How long did it take you to notice any effects from TRT?

[Arcagrepeats9]

TRT help


In short: Today is my second day on testosterone gel (50 mg). I know gel isn’t the best option. I don’t feel any difference mood-wise or libido-wise yet. I know some people say it can take 3 weeks or more to notice the effects of testosterone. The problem is, there’s a detail from a study that contradicts the notion that the effects of trt takes several weeks. Study showed that exogenous testosterone rapidly (within 1 hour) increased aggression in dominant and impulsive men. https://jual.nipissingu.ca/wp-content/uploads/sites/32/2014/10/biological-psychiatry.pdfSo what should I expect to be true? I hope there’s plenty of time to expect changes. How long did it take you to notice any effects from TRT? How long did the changes take to plateau?

Edit: I’m not looking for any aggression-increasing effects from trt. I’m only referring to it because if testosterone can have any effects in such a short amount of time, it would make most logical sense to think that many people can feel any of it’s effects in a short amount of time, which I hope isn’t the case, because I haven’t felt anything yet. I hope there’s plenty of time for significant changes to take place. The more time, the better.


Here‘s my testosterone blood test results from before I started on gel:

1: Total Testosterone: 10.07 nmol/l (first measurement). Free Testosterone: 0.2113 nmol/l (first measurement). SHBG: 29 nmol/l (first measurement).

2: Total Testosterone: 10.04 nmol/l (second measurement). Free Testosterone: 0.2088 nmol/l (second measurement). SHBG: 30 nmol/l (second measurement).

Reference ranges for Total, Free Testosterone and SHBG was:

TT - 11.6-33.8 nmol/l

SHBG - 13-52 nmol/l

Calculated Free Testosterone - 0.1-0.7 nmol/l.

 

[Systemlord]

The problem is, there’s a detail from a study that contradicts the notion that the effects of trt takes several weeks. Study showed that exogenous testosterone rapidly (within 1 hour) increased aggression in dominant and impulsive men.

Some men are wired differently than others, some men are passive, and some men are not, therefore androgens affects everyone differently. It all depends what traits you’re born with.

How long did it take you to notice any effects from TRT? How long did the changes take to plateau?

On fast acting oral testosterone, Jatenzo (6 hour half-life/2 hour peak time) the first dose I felt significantly better coming from a 91 ng/dL baseline level. The lower your hormone level at pre-treatment, the more noticeable the benefits.

On testosterone gel, I did feel something on my first dose, insane energy levels for several hours, but absorption became a problem as time went on.

Men have different types of androgen receptors, sensitivities at the receptors, receptor density differences, as well as the abilities for tissues to respond. Heavy metal toxicity and inflamed bi lipid membrane will prevent or make it more difficult for testosterone from reaching the androgen receptors.

Your mileage may very considerably.

We are NOT all created equal like our parents tell us!

Your current medical problems could be hindering your response to therapy, at least initially.

Onset of effects of testosterone treatment and time span until maximum effects are achieved

Results​

Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, with no further increments expected beyond. Changes in erections/ejaculations may require up to 6 months. Effects on quality of life manifest within 3–4 weeks, but maximum benefits take longer. Effects on depressive mood become detectable after 3–6 weeks with a maximum after 18–30 weeks. Effects on erythropoiesis are evident at 3 months, peaking at 9–12 months. Prostate-specific antigen and volume rise, marginally, plateauing at 12 months; further increase should be related to aging rather than therapy. Effects on lipids appear after 4 weeks, maximal after 6–12 months. Insulin sensitivity may improve within few days, but effects on glycemic control become evident only after 3–12 months. Changes in fat mass, lean body mass, and muscle strength occur within 12–16 weeks, stabilize at 6–12 months, but can marginally continue over years. Effects on inflammation occur within 3–12 weeks. Effects on bone are detectable already after 6 months while continuing at least for 3 years.

Conclusion​

The time-course of the spectrum of effects of testosterone shows considerable variation, probably related to pharmacodynamics of the testosterone preparation. Genomic and non-genomic effects, androgen receptor polymorphism and intracellular steroid metabolism further contribute to such diversity.

 

[Seagal]

What are your symptoms?
What @Systemlord said: The lower your hormone level at pre-treatment, the more noticeable the benefits.
I felt symptom improvement (fatigue, lethargy, anhedonia) with androgel within one day.