Low E2 but high SHBG?

lookingforhelp

New Member
Quick question guys,



I've read a lot regarding high E2 causing high SHBG but I seem to have low E2 and raised SHBG?

my e2 was 8 (22-30) and my SHBG sits around the 40-50 mark. I am 26 and lean. Also having issues with fluctuating prolactin levels. I read a study somewhere regarding prolactin lowering Shbg. Will have to find it.

Am I a rare case? Can anyone help?


Thanks!
 
Thanks for your quick reply coastwatcher. I haven't started TRT yet as I was waiting to complete a growth hormone stimulation test my endo had ordered for me to have. I have yet to receive the results as I only had it last week.

I am trying to really exhaust all possibilities before starting TRT but I am feeling worse and worse fast. Joint pain is terrible and I am in the beginning stage of developing arthritis in my hands... this is amongst all my other symptoms.

I have a lot of lab results but I am away from home currently and my computer with them saved on is there. When I get home I am going to upload them all to see what you all make of it.

I was just trying to understand SHBG by researching and I find a lot about E2 raising SHBG but nothing about other reasons for it being elevated.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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