Nelson Vergel

Comparison of U.S. Clinical Guidelines on Hormone Replacement Therapy (HRT) in Women
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These are not usually what many US clinics follow, but I wanted to show what the guidelines say. Comparison of U.S. Clinical Guidelines on Hormone Replacement Therapy (HRT) in Women Multiple U.S. medical organizations—including The Menopause...
Can Certain Blood Pressure Medications Decrease Hematocrit?
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ARBs, or Angiotensin II Receptor Blockers, are a class of medications primarily used to treat high blood pressure (hypertension). They also play a role in managing heart failure and protecting kidney function, particularly in patients with...
How Compounding Pharmacies Are Challenging Big Pharma on Fair Access
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13-Minute Podcast: This podcast discussion examines the burgeoning role of compounding pharmacies, particularly in the context of GLP-1 medications, and how they are challenging the established dominance of Big Pharma. Driven by soaring drug...
Can Clomiphene / Enclomiphene Reverse Testicular Atrophy? Review of Limited Data.
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Below is a synthesis of what the literature presently shows about clomiphene (and its trans-isomer enclomiphene) and reversal of testicular atrophy in men. What hard data exist? Setting Study design (n) Testicular-volume result Time to...
Testosterone Therapy in Pre- and Post-Menopausal Women: Deep Dive
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Testosterone Therapy in Pre- and Post-Menopausal Women Testosterone Therapy for Women: Indications and Evidence (2010–2025) Low Sexual Desire (HSDD) and Sexual Function Evidence: Multiple randomized controlled studies (RCTs) and meta-analyses...
HCG plus TRT to Prevent / Reverse Testicular Shrinkage and Decreased Fertility
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Human Chorionic Gonadotropin (From the book Testosterone: A Mans Guide, amazon.com) Short podcast: hCG: What Every Man Should Know Good summary : Why Use hCG With TRT?- A Clinical Review Human chorionic gonadotropin (HCG) (not to be confused...
Why Use hCG With TRT?- A Clinical Review
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Using hCG in Men on Testosterone Replacement Therapy (TRT) – A Clinical Review Introduction Exogenous testosterone replacement therapy (TRT) can profoundly suppress the hypothalamic-pituitary-gonadal (HPG) axis through negative feedback. By...
The Evolution of Testosterone Products in the U.S. (1935-2025)
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Thanks to Dr Sun for this diagram. Timeline details (left → right) YearProduct (image above/below the line)Form & delivery 1935-1937No product image—text block below the line: “Testosterone first synthesized” with a bullet list of early...
Testosterone Replacement Therapy (TRT) Facts Every Man Should Know
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Testosterone Replacement Therapy (TRT) can be life-changing for many men suffering with low testosterone symptoms. However, there are crucial facts that most men are not told by their physicians before they start TRT. Here are the top facts that...
Smoking Cessation's Effects on Male Hormonal Levels
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This scientific paper investigates the effects of smoking cessation on hormonal levels in men, specifically focusing on steroid hormones like testosterone, DHEA, DHEAS, cortisol, and sex hormone-binding globulin (SHBG). The researchers aimed to...
Elevated Hematocrit from Testosterone Therapy vs High-Altitude Adaptation: A Comparative Analysis
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From this thread: WARNING: Do not believe Internet "gurus" proclaiming no need to manage hematocrit on TRT - Excel Male TRT Forum Underlying Physiological Mechanisms Testosterone Replacement Therapy (TRT) and Erythrocytosis: Exogenous...
Medications that Can Impair Muscle Mass and Strength Gains from Resistance Training
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Introduction Many common medications – both prescription and over-the-counter – can influence the muscle mass and strength gains achievable through resistance exercise. Some drugs impair or blunt muscle hypertrophy and strength development, while...
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