Isolated Systolic Hypertension

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bloathog21

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Can isolated systolic hypertension be caused by high e2, water retention etc? I’m on Valsartan 320mg and amlodipine 5mg. AM BP 144/64, PM BP 153/60. It’s pretty frustrating that much medication isn’t bringing it down. I’m getting labs soon but wondering if anyone else has had low diastolic and high systolic. If it were water retention, increased volume, I would think both would be elevated.
 
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