Interesting Low e2 Fix

GreenMachineX

Well-Known Member
For those who don’t know my history, I have a consistent lowish estrogen problem because I can’t raise my testosterone dose high enough to aromatize enough e2, due to erythrocytosis. Using 60mg twice per week right now and that has my Hemoglobin at 17 and hematocrit at 50.9 so far. Going to retest in a few weeks to ensure it doesn’t climb any higher. This has my e2 sensitive at 17, and I still get low e2 symptoms at this level.

When I was running ecdysterone for 8 weeks, my sensitive e2 climbed to 37 and I felt great. This isn’t the thread for “ecdy doesn’t work! It was something else!”. For this threads sake, humor me that it was the cause. When I dropped it, symptoms have resumed. I’ve tried DHEA and it didn’t cut it. It gives me a whole different set of side effects.

My question is, is there anything wrong with never coming off, say, 400mg of cyclodextrin enclosed ecdysterone? My lab work looked great, other than my LDL being 120, but VLDL and triglycerides were great. CBC and chem/liver/electrolytes were great. Other interesting note, in the doctor office a few days ago, my BP was 138/82. This is 2 weeks off ecdy. While on ecdy, it was 117/72.

Anyone have any thoughts?
 
What low E symptoms are you coping with? You should run SHBG, by the numbers ~17 isn't low, presumably that's your trough and is the lowest point, most certainly it's up a bit.
We know that SHBG binds to E just like it does for Test. If your SHBG was let's say in the 60's like this other person, then conceivably those numbers could be low, for YOU because the E is bound up, less Free E to work in the body.
An additional test if it's affordable for you would be "Estradiol, Free", run that alongside the Sensitive E2.
 
What low E symptoms are you coping with? You should run SHBG, by the numbers ~17 isn't low, presumably that's your trough and is the lowest point, most certainly it's up a bit.
We know that SHBG binds to E just like it does for Test. If your SHBG was let's say in the 60's like this other person, then conceivably those numbers could be low, for YOU because the E is bound up, less Free E to work in the body.
An additional test if it's affordable for you would be "Estradiol, Free", run that alongside the Sensitive E2.
I get achy, mild anxiety, reduced gym pumps, reduced libido, etc.
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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