SHBG Dropping

Pringle

Active Member
Haven’t posted in a while, but I am working through a baffling deal. When I started TRT 4 years ago my SHBG was 46, it fell into the 30’s and stabilized there for a couple of years….I have been on same T dosage range for well over a year now of 120 mg week divided E3.5D.

My SHBG has fallen over the past year, despite my T dosage remaining in the same general MG per week range…..I went from 30’s now all the way down to 15 on last two tests. I even ran a second test to ensure accuracy. I am not feeling as well on this protocol now and the only factor that is changing is SHBG. Total T last labs 896, E2 43, SHBG 15, Free T 31.2. We checked prolactin and AC1…..both were within normal ranges…..any thoughts on another avenue to check for reasons it is dropping? Thinking of going back to daily injections as a result of the falling SHBG may get my mojo back?
 
Why 1/3? If you'd elaborate
Thanks

Sure. Based on his current labs and from what I have seen happen to numbers when dosing is moved from E3.5D to ED, I estimate\predict the following will result with the suggested reduced dose: TT 700-800, FT 25-30 (that's top of the range FT). Somewhat reduced E2. And that would be perfect.
 

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