HCG & Gynecomastia

Johnny Test

Active Member
QQ. If one’s E2 levels were within range is it safe to say you probably won’t get gyno while on TRT & HCG? Or is it when the HCG pushes your E2 above the normal threshold that you’re prone to getting gyno? And I’m mostly referring to pseudogynocastemia not the lump kind behind the nipple. Thanks in advance.
 
Gynecomastia occurs if you have genetic predisposition in the presence of low T, high estradiol and high IGF-1.
Are you using hCG alone? What dose and frequency? Did you have gyno as a teenager?



 
Had gyno as a teen. Low test as a mid 20 year old. In the high 300s. Stopped using HCG because of acne, sweating, greasiness. Maybe exacerbated gyno a little with HCG and Test.
 
This one claims to be good
Oh wow I worked plumbing one year and we had a job at his office. He was a stickler! like almost mind numbing. However, I did hear he is very successful in what he does. Thanks Nelson.
 
Gynecomastia occurs if you have genetic predisposition in the presence of low T, high estradiol and high IGF-1.
Are you using hCG alone? What dose and frequency? Did you have gyno as a teenager?



I’m using HCG 400iu twice a week. I’m on 120mg of Test split 60/60 (M & TH) I take the HCG the day before. Never had gyno as a kid, my test level is 633 when I had bloodwork taken in the trough. Three hours before my next injection. E2 sits at 34 with no AI.
 
I’ll side with it seemingly being more of a genetic thing. I’ve had my E2 all over the place and around 80 for like a year and have been fat before and I’ve never gotten gyno. I know other guys that aren’t even on TRT that got gyno.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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