Testosterone

What is the Optimum TRT Dose for Muscle Growth? : Nelson Vergel Reviews the Data

Jan 18

Landmark Study Reveals How Different Testosterone Doses Affect Muscle, Fat, and Health Markers in Young Men A deep dive into one of the most influential studies on testosterone dosing reveals key takeaways for anyone interested in hormone...

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Older Men Metabolize Testosterone More Slowly Than Young Men

Jan 18

Why Older Men May Need Less Testosterone: The Surprising Science of Metabolic Clearance 1. Introduction: The Hormonal Paradox In the world of hormone replacement therapy and longevity, the prevailing assumption is often that "more is better." If...

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Sex Hormone Binding Globulin (SHBG): The Complete Guide for Men on TRT

Jan 02

By Nelson Vergel | ExcelMale.com | Updated December 2025 When evaluating testosterone levels, most men focus exclusively on total testosterone—a single number that tells only part of the story. What many don't realize is that a protein called...

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Subcutaneous Testosterone Injections: The Complete Guide for Men on TRT

Jan 02

Are you tired of painful intramuscular injections and wondering if there's a more comfortable way to administer your testosterone replacement therapy? For decades, intramuscular (IM) injections have been the standard method for testosterone...

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Oral Testosterone Therapy: A Complete Guide to Jatenzo, Tlando, Kyzatrex, and Emerging Options

Dec 29

By Nelson Vergel | ExcelMale.com | Updated December 2025 Summary: This comprehensive guide examines the development of FDA-approved oral testosterone products—Jatenzo, Tlando, and Kyzatrex—which overcome the liver toxicity problems of earlier...

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Sexual Function on TRT: Why Testosterone Alone May Not Be Enough for Erectile Function

Dec 29

Many men begin testosterone replacement therapy expecting their sexual function to improve across the board—better libido, stronger erections, enhanced satisfaction. And while TRT often delivers significant benefits for desire and overall sexual...

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Fewer than half of HIV+ men found to have low testosterone are treated with TRT

Dec 20

This nationwide study examines the prevalence of testosterone deficiency and the subsequent use of replacement therapy among men living with HIV. By analyzing data from over 100 million patients, researchers discovered that healthcare providers...

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US Federal and State Regulations on Testosterone and HCG

Dec 17

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Testosterone is a controlled substance in the US, specifically a Schedule-III controlled substance (in all but one State), and this includes any form of testosterone including injectable, transdermal, patches, pellets, and any compound or product...

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Key Historical Failures and Lessons Learned from Attempts to Get a Testosterone Product FDA-Approved for Women

Dec 12

FDA Approval of Testosterone Therapy for Women: An Analysis of Historical Failures, Regulatory Hurdles, and a Path Forward Executive Summary The landscape of testosterone therapy presents a stark gender disparity: while over 31 FDA-approved...

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HCG Use in Men on TRT or as Monotherapy: Over 200 Questions and Answers

Dec 05

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I collected questions and answers posted on ExcelMale.com in the last 10 years about the use of human chorionic gonadotropin in men who want to prevent loss of testicular size and fertility while on testosterone replacement therapy or that want...

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Upcoming FDA Expert Panel on Testosterone Replacement Therapy for Men

Dec 02

@Nelson Vergel We need you here! https://www.fda.gov/patients/fda-expert-panels/fda-expert-panel-testosterone-replacement-therapy-men-12102025 Location: FDA White Oak Campus, 10903 New Hampshire Ave., Building 31, Great Room, Silver...

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Practical Clinical Summary on Testosterone Therapy in Women

Nov 25

Practical Clinical Summary on Testosterone Therapy in Women (From ExcelMale.com) Based on the ExcelMale forum threads and related clinical literature, here's a comprehensive extraction of practical content for a clinical article: Physiological...

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