The HDL decrease happens in all TRT options but is dose-dependent. No HDL drop happens in doses equivalent to 100 - 150 mg per week of injectable testosterone.
Low HDL in combination with decreased
Lipoprotein A (along with increased hematocrit) can substantially increase cardiovascular risks in high dose T or anabolic steroid users.
Am J Cardiol. 1996 Jun 1;77(14):1244-7.
Testosterone decreases lipoprotein(a) in men.
Zmunda JM1, Thompson PD, Dickenson R, Bausserman LL.
Abstract
We administered testosterone, with or without the aromatase inhibitor testolactone, to determine the effects of testosterone and its aromatization to estradiol on Lp(a) levels in normal men. Average Lp (a) values decreased by 37% during testosterone alone and by 28% when testosterone and testolactone were combined, suggesting that testosterone reduces Lp(a) in men primarily by an androgenic effect and not by its conversion to estradiol.
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Lipoprotein (a) and cholesterol in bodybuilders using anabolic androgenic steroids
We examined the influence of self-administered anabolic androgenic steroids (AAS) on the lipogram of male bodybuilders. Serum lipoprotein (a) (Lp(a)), total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels were measured in 10 experimental and 8 control male competitive bodybuilders. The proportion of subjects with serum Lp(a) levels above 30 mg.dl-1 was significantly lower in the AAS group than the non-AAS group. HDL-C levels were significantly lower and LDL-C levels significantly higher in the AAS group than the non-AAS group. These data suggest that AAS in male bodybuilders have a beneficial effect on serum Lp(a) levels but reduce the HDL-C:LDL-C ratio.
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