Gene's Nitric Oxide Stack

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)

Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)

More Than a Muscle Pump: The Surprising Science of the Nitric Oxide Stack​

In the biohacking world, we often chase complex peptides or experimental compounds, but we frequently overlook the most fundamental currency of life: blood flow. In the quest for longevity, systemic vascular efficiency is the baseline upon which all other health markers are built. As we age, our ability to maintain vasodilatory capacity diminishes, impacting everything from cognitive sharpness to metabolic health. "Gene’s Nitric Oxide Stack," a protocol born and refined within the ExcelMale community, has emerged as a definitive solution for men seeking to optimize this system. This isn't just a gym supplement routine; it is a sophisticated approach to anti-aging that leverages amino acids and targeted pharmaceutical interventions to restore the body’s most vital delivery mechanism.

Beyond the Mirror: The Science of the Sustained Pump​

For the average gym-goer, the "pump" is a transient aesthetic goal—a fleeting moment of muscle fullness. However, for a longevity specialist, a "harder pump" and increased vascularity are indicators of high-functioning endothelial health. The Nitric Oxide Stack is engineered to produce a state of vasodilation that doesn't simply vanish when you rack the weights.

By optimizing the nitric oxide signaling pathway, this protocol facilitates a sustained pump that carries through your daily life. This is a critical distinction: the visual vascularity is a proxy for your body’s ability to keep its "pipes" open. When you maintain that fullness hours after a workout, you are essentially providing proof of concept that your circulatory system is operating at peak efficiency, ensuring constant nutrient delivery to peripheral tissues.

The Foundation of Performance: Hard Science for Sexual Vitality​

One of the most immediate benefits of systemic vasodilation is the restoration of sexual function. From a clinical perspective, erection quality is often the "canary in the coal mine" for cardiovascular health. Because the Nitric Oxide Stack focuses on the root physiological requirements of performance—blood flow and retention—it provides a robust alternative to temporary fixes.

A Serious Solution for Erection Quality and Duration

This stack addresses both the quality and the duration of erections with clinical precision. For men navigating the aging process, this is not a matter of vanity, but of maintaining vital physiological function. By ensuring the vascular system can respond effectively to neurological signals, the protocol allows for a level of performance that many mistakenly believe is lost to time.

The Ultimate Nootropic: Future-Proofing the Neocortex​

Perhaps the most compelling argument for nitric oxide optimization is the "bodybuilder to brain health" pipeline. While most men start this stack for its physical benefits, they are unknowingly deploying a powerful shield against age-related cognitive decline. As we age, the micro-vasculature within the brain tends to narrow and tighten, a process that starves the brain of oxygen and is a primary driver of age-related dementia.

The stack acts as a nootropic by ensuring that the brain's smallest vessels remain dilated and resilient. This ensures that the neocortex and other critical regions receive a constant supply of the nutrients required for cognitive longevity. As the source material highlights:

"by increasing nitric oxide and getting that vascular dilation we're getting oxygen blood and nutrients in the areas of the brain that can provide us with a great anti-aging benefit in terms of neurological health."

The irony is profound: a protocol often associated with the bicep curl may actually be one of your most effective tools for protecting your mind.

Systemic Management: Blood Pressure and Prostate Function​

The benefits of the stack extend into the deeper mechanics of men’s health, specifically regarding the relaxation of smooth muscle tissue. This is particularly relevant for Benign Prostate Hyperplasia (BPH) and blood pressure management. Nitric oxide serves as a signal for these tissues to relax, directly easing the "inability to ease the problems" that typically characterize age-related prostate issues.

The secondary physiological advantages of this systemic relaxation include:

• Vascular Tension Reduction: Significant support for maintaining healthy blood pressure levels by reducing resistance within the arterial walls.
• Prostate Relief: Improvement in quality of life by relaxing the prostatic smooth muscle, easing the mechanical symptoms of BPH.
• Reduced Cardiac Load: By improving systemic flow, the heart is not required to pump against the same level of resistance, preserving cardiovascular longevity.

The Future of Your Vascular Health​

"Gene’s Nitric Oxide Stack" is far from a theoretical exercise; it is a "living protocol" backed by years of community peer-review within the ExcelMale community. The "enormously long" and widely viewed thread on ExcelMale.com serves as a testament to the real-world efficacy of this stack, offering a repository of shared experiences and optimization strategies.

This multi-front approach to anti-aging represents the best of biohacking: using fundamental biological pathways to solve complex aging problems. By focusing on the delivery system itself, we can protect our brains, our hearts, and our vitality simultaneously.

If blood flow is the delivery system for every nutrient your body needs, what happens to your longevity when you finally optimize that system?


More on Nitric Oxide in Men:

Nitric Oxide Pages

 

I have several questions. Is there really a point to taking arginine and horny goat weed at bedtime given that they would be largely processed out of one's system by morning? Also, I am currently taking 5mg cialis per day for BPH. The doctor increased the dose to 10mg for both BPH and ED, but I am concerned about the possible side effect of eye damage and vision loss. Do you have any concerns about that? And last, is there a brand of Horny Goat Weed that I can be sure contains what is supposed to contain? I tried Nature's Bounty brand, 150mg per day but felt absolutely no effect.

 

Have ordered everything Gene recommended. Cannot wait to see how much it improves my pump.

 

I split the 10mg Cialis in half, take 5mg before bed and 5mg in the morning—no side effects.

 

I have been on various types of NO supplementation for years, then I came across this forum. I worked well for me but from the beginning it was the larger number of pills that had to be taken that was somewhat an issue for me.

OK, I have been off of any type of NO supplementation for a while and I have restarted. The difference is that I used a powder form of Citrulline and had good results. Unable to find this product off hand I chose a pill form from Irwin Naturals. Not getting the same results so I am on the hunt for the powder.

The point I am making is that I have experienced a marked improvement in urine flow. The sudden urgency signals, sporadic "slow" to "moderate" flow patterns are gone. I seem to be hitting the urinal like a regular guy when the call comes in and while I am not peeing away like a racehorse, the flow is very acceptable and consistent.

With the NO attributes of relaxation of muscle tissue and vasodilation, I cannot help but possibly attribute my newfound expereince as being somewhat connected.

Any of y'all out there have any similar experiences?

 

I have been on various types of NO supplementation for years, then I came across this forum. I worked well for me but from the beginning it was the larger number of pills that had to be taken that was somewhat an issue for me.

OK, I have been off of any type of NO supplementation for a while and I have restarted. The difference is that I used a powder form of Citrulline and had good results. Unable to find this product off hand I chose a pill form from Irwin Naturals. Not getting the same results so I am on the hunt for the powder.

The point I am making is that I have experienced a marked improvement in urine flow. The sudden urgency signals, sporadic "slow" to "moderate" flow patterns are gone. I seem to be hitting the urinal like a regular guy when the call comes in and while I am not peeing away like a racehorse, the flow is very acceptable and consistent.

With the NO attributes of relaxation of muscle tissue and vasodilation, I cannot help but possibly attribute my newfound expereince as being somewhat connected.

Any of y'all out there have any similar experiences?

Being 70 years old and dealing with BPH I cannot say that the stack has improved my urinary issues at all.

Take a look at bulksupplements.com for your L-Citrulline powder. That's where I get my bulk supplements and I have been happy with their products for the most part . I would give them a 7 out of 10 score but that's just my experience.

I hope this helps.

 

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)



Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)

More on Nitric Oxide in Men:

Nitric Oxide Pages

I am using all of stack but only 1 time per day..... happy! but will up it to your recommendation and see results.... many thanks for recommendation.

 

It seems that Doxasozin has been on a shortage like ADC and Safemeds4all. Studies have been shared here about Tamsulosin HCl being a safe alpha blocker to use with Tadalafil, is there a reason why it's not mentioned as much? Shouldn't Tamsulosin (Flomax) work just fine as an alpha blocker with this stack?

I stopped using Flomax because it reduced the volume of my ejaculate.

 

Has anyone had low bp or even high bp while taking these supps 3x per day? If so did u just reduce the amounts or do it 2x instead of 3x perday?

 

Has anyone had low bp or even high bp while taking these supps 3x per day? If so did u just reduce the amounts or do it 2x instead of 3x perday?

My BP does come down some with supplements.
Can you post your numbers?

 

I stopped using Flomax because it reduced the volume of my ejaculate.

Did you switch to doxazosin? or just no alpha blocker?

 

What about arginine activating latent viruses that over 90% of all humans have?…

 

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)



Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)

More on Nitric Oxide in Men:

Nitric Oxide Pages

Hi Gene does this stack help men with low testosterone at 30 years old? Thanks

 

Did you switch to doxazosin? or just no alpha blocker?

So far, no other alpha blocker, but I'll ask my doc about it at next visit. I have kind of a guilty confession combined with an observation. I'm a poor sleeper and have been trying THC gummies lately . I've been using 15 mg before bed each night. I now sleep great and get up only once during the night to pee, as opposed to 4 or 5 times. Also, the force and volume of my stream is just amazing. It's like I'm in my 20s again.

 

Has anyone tried a variation of this where it's taken just 1x daily?

I ask because this would be cheaper to do if I use powders and I take some other powdered supps in the morning. If I really need to dose 3x day then capsules are going to be more convenient.

 

I know of at least 6 of the top man's health clinicians nationally who prescribe low dose daily tadalafil and doxazosin when a PDE5i as a mono therapy ED drug by it self doesn't work and the men have seen spectacular results.

And PubMed studies are fine to prove your point...but just know that you can usually find studies on PubMed that will counter such studies.

"The results indicated that combined therapy with sildenafil and doxazosin GITS for the treatment of ED and BPH/LUTS is safe and effective compared to sildenafil monotherapy".

An open, comparative, multicentre clinical study of combined oral therapy with sildenafil and doxazosin GITS for treating Chinese patients with erectile dysfunction and lower urinary tract symptoms secondary to benign prostatic hyperplasia - PubMed

Silendafil and others are vascular dilators? So are we masking maybe arterial narrowing or heart disease maybe it’s a sign to eat healthier and open em up with a better diet and understanding of why they narrow. Don’t get me wrong I only read a lot and try to do the right thing I take silendafil occasionally also I’m just interested in what others think?

 

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)



Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)

More on Nitric Oxide in Men:

Nitric Oxide Pages

 

If you have herpes 1 or 2 the arginine will cause a breakout.

 

Have ordered everything Gene recommended. Cannot wait to see how much it improves my pump.

I did not see a noticeable improvement in blood pressure, erections, or vascularity from Gene's stack. Since I was already taking 7.2 grams L-Citrulline daily, perhaps there was no room for improvement. Unfortunately Gene's stack produced a fair amount of gas and somewhat loose stools.

 

I know of at least 6 of the top man's health clinicians nationally who prescribe low dose daily tadalafil and doxazosin when a PDE5i as a mono therapy ED drug by it self doesn't work and the men have seen spectacular results.

And PubMed studies are fine to prove your point...but just know that you can usually find studies on PubMed that will counter such studies.

"The results indicated that combined therapy with sildenafil and doxazosin GITS for the treatment of ED and BPH/LUTS is safe and effective compared to sildenafil monotherapy".

An open, comparative, multicentre clinical study of combined oral therapy with sildenafil and doxazosin GITS for treating Chinese patients with erectile dysfunction and lower urinary tract symptoms secondary to benign prostatic hyperplasia - PubMed

In my case, having more severe post radiation prostate cancer therapy related ED, and having hypertension from hematocrit and hemoglobin at or above the high normal limits, (yes its being addressed and responding well) adding in Terazosin 2 mg bid, in addition to taking 10 mg of Tadalafil daily, made a huge difference. In all fairness, I did have shockwave treatments too, but I do think the big difference came from adding in the Terazosin. However, it is a very potent drug for lowering BP and will drop your pressure so be very careful. I had earlier tried L arginine at 3G day, with no benefit seen. I might try this again at the higher dose. But, my bottom line, ED improved dramatically to the point where before I could not obtain a useful erection with injecting Tri Mix. Now, I can achieve a useful erection simply by watching something sexual stimulating, porn, a beautiful woman walk down the street, fantasies of past girlfriends, you name it. This class of drugs combined with PDE 5 inhibititors are a great combination and the NO support is a really good add on.

 

I stopped using Flomax because it reduced the volume of my ejaculate.

Did you switch to a different prescription or stop altogether and how is that affected peeing at night?