SHBG Dropping

Pringle

Active Member
Haven’t posted in a while, but I am working through a baffling deal. When I started TRT 4 years ago my SHBG was 46, it fell into the 30’s and stabilized there for a couple of years….I have been on same T dosage range for well over a year now of 120 mg week divided E3.5D.

My SHBG has fallen over the past year, despite my T dosage remaining in the same general MG per week range…..I went from 30’s now all the way down to 15 on last two tests. I even ran a second test to ensure accuracy. I am not feeling as well on this protocol now and the only factor that is changing is SHBG. Total T last labs 896, E2 43, SHBG 15, Free T 31.2. We checked prolactin and AC1…..both were within normal ranges…..any thoughts on another avenue to check for reasons it is dropping? Thinking of going back to daily injections as a result of the falling SHBG may get my mojo back?
 
Why 1/3? If you'd elaborate
Thanks

Sure. Based on his current labs and from what I have seen happen to numbers when dosing is moved from E3.5D to ED, I estimate\predict the following will result with the suggested reduced dose: TT 700-800, FT 25-30 (that's top of the range FT). Somewhat reduced E2. And that would be perfect.
 

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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