High SHBG, low free T. TRT?

I've also seen very similar numbers between the Direct and Equilibrium Dialysis methods, despite everyone saying the Direct method is garbage
Almost, if you pretend the units of the direct RIA method are wrong or multiply the direct number by 10 as had been discussed. In reality the conversion factor more like 6-7. More info here.

 
In my personal experience, the TruT calculator is completely off. I've posted the numbers somewhere and it wasn't even close. I've also seen very similar numbers between the Direct and Equilibrium Dialysis methods, despite everyone saying the Direct method is garbage
What do you mean by "Direct"? Do you mean from using total T, SHBG, and albumin with Vermeulen formula? Or do you mean RIA?

RIA is another world, maybe it has some meaning, but would need a conversion.
 
That's how it works. When I was diagnosed with low-T, my Total T was 91 ng/dL (3.2 nmol/L) and Free T below range, SHBG 11.
Actually, it is maybe better to have a total T that low to have the right diagnostic. Here, in Europe, if the total T is above 400 ng/dL the MD will skip all other tests and say that it is fine.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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