Testosterone and HDL

I am almost 80 and still on TRT. My HDL is great. But there is more to the story.

At age 52 I almost died from a heart blockage likely due to unusually low HDL. After an angioplasty, my doctor treated the low HDL very aggressively using mostly huge doses of niacin. HDL more than doubled, and LDL was cut in half.

At age 70 my doctor suggested TRT to treat my osteoporosis after fosimax did not work. She prescribed 105 mg/week, but I upped that to 175 mg/week for more muscle size and strength. TRT worked and bone density is now in normal range. Muscle size and definition improved significantly. HDL remains just as good as before.

So, it is possible to take high dose TRT and maintain good HDL. At least in my case.
What dose of niacin do u currently take?
 
I am almost 80 and still on TRT. My HDL is great. But there is more to the story.

At age 52 I almost died from a heart blockage likely due to unusually low HDL. After an angioplasty, my doctor treated the low HDL very aggressively using mostly huge doses of niacin. HDL more than doubled, and LDL was cut in half.

At age 70 my doctor suggested TRT to treat my osteoporosis after fosimax did not work. She prescribed 105 mg/week, but I upped that to 175 mg/week for more muscle size and strength. TRT worked and bone density is now in normal range. Muscle size and definition improved significantly. HDL remains just as good as before.

So, it is possible to take high dose TRT and maintain good HDL. At least in my case.
Just curious you didn’t mention hematocrit numbers how are they for you? I know mine are at high normal just at 100mg/wk if I try to add more it would definitely tip the scale for me
 
My HDL pre TRT was persistently in the 32-34 range. since starting TRT 10 years ago it has dropped to 28. I stopped the AI and it went back up to 34. I can not get it to go up no matter what I eat and I tried everything. And I can't take niacin as I had an allergic reaction. I am also on HCG and was wondering if that plays any roles in HDL or Trigs
 
Also, try NAC although you can no longer buy it on Amazon

 
How long ago did you stop the AI? Are you overweight ? What other supplements are you taking ? Do you know if your sensitive estradiol normalized ?
Sorry I just seen your question. I stopped the AI after the labs with a 28 about 2 months ago, so I am curious if it will rise now. I will retest in a couple weeks. I have also stopped HCG. My Trigs have been high since being on HCG.Yes a little overweight.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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