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Understanding Testosterone Replacement Therapy and Managing Side Effects

Jul 22

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13 min summary podcast: Introduction Hello everybody, Nelson Vergel here with ExcelMail.com. ExcelMail.com is a four-year-old forum, online site, with more than 14,000 members. Some of them are doctors, pharmacists, dietitians, exercise...

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How U.S. Blood Banks Handle Therapeutic Phlebotomy for Men on Testosterone Replacement Therapy (TRT)

Jul 15

How U.S. Blood Banks Handle Therapeutic Phlebotomy for Men on Testosterone Replacement Therapy (TRT) Blood centers have had to adapt their policies because the polycythemia/erythrocytosis that often accompanies TRT creates both medical need...

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Download TRT Clinical Guide from ExcelMale.com

Jul 15

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ExcelMale.com Quick Guide: DIAGNOSIS OF HYPOGONADISM: Symptoms and signs suggestive of testosterone deficiency in men: A. More specific symptoms and signs • Incomplete or delayed sexual development, eunuchoidism • Reduced sexual desire...

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U-Shaped Association Between Testosterone and Fractures

Jul 12

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The occurence of fractures in an elderly population is a significant concern, so this study looked at the relation between the number of fractures and hormone levels, including testosterone. It found fractures were higher at both low and high...

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Iron Supplementation Protocol to Raise Ferritin FAST While on TRT: The Vorck Protocol

Jul 12

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The Vorck Protocol Summary Background: The protocol was developed by a TRT user since 2001 who had difficulty recovering ferritin levels after blood donations. After conducting personal research and consulting with a hematologist in May 2021, he...

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Estrogen-It's what makes a real man

Jul 05

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Study: Low estrogen can cause problems for men Study: Low estrogen can cause problems for men (2013) Dr. Joel Finkelstein, an endocrinologist at Harvard Medical School and the lead author of a new study, talks about the effects of declining...

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Why Use hCG With TRT?- A Clinical Review

Jul 02

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Using hCG in Men on Testosterone Replacement Therapy (TRT) – A Clinical Review Introduction Exogenous testosterone replacement therapy (TRT) can profoundly suppress the hypothalamic-pituitary-gonadal (HPG) axis through negative feedback. By...

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The Evolution of Testosterone Products in the U.S. (1935-2025)

Jun 27

Thanks to Dr Sun for this diagram. Timeline details (left → right) YearProduct (image above/below the line)Form & delivery 1935-1937No product image—text block below the line: “Testosterone first synthesized” with a bullet list of early...

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Shifting the Testosterone Treatment Paradigm with Oral Testosterone (Kyzatrex)

Jun 26

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Again you heard it here first! Nelson's domain the one and only! Very informative webinar on the use of the newer oral TU formulations. Testosterone therapy has long been dominated by injectable and topical formulations, but the landscape...

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Elevated Hematocrit from Testosterone Therapy vs High-Altitude Adaptation: A Comparative Analysis

Jun 22

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From this thread: WARNING: Do not believe Internet "gurus" proclaiming no need to manage hematocrit on TRT - Excel Male TRT Forum Underlying Physiological Mechanisms Testosterone Replacement Therapy (TRT) and Erythrocytosis: Exogenous...

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The hormonal regulation of men’s sexual desire, arousal, and penile erection

Jun 21

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Briefing Document: Hormonal Regulation of Male Sexual Desire, Arousal, and Penile Erection Source Rastrelli, G., Antonio, L., Carrier, S., Isidori, A., & Maggi, M. (2025). The hormonal regulation of men’s sexual desire, arousal, and penile...

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What it the purpose of Sex Hormone Binding Globulin (SHBG) ?

Jun 17

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My question might be a basic one, but what is the purpose of Sex Hormone Binding Globulin (SHBG)? In general terms I appreciate that SHBG binds to Total Testosterone (along with Albumin) to give us Free Testosteron. My question is not about...

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