Starting TRT today...couple of questions

tattoobytony

New Member
So I’d like to get some opinions. Is it better to take one test shot a week or two? I was also prescribed an AI and was wondering when would be best to take it? The doc wants to me to do the Test (200 mg) once a week intramuscular, two times a week on the hcg (I’m going with crisler method on that one), and the AI (anastrozole 1mg) three times a week. Also, thoughts on sub-q vs intramuscular with the test? I appreciate everyone’s time as I’m super nervous about going on anything.

My labs
Total T is 225.6 mg/dL (264-916)
Free T is 6.7 pg/mL (8.7-25.1)
SHBG is 41 nmole/liter (16.5-55.9)
Estradiol is 41 of/mL (8-35)
 
This is a protocol waiting to plunge you into hormone hell. Why in the world did he prescribe 3mg of anastrozole a week??? If you were a woman, recovering from breast cancer, maybe. Even with elevated e2 prior to the initiation of therapy, that much anastrozole will send your estradiol levels to the sub-basement.

Your SHBG is higher, larger less frequent doses make sense, but I’d adopt a schedule that called for 100mg ever 3.5 days. One single dose of 200mg weekly...not confidence inspiring.
 
When considering some men are AI over-responders who only need a small fraction of 1mg anastrozole tablet (.125 1x2 per week), 3mg per week seems ill advised until we know how you respond to AI's. There are other ways to control estrogen, like adjusting your TRT protocol to include multiple injections per week, less the better is most cases.

We have some members here who inject T daily and never need an AI as part of their protocol. It's also useful in controlling hematocrit in some cases.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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