State-of-the-Art Lecture: Updates on testosterone replacement therapy CUA 2025
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madman
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madman
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TRT & Cardiovascular Disease
TRAVERSE Summary
FDA Label Change
TRAVERSE Summary
FDA Label Change
madman
Super Moderator
Novel TRT Options
TRT Timeline
Canadian Market
TRT Timeline
Canadian Market
It's coming!
ir.lipocine.com
SALT LAKE CITY, June 9, 2025 /PRNewswire/ -- Lipocine Inc. (NASDAQ: LPCN), a biopharmaceutical company leveraging its proprietary technology platform to enable effective oral delivery of therapeutics, today announced...
Lipocine Announces Filing of New Drug Submission for TLANDO® in Canada
New Drug Submission filed by Lipocine's licensing partner Verity Pharma Over 700,000 total prescriptions written annually for testosterone replacement therapy (TRT) in Canada, representing large...
ir.lipocine.com
- New Drug Submission filed by Lipocine's licensing partner Verity Pharma
- Over 700,000 total prescriptions written annually for testosterone replacement therapy (TRT) in Canada, representing large commercial opportunity
SALT LAKE CITY, June 9, 2025 /PRNewswire/ -- Lipocine Inc. (NASDAQ: LPCN), a biopharmaceutical company leveraging its proprietary technology platform to enable effective oral delivery of therapeutics, today announced...
madman
Super Moderator
@Marcel
www.excelmale.com
We have always been far worse off than the US when it comes to the treatment of men for testosterone deficiency.
Although there has been some improvement in certain areas we are still lacking in many others.
*In 2013, a comprehensive Canada-wide needs assessment revealed that over 25% of Canadian physicians were uncomfortable with the diagnosis and treatment of TD and identified significant knowledge gaps related to patient management.4 To address...
THE DEA And ACCESS TO TRT TELEMEDICINE - Page 6 - Excel Male Health Forum
COMMENTS DUE DATE: MARCH 31. THE DEA WANTS TO LIMIT YOUR ACCESS TO TELEMEDICINE EXECUTIVE SUMMARY: The DEA has proposed new rules to update the Ryan Haight Act, which could negatively affect telemedicine prescribing of non-narcotic medications in Schedules III, IV, and V. These rules would...
www.excelmale.com
We have always been far worse off than the US when it comes to the treatment of men for testosterone deficiency.
Although there has been some improvement in certain areas we are still lacking in many others.
*In 2013, a comprehensive Canada-wide needs assessment revealed that over 25% of Canadian physicians were uncomfortable with the diagnosis and treatment of TD and identified significant knowledge gaps related to patient management.4 To address...
Speakers: Ryan Flannigan & Premal Patel
Objectives:- Discuss cardiovascular considerations with Low Testosterone & Treatment
- Review current evidence with Low Testosterone & Treatment in the context of Prostate Cancer
- Identify strategies to treat older patients presenting with Low Testosterone
- Identify strategies to treat young patients presenting with Low Testosterone
madman
Super Moderator
For all the GPs, endocrinologists, urologists and T-clinics it needs to be stressed to your patients that in Canada we use/rely upon the linear law-of-mass action Vermeulen (cFTV) for testing free testosterone as it replaced the known to be inaccurate direct immunoassays yet many are still not aware that the cFTV tends to overestimate free testosterone by 20-30%.
*In contrast we concluded that, although overestimating free T by 20–30%, the formula according to Vermeulen was independent of SHBG, total T, and albumin [221]. Taken into consideration the moderate bias level, but most importantly less influenced by the latter three variables, the Vermeulen formula, for the time being, still appears to be the most robust approximation and deserves our recommendation as a free T calculator for clinical use
journals.lww.com
INTRODUCTION
Clinical practice guidelines on the diagnosis of male hypogonadism focus on clinical signs and symptoms of androgen deficiency, as well as biochemical assessment of low circulating testosterone (T). However, there is a longstanding debate, as well as a persisting controversy concerning biochemical assessment of serum T and in particular the use (and misuse) of free T. Free T, as advocated by the free hormone hypothesis, represents...
Unfortunately we do not have easy access to the most accurate assay for testing free testosterone the gold standard Equilibrium Dialysis and even then as of now there is no standardized ED assay let alone harmonized reference range for free testosterone.
The CDC has been working hard behind the scenes over the years on developing a standardized FT assay (ED-LC/MS/MS) and harmonized reference range for free testosterone.
Similar to what was done for harmonized TT.
* Assays that are standardized are designed to provide accurate results, traceable to “true” value-assigned certified reference materials and gold-standard reference methods.
Soon enough we will have a CDC Hormone Standardization Program (CDC HoSt) Certified Free Testosterone Procedure and a harmonized reference range for free testosterone!
Just a matter of time as this has been a painstaking wait!
We need this!
*In contrast we concluded that, although overestimating free T by 20–30%, the formula according to Vermeulen was independent of SHBG, total T, and albumin [221]. Taken into consideration the moderate bias level, but most importantly less influenced by the latter three variables, the Vermeulen formula, for the time being, still appears to be the most robust approximation and deserves our recommendation as a free T calculator for clinical use
Use of calculated free testosterone in men: advantages and... : Current Opinion in Endocrinology, Diabetes and Obesity
hting its relevance in preventing misdiagnosis and overtreatment of male hypogonadism. Recent findings While there is consensus on measuring total T – comprising sex hormone-binding globulin (SHBG)-bound, albumin-bound, and free T – as a first step in diagnosing male hypogonadism, evidence...
journals.lww.com
INTRODUCTION
Clinical practice guidelines on the diagnosis of male hypogonadism focus on clinical signs and symptoms of androgen deficiency, as well as biochemical assessment of low circulating testosterone (T). However, there is a longstanding debate, as well as a persisting controversy concerning biochemical assessment of serum T and in particular the use (and misuse) of free T. Free T, as advocated by the free hormone hypothesis, represents...
Unfortunately we do not have easy access to the most accurate assay for testing free testosterone the gold standard Equilibrium Dialysis and even then as of now there is no standardized ED assay let alone harmonized reference range for free testosterone.
The CDC has been working hard behind the scenes over the years on developing a standardized FT assay (ED-LC/MS/MS) and harmonized reference range for free testosterone.
Similar to what was done for harmonized TT.
* Assays that are standardized are designed to provide accurate results, traceable to “true” value-assigned certified reference materials and gold-standard reference methods.
Soon enough we will have a CDC Hormone Standardization Program (CDC HoSt) Certified Free Testosterone Procedure and a harmonized reference range for free testosterone!
Just a matter of time as this has been a painstaking wait!
We need this!
As usual Nelson's house is where it's at!
event.on24.com
Testosterone imbalances affect men, women, and children differently. In males, testosterone deficiency (hypogonadism) can lead to low libido, fatigue, and muscle loss, while excess may contribute to aggression and cardiovascular risks. In females, testosterone excess (hyperandrogenism), often associated with polycystic ovary syndrome (PCOS) or adrenal disorders, can cause excess hair growth, weight gain, and menstrual irregularities. In children...
Importance of free testosterone measurement in assessing androgen disorders
Thursday, March 27, 2025 at 1:00 PM Eastern Daylight Time.
Testosterone imbalances affect men, women, and children differently. In males, testosterone deficiency (hypogonadism) can lead to low libido, fatigue, and muscle loss, while excess may contribute to aggression and cardiovascular risks. In females, testosterone excess (hyperandrogenism), often associated with polycystic ovary syndrome (PCOS) or adrenal disorders, can cause excess hair growth, weight gain, and menstrual irregularities. In children...
Nelson Vergel
Founder, ExcelMale.com
You are an urology info machine!
madman
Super Moderator
Hot off the press!
25th Annual Fall Scientific Meeting of SMSNA!
Grapevine, Texas!
Great presentation!
1:29:40-1:43:30
Conclusions
25th Annual Fall Scientific Meeting of SMSNA!
Grapevine, Texas!
Great presentation!
1:29:40-1:43:30
Conclusions
madman
Super Moderator
We will have access to to this very soon!
* Importer / Innomar Strategies Inc. Oakville, ON L6L 0C4
https://www.innomar-strategies.com/
https://pdf.hres.ca/dpd_pm/00082355.PDF
Marius Pharmaceuticals, Inc.
2301 Sugar Bush Rd #510
Raleigh, NC 27612
US
Date of Authorization:
2025-11-10
Importer / Innomar Strategies Inc. Oakville, ON L6L 0C4
* Importer / Innomar Strategies Inc. Oakville, ON L6L 0C4
https://www.innomar-strategies.com/
https://pdf.hres.ca/dpd_pm/00082355.PDF
Marius Pharmaceuticals, Inc.
2301 Sugar Bush Rd #510
Raleigh, NC 27612
US
Date of Authorization:
2025-11-10
Importer / Innomar Strategies Inc. Oakville, ON L6L 0C4
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