Take Homes for Your Practice from Princeton 4: ED, CVD, and Sexual Function

madman · May 8, 2025

* PDE5 meds MAY reduce MI, Stroke & Mortality

Take Homes for Your Practice from Princeton 4: ED, CVD, and Sexual Function - Martin Miner, MD and Noel N. Kim, PhD

Members of the Princeton 4 Commitee

madman · May 8, 2025

Concluding Remarks

madman · May 8, 2025

Conclusions: PDE5 Inhibitors in Women

madman · May 8, 2025

Thread 'PDE5 inhibitors (Cialis, Viagra, etc) and cardiac health: Princeton IV consensus guidelines:'

Dec 27, 2023

Been waiting on this one.

Damn, that is deep!

Abstract

Background

In 1999, 1 year after the approval of the first oral phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction(ED), the first Princeton Consensus Conference was held to address the clinical management of men with ED who also had cardiovascular disease. These issues were readdressed in the second and third conferences. In the 13 years since the last Princeton Consensus Conference, the experience with PDE5 inhibitors is more robust, and recent new data have emerged regarding not only...

madman · May 8, 2025

Thread 'Recommendations for the Management of ED and Cardiovascular Disease'

Aug 11, 2024

The main lessons from the article are:

Independent Risk Marker: Erectile dysfunction (ED) should be considered an independent risk marker for coronary artery disease (CAD). It predates significant cardiac events, including myocardial infarctions and sudden cardiac deaths, often by several years. Thus, it can serve as an early indicator for potential cardiovascular issues.
Inclusion in Risk Calculators: The P4 panel advocates for the inclusion of ED as a risk-enhancing factor in cardiovascular risk assessment tools. Currently, only the QRISK calculator incorporates...

madman · Aug 15, 2025

Thread 'Erectile dysfunction: A vital sign for cardiovascular health'

Aug 15, 2025

* The P4 panel recommendations confirm that ED is a strong, independent predictor of cardiac events, even when traditional risk factors such as cholesterol, diabetes and blood pressure are controlled for. In short, ED is the body's "check engine light" for heart disease.

* Phosphodiesterase-5 (PDE5) inhibitors — such as sildenafil and tadalafil — remain first line therapy for ED. The P4 recommendations, however, suggest that these medications may offer more than symptom relief. Multiple large studies show that men taking PDE5 inhibitors have lower rates of heart...

madman · Aug 18, 2025

Thread 'Struggling with ED? Dr. Jeff Albaugh Breaks Down Causes, Treatments, and How to Take Back Control'

Aug 18, 2025

Great presentation!

I have been stressing this numerous times over the years.

ED is multifactorial and vascular issues are the most common cause.

Stop getting caught up on T, DHT, estradiol let alone the myth that one needs high FT/DHT!

T plays a small role.

What about testosterone?

* testosterone is a hormone that works all over the body and it has a small role with erections but it has a big role with libido or sex drive so it is important but the key essential components is blood flow and nervous conduction

* deep sleep is critical to...

madman · Oct 25, 2025

Thread 'Cardiovascular Pharmacotherapy & Male Sexual Function'

Oct 25, 2025

Prof. Dr. Mahmoud Tantawy

madman · Oct 26, 2025

Thread 'The interplay of health and heart health on sexual function: understanding the impact of CVD on sexual dysfunction in men'

Oct 26, 2025

* Erectile dysfunction is a marker of underlying cardiac disease, but many doctors are just not asking!

@Nelson Vergel

This is powerful!

6:00-6:15

* You need to lose about 75% of the lumen of the coronary artery before you get your first cardiac symptom but if you lose even a small amount of the very small penile artery you get sexual problems