SubQ vs IM and E2

^ A few things that come into mind

That study was most likely done in Europe since Test E was used. Have you seen European men ? The majority are skinny... and 5/8 length needles are not really short like 3/8 or 5/16. Def not IM but not also SubQ, I would say Shallow IM. Anyone else agrees with me ? 5/8 in my thighs is shallow IM. I can feel the needle going through my muscle.
 
Due to considerations of individual response to delivery methods and even injection technique, I know you're not going to get an answer, does it increase or not, you'll be required to go to SQ and test yourself at 4-6 weeks, then back to IM for 4-6 weeks and test and compare the results. In those 12 total weeks you'll have to maintain a strict regimen never deviating as you'll introduce a variable. Otherwise it's all academic and highly debatable.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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