Pregnenolone levels staying low despite supplementation -blood work incuded; Please Help

[hunterdon goose]

Hello everyone- according to recent blood work I have low pregnenolone levels despite taking the expensive brand of PURE Encapsulations off of amazon ($0.30+/per dose). After taking 60mg for about a month I went from undetectable to still low levels of pregnenolone . I also had my DHEA levels looked at during the same time period where I was supplementing with 100mg DHEA a day from comparably cheaper Natrol brand on amazon and my DHEA levels received a modest (but still far larger boost than the PURE brand) boost. Why are my blood levels for DHEA and pregnenolone still low despite taking moderate doses ? Is it the manufacturer lying about the contents of the supplement ? Or am I totally wrong and my expectations for the blood levels I should be getting from the doses too high ?

Any recommendations on brands for pregnenolone would be great and welcomed as according to my bloodwork I would need to be taking 250mg-1.5g a day to get my levels above 180ng/dl

Thank you in advance guys .

 

[Systemlord]

Are you on statins, or have any GI problems?

Pure Encapsulations is a reputable brand.

 

[hunterdon goose]

Are you on statins, or have any GI problems?

Pure Encapsulations is a reputable brand.

I don't have GI problems nor am I on statins.

 

[hunterdon goose]

Are you on statins, or have any GI problems?

Pure Encapsulations is a reputable brand.

Also if I need higher strength doses for my pregnenolone, any brands you'd recommend ? While I like PURE as a brand, they highest strength they make for their pregnenolone offering is just 30mg, and I might need somewhere according to my bloodwork a dose as high as 250mg to 1.5g a day. Thanks

 

[Nelson Vergel]

I took 100 mg per day, and it took me from undetectable (not using hCG) to 95 ng/dL. I think it need 150mg/day to have a level which is midrange. Also, keep in mind that the pregnenolone test has to be based on LC/MS, not based on immunoassay.

Pregnenolone Lab Test at Discounted Labs

Pregnenolone test

www.discountedlabs.com

I used this supplement:

pregnenolone supplement

Pregnenolone and Progesterone for Men: Pharmacokinetics and Studies

"Pregnenolone can be administered orally, subcutaneously, intravenously, intranasally, and topically/transdermally. Oral pregnenolone has high metabolism and low bioavailability.28 It is lipophilic and readily crosses the blood brain barrier. There is very limited data on the pharmacokinetics...

www.excelmale.com

 

[Wolverine]

I and others have found that immediate release pregnenolone, such as Pure (which is the brand that I have taken), will increase progesterone, and not pregnenolone. You need to take lipid matrix formulas, such as Nelson took, to raise pregnenolone levels. Funny though that lipid matrix (which I have also taken) will not increase progesterone. What you are targeting to raise will affect which type of pregnenolone you take.

 

[Mastodont]

I took 100 mg per day, and it took me from undetectable (not using hCG) to 95 ng/dL. I think it need 150mg/day to have a level which is midrange. Also, keep in mind that the pregnenolone test has to be based on LC/MS, not based on immunoassay.

Pregnenolone Lab Test at Discounted Labs

Pregnenolone test

www.discountedlabs.com

I used this supplement:

pregnenolone supplement

Pregnenolone and Progesterone for Men: Pharmacokinetics and Studies

"Pregnenolone can be administered orally, subcutaneously, intravenously, intranasally, and topically/transdermally. Oral pregnenolone has high metabolism and low bioavailability.28 It is lipophilic and readily crosses the blood brain barrier. There is very limited data on the pharmacokinetics...

www.excelmale.com

You stopped using pregnenolone right?