Testosterone Replacement Therapy and No HCG

Fernando Almaguer

Well-Known Member
I have heard that not using HCG concurrently with TRT will cause shrikage of improtant testicular cells and death over time. Rendering the balls damaged. I have also heard that HCG is not necessary if one does not feel good on it. And we can regain fertility just by adding a fertility protocol like HCG, HMG, nolvadex, clomid, ect.

So, because HCG gives me terrible bacne I do not use it right now. Are we at risk for killing testicular cells with no regeneration in the future?
 
I have heard that not using HCG concurrently with TRT will cause shrikage of improtant testicular cells and death over time. Rendering the balls damaged. I have also heard that HCG is not necessary if one does not feel good on it. And we can regain fertility just by adding a fertility protocol like HCG, HMG, nolvadex, clomid, ect.

So, because HCG gives me terrible bacne I do not use it right now. Are we at risk for killing testicular cells with no regeneration in the future?
I’m not sure but there are several anechdotes of men successfully having children after using steroids For years with no hcg.
 
Here's my n=1 experience: For about 2.5 years I did not include HCG with my TRT and now that I have included it back in at 500iu every other day, my balls are still not as large as how they used to be.

Granted, this seems to be more of an aesthetic than a functional issue since many guys are still able to have children after long periods of no HCG and then jumping on fertility protocols.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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