The Link between Thyroid Function and Depression - PMC
The relation between thyroid function and depression has long been recognized. Patients with thyroid disorders are more prone to develop depressive symptoms and conversely depression may be accompanied by various subtle thyroid abnormalities. ...
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"Patients with thyroid disorders are more prone to develop depressive symptoms and conversely depression may be accompanied by various subtle thyroid abnormalities. Traditionally, the most commonly documented abnormalities are elevated T4 levels, low T3, elevated rT3, a blunted TSH response to TRH, positive antithyroid antibodies, and elevated CSF TRH concentrations. In addition, thyroid hormone supplements appear to accelerate and enhance the clinical response to antidepressant drugs."
"Today, it is well recognized that disturbances in thyroid function may significantly affect mental status including emotion and cognition. Both excess and insufficient thyroid hormones can cause mood abnormalities including depression that is generally reversible with adequate thyroid treatment. On the other hand, depression can be accompanied by subtle thyroid dysfunction. Overt thyroid disease is rare in depression. One to 4% of patients with affective disorders are found to have overt hypothyroidism while subclinical hypothyroidism occurs in 4% to 40% of these patients [2]. Furthermore, thyroid hormones are reported by many authors to be an effective adjunct treatment for depression."
"In patients treated with T4, psychological symptoms may persist even when they achieve a euthyroid state [16]. Impaired psychological wellbeing in these subjects may be related to the occurrence of genetic polymorphisms in the D2 gene [17] as well as the OATPC1 encoding gene [18]."
"An acceleration of antidepressant effect by T3 has been initially shown more than 30 years ago in several reports [63–66]."
Then of course these authors aren't convinced that thyroid supplementation works/helps: Hypothyroidism and Depression
This one points to a correlation with subclinical hypothyroidism and depression: Hypothyroidism and Depression
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