Hi all,
I'm about to start enclomiphene (in 9 days) and I'm still trying to figure out if I should start anastrozole at the same time. I am confused because in various posts and studies there seems to be conflicting information about whether EN raises or lower E. In some studies it says it raises E but has anti-estrogenic effects... "Estrogen is known to potentiate secretion of hGH and IGF-1 levels. Enclomiphene citrate increases serum estradiol levels. We suspect that the anti-estrogen effects of enclomiphene citrate are working at either the hypothalamic-pituitary level or possibly on the liver to reduce IGF-1 levels. "
I know EN is referred to as an estrogen-antagonist but this study Nelson posted refers to it raising E levels.
Alexander W. Pastuszak*, Houston, TX; Ronald D. Wiehle, Gregory Fontenot, Joseph Podolski, The Woodlands, TX; Larry I. Lipshultz, Houston, TX
In the past I've used 2000IU HCG EOD for restart (had to stop trt for fertility) and .25mg of anastrozole Tuesday's and Friday's seemed to be the right amount for me to handle the raise in estrogen from the HCG.
When I was one TRT before I was taking 500IU HCG EOD and about 130mg of Test and again the .25mg of anastrozole 2x weekly seemed to be the right amount to handle any estrogen symptoms.
Can anyone share their experience about using anastrozole (how much) with enclomiphene? Or is it completley unnecessary?
Finally, I see studies with data on hormones fluctuations post EN therapy but only making passing reference (no numbers) to estrogen levels rising . Does anyone have the before and after numbers from EN therapy and is the EN only anti-estrogenic in certain tissue?
Thanks!
I'm about to start enclomiphene (in 9 days) and I'm still trying to figure out if I should start anastrozole at the same time. I am confused because in various posts and studies there seems to be conflicting information about whether EN raises or lower E. In some studies it says it raises E but has anti-estrogenic effects... "Estrogen is known to potentiate secretion of hGH and IGF-1 levels. Enclomiphene citrate increases serum estradiol levels. We suspect that the anti-estrogen effects of enclomiphene citrate are working at either the hypothalamic-pituitary level or possibly on the liver to reduce IGF-1 levels. "
I know EN is referred to as an estrogen-antagonist but this study Nelson posted refers to it raising E levels.
MP76-07
COMPARISON OF THE EFFECTS OF ORAL ENCLOMIPHENE CITRATE AND TOPICAL TESTOSTERONE GELS TREATMENT ON SERUM HORMONES, ERYTHROCYTOSIS, LIPIDS, AND PROSTATE SPECIFIC ANTIGENAlexander W. Pastuszak*, Houston, TX; Ronald D. Wiehle, Gregory Fontenot, Joseph Podolski, The Woodlands, TX; Larry I. Lipshultz, Houston, TX
In the past I've used 2000IU HCG EOD for restart (had to stop trt for fertility) and .25mg of anastrozole Tuesday's and Friday's seemed to be the right amount for me to handle the raise in estrogen from the HCG.
When I was one TRT before I was taking 500IU HCG EOD and about 130mg of Test and again the .25mg of anastrozole 2x weekly seemed to be the right amount to handle any estrogen symptoms.
Can anyone share their experience about using anastrozole (how much) with enclomiphene? Or is it completley unnecessary?
Finally, I see studies with data on hormones fluctuations post EN therapy but only making passing reference (no numbers) to estrogen levels rising . Does anyone have the before and after numbers from EN therapy and is the EN only anti-estrogenic in certain tissue?
Thanks!
