dr. Candow presents the latest research on creatine supplementation in older adults, focusing on its benefits for muscle strength, bone health, and cognitive function.

Dr. Candow is a professor specializing in exercise physiology, nutrition, and aging. He supervises the Aging Muscle and Bone Health Laboratory, where the primary research objectives focus on...

• madman
• creatine; muscle; bone; cognitive health
• Replies: 3
• Forum: Nutrition and Supplements

 

[madman]

Thread 'The science-backed safety profile of creatine supplementation, addressing myths, clinical evidence, and long-term outcomes in +650 human studies'

Jul 22, 2025

Read the full article here
Kreider, R. B., Gonzalez, D. E., Hines, K., Gil, A., & Bonilla, D. A. (2025). Safety of creatine supplementation: analysis of the prevalence of reported side effects in clinical trials and adverse event reports. Journal of the International Society of Sports Nutrition, 22(sup1). https://doi.org/10.1080/15502783.2025...

The Creatine Conference 2025 welcomes Prof. Rick Kreider, PhD (ESNL, Texas A&M University), a leading global expert on creatine research. In this keynote, Dr. Kreider examines the science-backed...

• madman
• creatine; myths; safety; health/disease
• Replies: 4
• Forum: Nutrition and Supplements

• 

 

[madman]

Thread 'Why 5g of Creatine Isn’t Enough for Your Brain'

Dec 30, 2025

Dr. Darren Candow

* 3-5 g is great for muscle

* 8-10/8-12 g is good for bone

* I think the sweet spot is 10 g for the whole body

Join Dr. Altamash Raja and Dr. Darsh Shah on Medicine Redefined as they introduce Dr. Darren Candow, a leading researcher on creatine supplementation. The episode dives into the benefits of creatine, not just for muscle performance, but also for brain health, bone density, and cardiovascular health. Addressing myths and misconceptions, the conversation highlights creatine's...

• madman
• creatine; muscle; brain; bone; immune system
• Replies: 2
• Forum: Nutrition and Supplements

 

[madman]

Thread 'Creatine for Health and Performance'

Dec 30, 2025

Summary

• madman
• creatine; health/fitness; aging
• Replies: 36
• Forum: Nutrition and Supplements

•