Power of Whey Protein: Unveiling its Influence on Blood Pressure

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Supplementation with WP can significantly decrease SBP but does not have a significant effect on DBP. WP may be a viable option for individuals with hypertension, but factors such as supplementation form, intervention duration, and underlying conditions can influence its effects. More extensive studies with varying WP doses and longer interventions are required to validate these findings.




Key Takeaways:

• Systematic review and meta-analysis examined the effects of whey protein (WP) supplementation on blood pressure (BP) in adults
• Pooled analysis showed a significant reduction in systolic blood pressure (SBP) with whey protein supplementation
• No significant effect on diastolic blood pressure (DBP) was observed
• WP supplementation reduced DBP in specific conditions: a dose of >30 g/day, WP isolates powder intervention, sample sizes of 100, intervention duration of 10 weeks, and studies conducted in patients with hypertension and a BMI of 25-30 kg/m2
• Further large-scale studies are needed to determine the precise mechanism and optimal dosage of WP supplementation for BP benefits

 

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Table 1 General characteristics of the included studies.

 

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Table 2 Results of risk of bias assessment for randomized clinical trials included in the current meta-analysis.

 

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Table 3 GRADE approach summary of findings and quality of evidence assessment.

 

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Figure 2 Forest and funnel plot with weighted mean difference and 95% confidence intervals (CIs) for the effect of whey protein supplementation on systolic blood pressure (SBP).

 

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Table 4 Subgroup analyses for the effects of whey protein supplementation on blood pressure.

 

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Figure 3 Forest and funnel plot showing weighted mean difference and 95% confidence intervals (CIs) for the effect of whey protein supplementation on diastolic blood pressure (DBP).

 

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Figure 4 Nonlinear dose-response relationships between whey protein (a) duration of intervention (weeks), (b) dosage (g/d), and unstandardized mean difference in SBP. The 95% CI is shown in the shaded areas.

 

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Figure 5 Nonlinear dose-response relationships between whey protein (a) duration of intervention (weeks), (b) dose (g/day), and unstandardized mean difference in DBP. The 95% CI is shown in the shaded areas.

 

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Figure 6 Mechanism of action of whey protein on blood pressure.